Basal laminar deposit (BLamD) is a consistent finding in age-related macular degeneration (AMD). We quantified BLamD thickness, appearance, and topography eyes of aged donors with without AMD evaluated its relationship to other components the retinal pigment epithelium-basal lamina/Bruch's membrane (RPE-BL-BrM) complex.Donor (n = 132) were classified as normal 54), early intermediate 24), geographic atrophy (GA; n 13), neovascular (NV; 41). In high-resolution histology, we assessed RPE,...

We evaluate the impact of test target location in assessing rod-mediated dark adaptation (RMDA) along transition from normal aging to intermediate age-related macular degeneration (AMD). consider whether RMDA slows because locations are near mechanisms leading or resulting high-risk extracellular deposits. Soft drusen cluster under fovea and extend inner ring ETDRS grid where rods sparse. Subretinal drusenoid deposits (SDDs) appear first outer superior subfield rod photoreceptors maximal...

Purpose: Lack of valid end points impedes developing therapeutic strategies for early age-related macular degeneration (AMD). Delayed rod-mediated dark adaptation (RMDA) is the first functional biomarker incident AMD. The relationship between RMDA and status outer retinal bands on optical coherence tomography (OCT) have not been well defined. This study aims to characterize these relationships in intermediate Methods: Baseline data from 476 participants was assessed including eyes with AMD...

Purpose: Lipofuscin and melanolipofuscin organelles in retinal pigment epithelium (RPE) cells are signal sources for clinical fundus autofluorescence (AF). To elucidate the subcellular basis of AF imaging, we identified, characterized, quantified frequency RPE morphology phenotypes donor eyes with age-related macular degeneration (AMD). Methods: In 25 RPE–Bruch's membrane flat mounts from eyes, analyzed 0.4-μm z-stack epifluorescence images stained phalloidin actin cytoskeleton. Using a...

Abstract Background Age-related macular degeneration (AMD), a leading cause of irreversible vision impairment in the United States and globally, is disease photoreceptor support system involving retinal pigment epithelium (RPE), Bruch’s membrane, choriocapillaris setting characteristic extracellular deposits between outer cells their blood supply. Research has clearly documented selective vulnerability rod photoreceptors rod-mediated (scotopic) early AMD, including delayed dark adaptation...

Purpose: We hypothesize the first visual dysfunction in transitioning to early and intermediate age-related macular degeneration (AMD) is delayed rod-mediated dark adaptation (RMDA), owing impaired photoreceptor sustenance from circulation. This analysis Alabama Study on Early Age-related Macular Degeneration 2 provides insight our framework's validity, comparing RMDA other tests among older normal, early, AMD eyes. Methods: disease severity was determined via fundus photos using Age-Related...

Purpose: Progress toward treatment and prevention of age-related macular degeneration (AMD) requires imaging end points that relate to vision. We investigated choriocapillaris flow signal deficits (FD%) visual function in eyes individuals aged ≥60 years, with without AMD. Methods: One eye each participant the baseline visit Alabama Study on Early Age-Related Macular Degeneration 2 (ALSTAR2; NCT04112667) was studied. AMD presence severity determined using Eye Disease (AREDS) grading system....

Purpose: Subretinal drusenoid deposits (SDD) first appear in the rod-rich perifovea and can extend to cone-rich fovea. To refine spatial relationship of visual dysfunction with SDD burden, we determined topography mesopic scotopic light sensitivity participants non-neovascular AMD without SDD. Methods: Thirty-three subjects were classified into three groups: normal (n = 9), AMD–Drusen (with drusen SDD; n 12), AMD–SDD (predominantly 12). Mesopic microperimetry performed using 68 targets...

The aims of the study were to describe baseline quantitative (short-wavelength) autofluorescence (qAF) findings in a large pseudophakic cohort at age-related macular degeneration (AMD)'s beginnings and assess qAF8 as an outcome measure evaluate Age-Related Eye Disease Study (AREDS) Beckman grading systems.

Research on Alzheimer's disease (AD) and precursor states demonstrates a thinner retinal nerve fiber layer (NFL) compared to age-similar controls. Because AD age-related macular degeneration (AMD) both impact older adults share risk factors, we asked if thicknesses, including NFL, are associated with cognition in AMD.

