A5019903114- Immunotherapy and Immune Responses
- Cell Adhesion Molecules Research
- Sphingolipid Metabolism and Signaling
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- NF-κB Signaling Pathways
- Monoclonal and Polyclonal Antibodies Research
- DNA Repair Mechanisms
- Immune Response and Inflammation
- Drug Transport and Resistance Mechanisms
- Diabetes and associated disorders
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Effects of Radiation Exposure
- Retinoids in leukemia and cellular processes
- Face and Expression Recognition
- Cholesterol and Lipid Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Immune cells in cancer
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Glycosylation and Glycoproteins Research
- Emotion and Mood Recognition
- Caveolin-1 and cellular processes
- Advanced Computing and Algorithms
National Institutes of Health
2015-2022
National Heart Lung and Blood Institute
2022
National Institute on Deafness and Other Communication Disorders
2017-2018
Royal Prince Alfred Hospital
2017
University of Michigan
2012-2013
Children's Hospital of Los Angeles
2002-2005
University of Southern California
2005
Abstract Head and neck squamous cell carcinoma (HNSCC) has been treated for decades with cisplatin chemotherapy, anti–PD-1 immunotherapy recently approved the treatment of this disease. However, preclinical studies how antitumor immunity in HNSCC is affected by alone or combination immunotherapies are lacking. Here, we show that sublethal doses may enhance antigen presentation T-cell killing vitro, though also upregulates tumor expression PD-L1 impair function at higher doses. In a syngeneic...
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor Apoptosis Proteins 1/2 (cIAP1/2), critical components the Tumor Necrosis Factor (TNF) Receptor signaling ASTX660 is a novel non-peptidomimetic antagonist cIAP1/2 XIAP under evaluation clinical trial for advanced solid tumors lymphomas. Herein, we show that ASTX660,...
Stress stimuli can mediate apoptosis by generation of the lipid second messenger, ceramide. Herein we investigate molecular mechanism ceramide signaling in endothelial induced fenretinide (<i>N</i>-(4-hydroxyphenyl)retinamide (4-HPR)). 4-HPR, a synthetic derivative retinoic acid that induces tumor cell lines, has been shown to have antiangiogenic effects, but these is largely unknown. We report 4-HPR was cytotoxic cells (50% cytotoxicity at 2.4 μm, 90% 5.36 μm) and caspase-dependent...
The efficacy of radiation therapy for lung cancer is limited by radiation-induced toxicity (RILT). Although tumor necrosis factor-alpha (TNF-α) signaling plays a critical role in RILT, the molecular regulators TNF-α production remain unknown. We investigated major regulator, Tristetraprolin (TTP), macrophages. For vitro studies we irradiated (4 Gy) either mouse macrophage cell line, MH-S or macrophages isolated from TTP knockout mice, and studied effects on levels. To study vivo relevance,...
Emotion detection plays a crucial role in fields such as biomedical applications, smart environments, brain-computer interfaces, communication, security, and safe driving. In this paper, we present novel approach for detecting emotions using electroencephalogram signals. The method employs convolutional neural network (CNN) the classifier, which is chosen from variety of intelligent algorithms. Discrete wavelet transform used to decompose signals into four frequency bands including theta,...
Abstract The efficacy of radiation therapy for lung cancer is limited by radiation-induced toxicity (RILT). Although tumor necrosis factor-alpha (TNF-α) signaling plays a critical role in RILT, the molecular regulators TNF-α production remain unknown. We investigated major regulator, Tristetraprolin (TTP), macrophages. an adenosine-uridine (AU) rich element (ARE) associated RNA binding protein, known to destabilize mRNA during lipopolysaccharide-induced inflammatory response and now we have...
Abstract Rationale: Cisplatin, which remains the most commonly used systemic drug for head and neck squamous cell carcinoma (HNSCC), reduces numbers of circulating immune cells. However, recent studies suggest that cisplatin may enhance some aspects anti-tumor immunity in tumor microenvironment. We previously found increases expression major histocompatibility (MHC) class I programmed death ligand 1 (PD-L1) HNSCC lines vitro. Methods: In current study, we investigated other components...