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Dongxu Li

ORCID: 0000-0001-7075-8333
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About
Contact & Profiles
A5013040175
Research Areas
  • Vibrio bacteria research studies
  • Protein Degradation and Inhibitors
  • Ubiquitin and proteasome pathways
  • Peptidase Inhibition and Analysis
  • Infections and bacterial resistance
  • Antibiotic Resistance in Bacteria

Tianjin University
 2024

University of North Carolina at Chapel Hill
 2021

 A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
OPENALEX - Publications 
Xufen Yu Dongxu Li Jithesh Kottur Yudao Shen Huen Suk Kim and 14 more Kwang‐Su Park Yi‐Hsuan Tsai Weida Gong Jun Wang Kyogo Suzuki Joel S. Parker Laura E. Herring H. Ümit Kanıskan Ling Cai Rinku Jain Jing Liu Aneel K. Aggarwal Gang Greg Wang Jian Jin

WDR5-degrader-E3 ligase ternary complex structure–based design led to a highly effective WDR5 degrader with robust in vivo antitumor activities.

10.1126/scitranslmed.abj1578 article EN Science Translational Medicine 2021-09-29
 Structural insight into the subclass B1 metallo-β-lactamase AFM-1
OPENALEX - Publications 
Wenqian Niu Ruijiao Ti Dongxu Li Ruihan Dong Jian Dong and 3 more Yiwen Ye Yunjie Xiao Zefang Wang

10.1016/j.bbrc.2024.150102 article EN Biochemical and Biophysical Research Communications 2024-05-11
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