A5029238783- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
Gentofte Hospital
2020-2024
University of Copenhagen
2020-2023
University of Mississippi Medical Center
2021
State Street (United States)
2021
American College of Allergy, Asthma and Immunology
2021
There is currently no insight into biomarkers that can predict the onset of pediatric atopic dermatitis (AD).Nested in a prospective birth cohort study examined occurrence physician-diagnosed AD 300 children, 44 random children with first year life were matched on sex and season who did not develop AD. Natural moisturizing factor (NMF), corneocyte surface protrusions, cytokines, free sphingoid bases (SBs) different chain lengths their ceramides analyzed from tape strips collected at 2 months...
It is unknown whether skin biomarkers collected in infancy can predict the onset of atopic dermatitis (AD) and be used future prevention trials to identify children at risk.This study sought examine AD during first 2 years life.This enrolled 300 term 150 preterm birth followed for until age years. Skin tape strips were 0 3 days months analyzed selected immune barrier biomarkers. Hazard ratio (HR) with 95% confidence interval (CI) using Cox regression was calculated risk AD.The 2-year...
It is currently unknown whether alterations in the skin microbiome exist before development of atopic dermatitis (AD). In this prospective Danish birth cohort 300 children, we examined during first 2 months life were associated with an increased risk AD years and its severity after adjustment for environmental factors selected chemokine natural moisturizing factor levels. We found no overall association between at age life. However, when restricting analysis to children least one parent...
Abstract Background Skin tape‐strips and biopsies are widely used methods for investigating the skin in atopic dermatitis (AD). Biopsies more commonly but can cause scarring pain, whereas noninvasive sample less tissue. The study evaluated performance of studying AD. Methods Whole‐transcriptome RNA‐sequencing was performed on paired collected from lesional non‐lesional AD patients ( n = 7) non‐AD controls 5). RNA yield, mapping efficiency, differentially expressed genes (DEGs) two...
This prospective birth cohort followed 150 preterm and 300 term newborns during the first year of life to assess possible differences in risk factors, age at onset, anatomical location, severity atopic dermatitis. Atopic dermatitis was diagnosed clinically, assessed using Eczema Area Severity Index (EASI). DNA analysed for filaggrin gene mutations. Parents were asked about environmental exposures emollient use. observed 21.2% children more common compared with (26.7% vs 11.7%, p < 0.001),...
Introduction Skin barrier development and dysfunction in premature mature newborns is important for the risk of atopic dermatitis (AD). Methods analysis The Barrier Atopic newBorns studY (BABY) Cohort a prospective birth cohort study 150 preterm children (gestational age (GA) below 37+0) 300 term (GA 37+0 to 41+6). assessed through transepidermal water loss, tape stripping, Raman-spectroscopy microbiome sampling. Clinical examinations are done DNA from buccal swabs collected genetic...
Staphylococcus aureus may worsen already established atopic dermatitis (AD), but its primary role in the aetiopathogenesis and severity of AD is unclear.To compare prevalence S. colonization early infancy children who developed during first 2 years life with did not.In this prospective birth cohort study, which included 450 infants, we analysed bacterial swabs collected from cheek skin at 0 months age. The development AD, severity, was diagnosed by a physician monitored prospectively for...