While the majority of cochlear implant recipients benefit from device, it remains difficult to estimate degree for a specific patient prior implantation. Using data 2,735 cochlear-implant across three clinics, largest retrospective study outcomes date, we investigate association between 21 preoperative factors and speech recognition approximately one year after implantation explore consistency their effects constituent datasets. We provide evidence 17 statistically significant associations,...

Objective: Speech tests aim to estimate discrimination loss or speech recognition threshold (SRT). This paper investigates the potential SRTs from clinical data that target at characterizing loss. Knowledge about relationship between test outcome variables--conceptually linked via psychometric function--is important towards integration of different databases. Design: Depending on available data, SRT estimation procedures were compared and evaluated. A novel, model-based procedure was...

In contrast to the single sensory surface present in teleost fishes, several spatially segregated subsystems with distinct molecular and functional characteristics define mammalian olfactory system. However, evolutionary steps of that transition remain unknown. Here we analyzed system an early diverging tetrapod, amphibian Xenopus laevis, report for first time existence two odor-processing streams, sharply main bulb partially epithelium pre-metamorphic larvae. A lateral stream is formed by...

While cochlear implants have helped hundreds of thousands individuals, it remains difficult to predict the extent which an individual's hearing will benefit from implantation. Several publications indicate that machine learning may improve predictive accuracy implant outcomes compared classical statistical methods. However, existing studies are limited in terms model validation and evaluating factors like sample size on performance. We conduct a thorough examination approaches word...

The aim of this study was to investigate the efficacy a direct acoustic cochlear implant (DACI) for speech understanding in noise patients suffering from severe profound mixed hearing loss (MHL) due various etiologies compared preoperative best-aided condition. performed at five tertiary referral centers Europe (Belgium, Germany, Poland and Spain). Nineteen adult subjects with MHL (advanced) otosclerosis, ear canal fibrosis, chronic otitis media, tympanosclerosis or previous cholesteatoma...

Temperature perception has long been classified as a somesthetic function solely. However, in recent years several studies brought evidence that temperature also takes place the olfactory system of rodents. described an effective stimulus for sensory neurons Grueneberg ganglion located at entrance nose. Here, we investigate whether neuronal trace stimulation can be observed glomeruli and mitral cells bulb, using calcium imaging fast line-scanning microscopy. We show Xenopus tadpole...

To investigate the intracochlear position of latest Cochlear Nucleus 532 electrode array compared with straight 522 and precurved 512 arrays determine effect electrode-modiolus distance on electrically evoked compound action potential, C-levels, stapedius reflex thresholds (ESRTs), impedances.Postoperative high-resolution cone beam computational tomography images 30 patients 532, 522, implants were evaluated using Comet (Cochlea Measurement Tool) program to between 22 individual contacts...

The new implantable hearing system Codacs™ was designed to close the treatment gap between active middle ear implants and cochlear in cases of severe-to-profound mixed loss. actuator is attached conventional stapes prosthesis during implantation thereby provides acoustical stimulation through a stapedotomy cochlea. Cochlear (CIs) on other hand are an established option for profoundly deaf patients including losses that possible candidates Codacs™. In this retrospective study, we compared...

The encoding of odors by spatiotemporal patterns mitral/tufted (M/T) cells in the vertebrate olfactory bulb has been discussed controversially. Motivated temporal constraints from behavioral studies, we investigated information contained odor-evoked first-spike latencies. Using simultaneous recordings dozens M/T with a high resolution and quantitative ensemble correlation techniques, show that latency patterns, particular rank are highly odor specific reproducible. They reliably predict...

Objective The implantation of biohybrid electrodes was introduced a few years ago in our clinic. These coated with autologous mononuclear cells releasing anti-inflammatory and neuroprotective factors are thought to reduce insertion trauma maintain the vitality surviving spiral ganglion neurons. clinical feasibility this approach has already been demonstrated. In present retrospective study, four-year results two sides (classical electrode electrode) bilaterally implanted patients were...

