A5015533386- Mine drainage and remediation techniques
- Soil Carbon and Nitrogen Dynamics
- Heavy metals in environment
- Mycorrhizal Fungi and Plant Interactions
- Bacteriophages and microbial interactions
- Coal and Its By-products
- Forest Ecology and Biodiversity Studies
- Metal Extraction and Bioleaching
- Bauxite Residue and Utilization
- MicroRNA in disease regulation
- Microbial Community Ecology and Physiology
- Clay minerals and soil interactions
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- Arsenic contamination and mitigation
- Phosphorus and nutrient management
- RNA Interference and Gene Delivery
- Iron oxide chemistry and applications
- Environmental DNA in Biodiversity Studies
- Microbial Fuel Cells and Bioremediation
- Viral gastroenteritis research and epidemiology
- Natural Compounds in Disease Treatment
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Nanoparticles: synthesis and applications
National University of Singapore
2016-2024
Singapore-HUJ Alliance for Research and Enterprise
2024
Nanjing University
2021-2024
The University of Queensland
2014-2023
Fujian Medical University
2009-2021
Singapore Science Park
2020
Union Hospital
2009
Shaanxi Research Association for Women and Family
2000
The formation of water-stable aggregates in finely textured and polymineral magnetite Fe ore tailings is one the critical processes eco-engineering into soil-like substrates as a new way to rehabilitate tailings. Organic matter (OM) amendment plant colonization are considered be effective enhancing aggregation, but underlying mechanisms have not yet been elucidated. present study aimed characterize detailed changes physicochemistry, Fe-bearing mineralogy, organo-mineral interactions subject...
Dissolved organic matter (DOM) plays an important role in soil structure and biogeochemical function development, which are fundamental for the eco-engineering of tailings-soil formation to underpin sustainable tailings rehabilitation. In present study, we have characterized DOM composition its molecular changes alkaline Fe ore tailing primed with (OM) amendment plant colonization. The results demonstrated that microbial OM decomposition dramatically increased richness average weight, as...
The neutralization of strongly alkaline pH conditions and acceleration mineral weathering in Fe ore tailings have been identified as key prerequisites for eco-engineering tailings-soil formation sustainable mine site rehabilitation. Acidithiobacillus ferrooxidans has great potential neutralizing accelerating primary the but little information is available. This study aimed to investigate colonization A. its role elemental sulfur (S0) oxidation, neutralization, Fe-bearing through a microcosm...
Multidrug-resistant P. aeruginosa infections pose a serious public health threat due to the rise in antimicrobial resistance. Phage therapy has emerged as promising alternative. However, evolved various mechanisms thwart phage attacks, making it crucial decipher these resistance develop effective therapeutic strategies. In this study, we conducted forward-genetic screen of PA14 non-redundant transposon library (PA14NR) identify dominant-negative mutants displaying phage-resistant phenotypes....
Cyanobacteria are the major primary producers in both freshwater and marine environments. However, majority of cyanophages remain unknown due to limited number cyanophage isolates. In this study, we present a novel lytic cyanophage, PA-SR01, which was isolated from Singapore Serangoon Reservoir. To our knowledge, is first isolate that has been found infect cyanobacterium Pseudanabaena PA-SR01 narrow host range, short latent period, chloroform sensitive. Distinct isolates, tailless...
Arbuscular mycorrhizal (AM) fungi play an important role in organic matter (OM) stabilization Fe ore tailings for eco-engineered soil formation. However, little has been understood about the AM fungi-derived signature and organo-mineral interactions situ at submicron scale. In this study, a compartmentalized cultivation system was used to investigate of OM formation tailings. Particularly, microspectroscopic analyses including synchrotron-based transmission Fourier transform infrared (FTIR)...
Phytostabilization has been advocated as a promising approach to reduce mine tailings' adverse effects surrounding environment. With many years of efforts in both laboratory and field trials, organic amendments are found be essential tailing revegetation. Yet, the associate geochemical dynamics caused by different rarely examined. As reactive minerals usually rich tailings, changes induced would influence seepage management revegetation strategies. The present study aimed investigate Cu-Au...
• Plant biomass type influences AM role in organic carbon (OC) and nitrogen (N) sequestration Fe-ore tailings technosol. symbiosis enriched OC within macroaggregates of Lucerne hay amended tailings. increased N stabilization by minerals aggregates Sugarcane mulch Carboxyl-rich organics associated with Fe/Si-rich contributed to sequestration. Water deficit weakened the Arbuscular mycorrhizal (AM) plays an important matter (OM) aggregate formation eco-engineered technosol, but their may be...
A genetically encoded fluorescent protein sensor enabled monitoring the “Trojan-horse” type cytotoxicity of silver nanoparticles.
The present study aims to evaluate carbon recovery and analytical precision of two methods based on dry combustion for organic (OC) quantification in base metal mine tailings: (1) IC subtraction method (inorganic C(IC) measured subtracted from total C) (2) direct OC after acid pretreatment. Results showed effectively hydrolyzed a range minerals [calcium carbonate (CaCO3), magnesium (MgCO3), dolomite, magnesite, calcite] with satisfactory (as CO2 released) (87–103 percent). In the method, 5 M...
Tumor necrosis factor (TNF-α) is an important clinically tested cytokine that could induce autoimmune diseases and inflammation. Therefore, the anti-TNF-α therapy strategy was developed used therapeutically in various diseases, especially storm associated chimeric antigen receptor (CAR) T-cell antiviral therapy. Compare with other inhibitors, Nb (nanobody) has many unique advantages. Herein, we reported a novel humanized scaffold for library construction, which be soluble expressed...
Abstract Aims Nitrogen deficiency in eco-engineered technosol from iron (Fe) ore tailings limits the productivity of colonising soil microbes and pioneer plants, which are critical to further development technosol. Symbiotic biological N 2 fixation may be a strategy supply moderately alkaline early technosols since native legumes such as Acacia auriculiformis tolerant saline conditions those It is hypothesized that legume A. could form functional nodules fix when grown technosols. Methods...
Increasing evidence suggested that dysregulated miR-154 in several tumor tissues is involved the clinical progress of cancers patients. The objective this study was to explore expression pattern and its potential effects human melanoma.Microarray data from GEO datasets were analyzed identify differentially expressed miRNAs. Real Time-Polymerase Chain Reaction (RT-PCR) performed determine expressions melanoma cell lines tissues. associations between levels studied using a series statistical...