A5037231355- Radical Photochemical Reactions
- CO2 Reduction Techniques and Catalysts
- Catalytic C–H Functionalization Methods
- HIV Research and Treatment
- Electrochemical Analysis and Applications
- HIV/AIDS drug development and treatment
- SARS-CoV-2 and COVID-19 Research
- Chemical Synthesis and Analysis
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
Shionogi (Japan)
2022-2025
Torrey Pines Institute For Molecular Studies
2023
Scripps (United States)
2023
Scripps Institution of Oceanography
2023
Scripps Research Institute
2023
Futaba (Japan)
2022
A mild, scalable (kg) metal-free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access valuable from simple acid feedstocks. This robust method relies on alternating polarity maintain the quality electrode surface local pH, providing a deeper understanding Hofer-Moest process with unprecedented chemoselectivity.
<title>Abstract</title> Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a threat to public health and the economy. Although several SARS-CoV-2 vaccines exist, they have failed elicit effective neutralizing antibody responses against emerging variants harboring spike protein mutations. Moreover, while certain neutralizing-antibody-based therapies were in early stages of pandemic, their performance declined with emergence Thus, it is...
Human immunodeficiency virus type-1 (HIV-1) protease is essential for viral propagation, and its inhibitors are key anti-HIV-1 drug candidates. In this study, we discovered a novel HIV-1 inhibitor (compound 16) with potent antiviral activity oral bioavailability using structure-based design approach via X-ray crystal structure analysis improved metabolic stability, starting from hit macrocyclic peptides identified by mRNA display against protease. We found that the improvement of proteolytic...
A mild, scalable (kg) metal-free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access valuable from simple acid feedstocks. This robust method relies on alternating polarity maintain the quality electrode surface local pH, providing a deeper understanding Hofer-Moest process with unprecedented chemoselectivity.
Abstract A mild, scalable (kg) metal‐free electrochemical decarboxylation of alkyl carboxylic acids to olefins is disclosed. Numerous applications are presented wherein this transformation can simplify alkene synthesis and provide alternative synthetic access valuable from simple acid feedstocks. This robust method relies on alternating polarity maintain the quality electrode surface local pH, providing a deeper understanding Hofer‐Moest process with unprecedented chemoselectivity.