<b><i>Background:</i></b> The conventional therapy for severe mixed hearing loss is middle ear surgery combined with a power aid. However, substantial group of patients cannot be treated adequately today’s state-of-the-art (SOTA) aids, as predicted by the accompanying part I this publication, where we compared available maximum output (MPO) and gain from technical specifications to requirements optimum benefit using common fitting rule. Here, intended validate...

Auditory masking occurs when one sound is perceptually altered by the presence of another sound. in frequency domain known as simultaneous and time temporal or non-simultaneous masking. This works presents a coding strategy that incorporates model to select most relevant channels for stimulation cochlear implant (CI). A previous version strategy, termed psychoacoustic advanced combination encoder (PACE), only used same purpose, this reason new has been temporal-PACE (TPACE). We hypothesized...

It was hypothesized that cochlear implant (CI) subjects would be able to correctly identify 1, 2, and 3 simultaneous pitches through direct electrical stimulation. We further the location on array fundamental frequency of have an impact performance."They gave me back speech but not music" is a sentence commonly heard by CI subjects. One reasons in music, multiple streams are frequently played at same time, which essential feature harmony. Current processors do allow users perceive such...

Objective: The objective of this study was to test if stimulating multiple electrodes can improve temporal pitch ranking performance at low and high stimulation rates. Design: Temporal cues are usually based on modifying the rate implant thereby provide a continuum pitches single electrode up approximately 300 Hz. Study sample: Ten cochlear subjects were asked rank stimuli presented with direct electrical stimulation. pulses applied one, three, six, or eleven electrodes. In one conditions...

Many olfactory receptor neurons use a cAMP-dependent transduction mechanism to transduce odorants into depolarizations. This signaling cascade is characterized by sequence of two currents: cation current through cyclic nucleotide-gated channels followed chloride calcium-activated channels. To date, it not possible interfere with these generator under physiological conditions potent and specific blockers. In this study we identified the styryl dye FM1-43 as blocker native Furthermore,...

Automatic gain control (AGC) compresses the wide dynamic range of sounds to narrow hearing-impaired listeners. Setting AGC parameters (time constants and knee points) is an important part fitting hearing devices. These do not only influence overall loudness elicited by devices but can also affect recognition speech in noise. We investigated whether matching points time between cochlear implant aid bimodal listeners would improve recruited 18 provided them all with same cochlear-implant...

Research suggests that cochlear implant (CI) use in elderly people improves speech perception and health-related quality of life (HRQOL). CI provision could also prevent dementia other comorbidities support healthy aging. The aim this study was (1) to prospectively investigate potential changes HRQOL (2) identify clinical action points improve treatment. Participants (n = 45) were recipients aged 60-90 with postlingual deafness. They divided into groups, according age: Group 1 20) received a...

Cochlear implantation has been a routine hearing rehabilitation procedure for years. Nevertheless, not all parameters that influence speech understanding after are known. We test the hypothesis whether there is connection between and position of different electrode types in relation to modiolus cochlea with identical processors. For this purpose, retrospective study, we compare results ("Straight Research Array" [SRA], "Modiolar [MRA] "Contour Advance" [CA]) from manufacturer matched pair...

Anatomical malformations, obliterations of the cochlea, or re-implantations pose particular challenges in cochlear implantation. Treatment methods rely on radiological and intraoperative findings include incomplete insertion, implantation a double array, radical cochleostomy. In addition, stiff electrode e.g., IE (IES) custom-made device (CMD, MED-EL), was prescribed individually for those special cases pre-inserted prior to facilitate challenging cases. Data outcomes after obliterated...

Objective: The objectives of the investigation were to evaluate effect a sound processor upgrade on speech reception threshold in noise and collect long-term safety efficacy data after 2½ 5 years device use direct acoustic cochlear implant (DACI) recipients. Study Design: study was designed as mono-centric, prospective clinical trial. Setting: Tertiary referral center. Patients: Fifteen patients implanted with implant. Intervention: Upgrade newer generation processor. Main Outcome Measures:...