Federally Qualified Health Centers (FQHCs) are safety-net primary health care clinics in the US serving medically underserved areas and populations. We administered National Eye Institute Visual Function Questionnaire - 9 (VFQ-9), a vision-targeted, health-related quality of life questionnaire, to patients 3 FQHCs rural Alabama at risk for glaucoma. examined demographic factors self-reported eye conditions associated with VFQ-9 scores. The (score range 0-100) was at-risk glaucoma including...

Purpose: To advance metabolic imaging of the high-risk macula lutea by quantifying topography macular pigment optical density (MPOD), measured with two-wavelength autofluorescence (2WAF), and quantitative (short-wavelength) (qAF) intensity, which share same signal source cross-retinal light path, in aging, early (e), intermediate (i) age-related degeneration (AMD). Methods: 2WAF qAF images 384 pseudophakic eyes 230 persons (mean age, 74.2 ± 5.7 years; 145 female) from ALSTAR2 (AREDS 9-step...

Background: Yoga has become more popular among people in the United States and been touted by both yoga participants as well some physicians researchers for its health benefits. While benefits have studied, frequency of injury not documented. Purpose: Injury incidence, rates, types associated with quantified. This study estimates US yoga-associated incidence characterizes type over a 13-year period. Study Design: Descriptive epidemiology study. Methods: Data from National Electronic...

Purpose To determine if computed tomographic (CT) metrics of bone mineral density and muscle mass can improve the prediction noncancer death in men with localized prostate cancer. Materials Methods Institutional review board approval was obtained, waiver informed consent. All patients who underwent radiation therapy for cancer between 2001 2012 height, weight, past medical history documented CT that included L4-5 vertebral interspace were included. On a single axial section obtained at...

Government motor vehicle crash reports used in the study of driver safety can be biased and incomplete. Naturalistic driving methods using in-vehicle instrumentation have been developed recent years to objectively measure crashes near as they occur on road video kinematic data.To examine visual risk factors associated with at-fault among older drivers, most whom age-related eye conditions vision impairment.This prospective cohort was conducted at an academic ophthalmology clinic from January...

Purpose: In aging and early-intermediate age-related macular degeneration (AMD), rod-mediated dark adaptation (RMDA) slows more at 5° superior than 12°. Using optical coherence tomography angiography (OCTA), we asked whether choriocapillaris flow deficits are related to distance from the fovea. Methods: Persons ≥60 years stratified for AMD via Age-Related Eye Disease Study's nine-step system underwent RMDA testing. Two adjacent 4.4° × OCTA slabs were centered on fovea 12° superior. Flow...

In AMD, rod-mediated dark adaptation (RMDA) at 5° eccentricity is slower in eyes with subretinal drusenoid deposits (SDDs) than without. Here we quantified SDD burden using supervised deep learning for comparison to vision and photoreceptor topography.

Objective Previous studies have reported that children are at risk of severe injuries from exposure to laundry detergent pods. For the first time, this study sought compare demographic and characteristics among exposed pod non-pod detergents presenting emergency departments (EDs). Methods Data National Electronic Injury Surveillance System (NEISS) 2012–2014 were used. All observations with involving (NEISS code 0949) included in study. The χ 2 test was used for bivariate analysis logistic...

Purpose: We assessed the association between abundance of macular xanthophyll carotenoid pigment using dual-wavelength autofluorescence and multimodal vision testing including rod-mediated dark adaptation (RMDA), a measure retinoid re-supply, in adults ≥60 years old with without age-related degeneration (AMD). Methods: AMD severity was determined nine-step Age-Related Eye Disease Study grading. Tests probed cones (best-corrected visual acuity, contrast sensitivity), rods (low-luminance...

Photoreceptor (PR) outer segments, retinal pigment epithelium apical processes, and inter-PR matrix contribute to the interdigitation zone (IZ) of optical coherence tomography (OCT). We hypothesize that this interface degrades over adulthood, in concert with a delay rod mediated dark adaptation (RMDA). To explore idea, we determined IZ discernibility RMDA younger older adults.