A5079349139- Nanoplatforms for cancer theranostics
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Nanomaterials for catalytic reactions
- Catalysis and Hydrodesulfurization Studies
- Immune cells in cancer
- Catalytic Processes in Materials Science
- Photodynamic Therapy Research Studies
- Luminescence and Fluorescent Materials
- Tissue Engineering and Regenerative Medicine
- Extracellular vesicles in disease
- Innovative Microfluidic and Catalytic Techniques Innovation
- Psoriasis: Treatment and Pathogenesis
- Atrial Fibrillation Management and Outcomes
- Wound Healing and Treatments
- Advanced Photocatalysis Techniques
- Inflammatory mediators and NSAID effects
- Cancer, Stress, Anesthesia, and Immune Response
- Pain Management and Opioid Use
- Copper-based nanomaterials and applications
- Cardiac Arrhythmias and Treatments
- Brain Metastases and Treatment
- Advancements in Transdermal Drug Delivery
- Microfluidic and Bio-sensing Technologies
- RNA Interference and Gene Delivery
Sun Yat-sen University
2022-2025
Huazhong University of Science and Technology
2025
Union Hospital
2025
Hebei University of Technology
2023-2024
Taiyuan University of Technology
2023
Abstract Peripheral nerve block is performed for precise pain control and lesser side effects after surgery by reducing opioid consumption. Injectable hydrogel delivery systems with high biosafety moisture content have good clinical application prospects local anesthetic delivery. However, how to achieve drug loading long‐term controlled release of water‐soluble narcotic drugs remains a big challenge. In this study, heterogeneous microspheres an injectable gel‐matrix composite system are...
Surgical resection remains the mainstay of melanoma treatment. However, due to difficulties in controlling tumor recurrence and wound healing simultaneously, high postoperative rates reconstruction remain most significant challenges. As a result, heterogeneous hybrid hydrogel scaffold was designed this work achieve sequential photothermal therapy chemotherapy for inhibition healing. A 3D printing platform used create SA-GG@PDA scaffold, which prepared from bioink consisting sodium alginate...
Photodynamic therapy (PDT) has emerged as an efficient approach for non-invasive cancer treatment. However, organic small-molecule photosensitizers are often associated with defects in hydrophobicity, poor photostability, and aggregation-caused quenching, which limit their application. Usually, the carrier-assisted drug delivery system is a common strategy to solve above obstacles, but additional carrier material could increase risk of potential biological toxicity. The carrier-free easy...
Sonodynamic therapy (SDT), which involves the activation of sonosensitizers to generate cytotoxic reactive oxygen species under ultrasound irradiation, is a promising noninvasive modality for cancer treatment. However, clinical translational application SDT impeded by lack efficient sonosensitizers, inefficient accumulation at tumor sites, and complicated immunosuppressive microenvironment. Herein, we developed facilely synthesized multifunctional porous organic polymer nanosonosensitizer...
Sonodynamic therapy (SDT), which is non-invasive and controllable has the potential to treat triple-negative breast cancer (TNBC). However, hypoxia immunosuppressive tumor microenvironment (TME) often block production of reactive oxygen species induction SDT-activated immunogenic cell death, thus limiting activation adaptive immune responses. To alleviate these challenges, we proposed development a multifunctional biomimetic nanoplatform (mTSeIR), was designed with diselenide-conjugated...
Tumor-draining lymph nodes (TDLNs) are the primary sites of eliciting anti-tumor immunity, which play an important role in controlling tumor progression and metastasis. However, immunosuppressive microenvironment TDLNs propels formation pre-metastatic niche, immunocytes dysfunctional, high expression programmed death-ligand 1 (PD-L1) on dendritic cells (DCs) restricts activation cytotoxic T lymphocytes. Herein, engineered exosomes (EmDEX@GA) developed for locoregional immunomodulation TDLNs....
Natural killer (NK) cells are widely involved in the field of tumor immunotherapy due to their unique killing ability. However, durability and efficacy NK-cell monotherapy facing great challenges owing limitation immunosuppressive microenvironment (TME). NK cell-derived exosomes (Neo) not only play an innate immunomodulatory role similar but also emerge as promising antitumor nanocarriers. In this study, engineered Neo (R@Neo-MN) was designed that encapsulates multifunctional drug (Raddeanin...
Abstract Obstructions can occur during any stage of colorectal cancer (CRC) and correspond with poor prognosis. Obstructive (OCRC) is harder exhibits increased tumor budding proliferation myofibroblasts compared to non-obstructive CRC, suggesting that the occurrence obstruction may be related extracellular matrix (ECM) remodeling. Here, we found CRC OCRC samples differed substantially in ECM composition, specifically collagen (newly formed mature) proteoglycans (including glycosaminoglycan,...
Image-guided thermal ablation (TA), which is less invasive, has been widely applied for treating various kinds of tumors. However, TA still poses the potential risk damage to sensitive tissue nearby. Therefore, an adjunctive thermoprotective hydrodissection technique with constant injection 5% glucose (5% Glu) currently adopted clinical application, but this may be hazardous humans. In study, a multifunctional hyaluronic acid-based hydrogel (HA-Dc) was developed hydrodissection. Compared Glu...
A triangular multi-chamber tumor-on-a-chip platform simulates the key biological microenvironment parameters affecting dynamic transport of nanoparticles and drugs, including culture, bionic ECMs 3D tumor spheroids.
The compound droplet consists of the inner and outer droplets. droplet's ability to isolate contents from its surroundings makes applications such as drug delivery, cell encapsulation, sorting possible. Here, we experimentally explore transport at different Reynolds numbers, viscosity ratios, volume ratios. Compound droplets have a longer dimensionless distance along X-axis than single-phase numbers 44 366. When number is increased 81.2 243.7, maximum becomes 2.04 times. As Re increases,...
Porphyrin-based photosensitizers are extensively utilized in the realm of photodynamic therapy, capitalizing on their advantageous optical, chemical, and electronic properties. Nonetheless, application is often constrained by pronounced hydrophobicity. Structures with a high load capacity excellent biocompatibility preferred options to circumvent this obstacle. Herein, we constructed novel porphyrin–camptothecin (CPT) polymer, which composed amphiphilic oxazoline segments, drug monomers...
Image-guided thermal ablation (TA), which is less invasive, has been widely applied for treating various kinds of tumors. However, TA still poses the potential risk damage to sensitive tissue nearby. Therefore, an adjunctive thermoprotective hydrodissection technique with constant injection 5% glucose (5% Glu) currently adopted clinical application, but this may be hazardous humans. In study, a multifunctional hyaluronic acid-based hydrogel (HA-Dc) was developed hydrodissection. Compared Glu...
Background and objectives: Concurrent atrial ablation is a widely accepted procedure during cardiac surgery to treat fibrillation.Success rate varies according different disease population, techniques used, definition applied.Although commonly performed, data results in Chinese population are lacking.Methods: From 2005 2009, 122 consecutive patients with chronic fibrillation associated other problem had undergone modified maze III as concomitant surgical ablation.Clinical operative were...