Evidence indicates that menarche onset is associated with various health outcomes. Gastroesophageal reflux disease (GERD) a prevalent condition, which may be influenced by the age at (AAM). The study aims to investigate potential causal relationship between AAM and GERD. We conducted two-sample Mendelian randomization (MR) analysis utilizing single nucleotide polymorphisms (SNPs) derived from genome-wide association studies summary statistics for GERD as instrumental variables. Various MR...

Vanillin is a natural dietary flavoring widely used in the food industry. Colorectal cancer (CRC) one of common malignancies world. Chronic intestinal inflammation risk factor for development CRC. We have previously found that vanillin improves and prevents colitis mice. Here we evaluated inhibitory activities on mouse model colitis-induced Mice were challenged intraperitoneally with azoxymethane (AOM) orally dextran sodium sulfate (DSS). Various dosages administered 13 consecutive weeks....

Background: Migraine, a common neurological disorder, increases the risk of psychiatric disorders. Currently, efficacy conventional therapies is considered unsatisfactory. Acupuncture has been gaining popularity in treatment neuropsychiatric disease. This study aimed to investigate effect acupuncture on medical expenditure and depression anxiety migraine patients. Methods: Patients with were either selected for or no based 1:1 propensity score-matched method from Taiwanese National Health...

Paeonia lactiflora (PL) was widely used for pain relief, but its effects on migraine headaches remain unclear.The aim of the present study to investigate PL headaches.First, we found that frequently in Taiwan headache treatment based data from Taiwan's National Health Insurance Research Database. Migraine induced through intraperitoneal injection (i.p.) nitroglycerin (NTG, 10 mg/kg) rats. Pretreatment with administered orally 30 min prior NTG i.p. behavior observed by video-recordings....

Background Lactation insufficiency is a prevalent challenge for nursing mothers globally. There growing interest in the use of herbal galactagogues enhancing lactation, but their therapeutic efficacy and underlying mechanisms need thorough investigation. This study aims to investigate action addressing lactation by utilizing real-world data employing network analysis approach. Methods Our retrospective used Taiwan’s Longitudinal Health Insurance Database 2000 (LHID2000) identify 490 patients...

Abstract Problem Preeclampsia, a multifaceted condition during pregnancy characterized by hypertension and organ dysfunction, poses significant risks to both maternal fetal health. This study aims investigate the bidirectional causal relationship between peripheral immune cell phenotypes preeclampsia using two‐sample Mendelian randomization (MR) approach. Method of Genetic data from two sizable cohorts were utilized: 3757 individuals Sardinia, providing information on 731 traits, 200 929...

Female infertility affects a significant portion of the population, and recent studies suggest potential link between glycemic control reproductive health. This study investigates association serum glycated hemoglobin (HbA1c) levels female infertility, utilizing data from NHANES 2017–2020 Mendelian randomization (MR) analysis. A cross-sectional was conducted with 1578 women aged 20–45 who attempted pregnancy for at least one year. Serum HbA1c were analyzed in relation to status,...

Migraines are common headache disorders and risk factors for subsequent strokes. Acupuncture has been widely used in the treatment of migraines; however, few studies have examined whether its use reduces strokes migraineurs. This study explored long-term effects acupuncture on stroke migraineurs using national real-world data. We collected new migraine patients from Taiwan National Health Insurance Research Database (NHIRD) 1 January 2000 to 31 December 2017. Using 1:1 propensity-score...

The study aimed to investigate effect of auricular electrical stimulation (ES) on migraine. Migraine was induced in rats by intraperitoneal administration nitroglycerin (NTG, 10 mg/kg) three times. Auricular ES pretreatment performed for five consecutive days. behaviors were observed a video recording. could reverse the decrease total time spent exploratory (2619.0 ± 113.0 s vs 1581.7 217.6 s, p=0.0029) and locomotor (271.3 21.4 114.3 19.7 p=0.0135) also increase resting (19.0 10.6 154.3...

Postpartum depression (PPD) is one of most common postnatal complications, affecting approximately 10%–15% women after childbirth annually. Traditional Chinese medicine (TCM) has been gaining popularity as the choice treatment for PPD in Taiwan. Hence, our aim was to analyze utilization TCM among patients A cross‐sectional study conducted using a random sample million beneficiaries selected from Taiwanese National Health Insurance Research Database. We identified with who had received either...

Existing evidence has shown that patients with trigeminal neuralgia (TN) have a higher risk of developing depression than the normal population. Clinically, acupuncture been widely used to alleviate pain in TN. However, few studies explored use prevent Therefore, this study aimed apply national real-world data investigate long-term effect on TN.We recruited participants newly diagnosed TN from Taiwanese National Health Insurance Research Database between January 1, 2000 and December 31,...

Scutellaria baicalensis (SB), a traditional Chinese medicine, is commonly used for the treatment of inflammatory and painful conditions. The purpose present study was to examine effects SB on migraine.We examined clinical applications based data obtained from Taiwan's National Health Insurance Research Database confirmed that it frequently in Taiwan headaches. An experimental migraine model established rats by an intraperitoneal injection nitroglycerin (NTG, 10 mg/kg). Pretreatment with...

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age. Chinese herbal medicine (CHM), major branch traditional medicine, has been reported to exert beneficial effects on PCOS symptoms. However, the relationship between CHM use and risk coronary heart disease (CHD) patients with remains unclear. The study aimed investigate potential protective role CHD incidence understand prescription patterns for treatment. Methods: This retrospective...