A5084988035- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac and Coronary Surgery Techniques
- Acute Ischemic Stroke Management
- Metal complexes synthesis and properties
- Stroke Rehabilitation and Recovery
- Venous Thromboembolism Diagnosis and Management
- Dementia and Cognitive Impairment Research
- Cardiomyopathy and Myosin Studies
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Health and Well-being Studies
- Advanced battery technologies research
- Gastroesophageal reflux and treatments
Amsterdam University Medical Centers
2020-2025
University of Amsterdam
2020-2025
Amsterdam UMC Location University of Amsterdam
2020-2022
John Radcliffe Hospital
2021
University of Oxford
2021
Amsterdam Neuroscience
2020
Transcatheter aortic valve replacement (TAVR) harbors the risk of periprocedural complications that require emergent cardiac surgery, or "surgical bailout." Surgical bailout intends to be lifesaving but is associated with high mortality. This has given rise discussion on necessity surgical backup during TAVR. Therefore, recent studies in contemporary TAVR patients are warranted. study aimed assess incidence, trends, and clinical outcomes undergoing transfemoral The CENTER2 (Cerebrovascular...
Cerebrovascular events remain one of the most devastating complications transcatheter aortic valve implantation (TAVI). Data from real-world contemporary cohorts on longitudinal trends and outcomes limited. The aim this study was to assess incidence, temporal trends, predictors, cerebrovascular following transfemoral TAVI.
The use of valve-in-valve transcatheter aortic valve implantation (ViV-TAVI) is increasing, but studies evaluating clinical outcomes in these patients are scarce. Also, there limited data to guide the choice type ViV-TAVI. Therefore, this CENTER-study evaluated with ViV-TAVI compared native TAVI (NV-TAVI). In addition, we treated self-expandable versus balloon-expandable valves. A total 256 and 11333 NV-TAVI were matched 1:2 using propensity score matching, resulting 512 NV-TAVI. Mean age...
BACKGROUND Transcatheter aortic valve implantation (TAVI) is a minimally invasive, life‐saving treatment for patients with severe stenosis that improves quality of life. We examined cardiac output and cerebral blood flow in undergoing TAVI to test the hypothesis improved after associated an increase flow. DESIGN Prospective cohort study. SETTING European high‐volume tertiary multidisciplinary care. PARTICIPANTS Thirty‐one (78.3 ± 4.6 years; 61% female) symptomatic stenosis. MEASUREMENTS...
[Figure: see text].
Background: Both balloon-expandable (BE) and self-expandable (SE) valves for transcatheter aortic valve implantation (TAVI) are broadly used in clinical practice. However, adequately powered randomized controlled trials comparing these two designs lacking. Methods: The CENTER-study included 12,381 patients undergoing transfemoral TAVI. Patients TAVI with a BE-valve (n = 4096) were compared to an SE-valve after propensity score matching. Clinical outcomes including one-year mortality stroke...
Abstract Background Approximately one-third of patients with symptomatic severe aortic valve stenosis who are scheduled for transcatheter implantation (TAVI) have some degree cognitive impairment. TAVI may negative effects due to periprocedural micro-emboli inducing cerebral infarction. On the contrary, also positive increases in cardiac output and blood flow (CBF). However, studies that systematically assess these scarce. Therefore, main aim this study is outcomes undergoing TAVI. Study...
ObjectiveThis study sought to investigate the effect of body mass index on outcomes in patients with severe aortic valve stenosis undergoing transcatheter implantation.MethodsA total 12,381 transfemoral implantation were divided into categories: underweight (<18.5 kg/m2), normal weight (18.5-24.9 overweight (25.0-29.9 and obesity (>30 kg/m2). Primary endpoints differences 30-day 1-year all-cause mortality. Secondary included all other clinical such as stroke. Univariate multivariate odds...
Abstract Background Diabetes Mellitus (DM) affects a third of patients with symptomatic severe aortic valve stenosis undergoing transcatheter implantation (TAVI). DM is well-known risk factor for cardiac surgery, but its prognostic impact in TAVI remains controversial. This study aimed to evaluate outcomes diabetic TAVI. Methods multicentre registry includes data > 12,000 transfemoral We assessed baseline patient characteristics and clinical without DM. Clinical were defined by the second...
Transfemoral (TF) access is default in transcatheter aortic valve implantation (TAVI). Transaxillary (TAx) has been shown to be a safe alternative case of prohibitive iliofemoral anatomy, but whether TAx as preferred similar safety and efficacy TF unknown. The aim this study was compare outcomes between patients treated with self-expanding devices using or route TAVI.A single center cohort 354 multi-center 5980 were compared. Propensity score matching used reduce selection bias potential...
Abstract A third of patients diagnosed with symptomatic severe aortic valve stenosis and scheduled for transcatheter implantation (TAVI) exhibit some level cognitive impairment. The prospective CAPITA study aimed to systematically evaluate the impact TAVI on cerebral outcomes in undergoing procedure. In this report, we focus identification new incidence white matter hyperintensities (WMH) correlation changes functioning. (CArdiac OutPut, Cerebral Blood Flow Cognition Patients With Severe...
Abstract Background Heart rate variability (HRV) is indicative of autonomic balance. High HRV during sinus rhythm associated with reduced morbidity and mortality across a wide range health disorders. Listening to music has been shown induce psychological physiological responses that increase HRV, mechanism currently employed in therapy reduce anxiety post-operative pain. However, it remains unclear which characteristics have the most positive effect on HRV. Purpose This study aimed assess...
Abstract Background Cognitive impairment is prevalent in one third of patients with symptomatic severe aortic valve stenosis scheduled for transcatheter implantation (TAVI). How TAVI affects cognitive functioning these remains unknown. Purpose The CAPITA study (CArdiac outPut, cerebral blood flow and cognition In undergoing Transcatheter Aortic implantation) assessed the effects on lesions functioning. Methods a prospective outcomes 148 TAVI. One day before three months after TAVI, underwent...
Abstract Background Stroke is one of the most devastating complications after transcatheter aortic valve implantation (TAVI). The recent third Valve Academic Research Consortium (VARC-3) proposes new stroke terminology according to time between TAVI and onset. Purpose We aimed identify predictors assessed mortality in patients undergoing transfemoral complicated by acute, sub-acute early stroke. Methods Patients were included a global patient level database. Acute was defined as occurring...
Background:Historically, transfemoral (TF) access is the default in TAVI. Iliofemoral tortuosity, calcification and stenosis may impose risk of complications or preclude femoral access. When precluded, transsubclavian /transaxillary (Tax) has been shown to be a safe alternative. Whether TAx as primary site similar safety efficacy TF for TAVI procedures unknown. The aim this study was compare outcomes between patients with severe symptomatic aortic valve treated self-expanding devices using /...