A5015353817- Adrenal Hormones and Disorders
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Monoclonal and Polyclonal Antibodies Research
- Sepsis Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Education, Healthcare and Sociology Research
- Magnesium in Health and Disease
- Immunotherapy and Immune Responses
- Hormonal Regulation and Hypertension
- Platelet Disorders and Treatments
- Myasthenia Gravis and Thymoma
- Blood groups and transfusion
- RNA Interference and Gene Delivery
- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Systemic Lupus Erythematosus Research
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related Molecular Pathways
- Erythrocyte Function and Pathophysiology
- Hematopoietic Stem Cell Transplantation
- Dermatological and COVID-19 studies
- Silymarin and Mushroom Poisoning
Haukeland University Hospital
2012-2024
University of Bergen
2000-2023
National Academy of Medicine
2004
University of Tübingen
1996
Autoimmune polyendocrine syndrome type 1 (APS1) is a childhood-onset monogenic disease defined by the presence of two three major components: hypoparathyroidism, primary adrenocortical insufficiency, and chronic mucocutaneous candidiasis (CMC). Information on longitudinal follow-up APS1 sparse. To describe phenotypes correlate clinical features with autoantibody profiles autoimmune regulator (AIRE) mutations during extended (1996–2016). All known Norwegian patients APS1. Fifty-two from 34...
High titer autoantibodies produced by B lymphocytes are clinically important features of many common autoimmune diseases. APECED patients with deficient regulator (AIRE) gene display a broad repertoire high autoantibodies, including some which pathognomonic for major AIRE deficiency severely reduces thymic expression gene-products ordinarily restricted to discrete peripheral tissues, and developing T cells reactive those not inactivated during their development. However, the extent...
Autoimmune polyendocrine syndrome type 1 (APS-1) is caused by mutations in the autoimmune regulator (AIRE) gene. Most patients present with severe chronic mucocutaneous candidiasis and organ-specific autoimmunity from early childhood, but clinical picture highly variable. AIRE crucial for negative selection of T cells, scrutiny different patient has previously highlighted many its molecular mechanisms. In a milder adult-onset phenotype sharing mutation canonical donor splice site intron 7...
Abstract Background Early balanced transfusion is associated with improved outcome in haemorrhagic shock patients. This study describes the implementation and evaluates safety of a whole blood program civilian helicopter emergency medical service (HEMS). Methods prospective observational was performed over 5-year period at HEMS-Bergen, Norway. Patients receiving out hospital low-titre Group O (LTOWB) or other components were included. Two LTOWB units produced weekly rotated to HEMS for...
Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The study included 60 patients; 35 fulfilled most recent 2016 Sepsis-3 criteria whereas remaining 25 only previous Sepsis-2 and could therefore be classified as having systemic inflammatory syndrome (SIRS). A total of 1011 identified metabolites were detected in our samples....
Hypomagnesemia can be caused by a wide range of diseases (e.g. gastrointestinal disorders, kidney or endocrine disorders), but it also side effect several drugs. It asymptomatic cause many different clinical symptoms, and the manifestations mainly depend on rate development rather than actual serum magnesium concentration. We here present 40-year-old female patient with Torsade de pointes ventricular tachycardia cardiac arrest severe hypomagnesemia as an adverse proton pump inhibitor omeprazole.
Proliferative responses and cytokine secretion were compared when AML blasts cultured in the three serum-free media, X-Vivo 10, 15, defined medium (IMDM with mercaptoethanol, low-density lipoprotein, albumin, transferrin) media containing 10% inactivated fetal bovine serum (FBS). The following blast functions investigated: (a) constitutive secretion, (b) autonomous cytokine-dependent proliferation, (c) accessory cell function during T activation. Constitutive differed markedly using...
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated systemic/serum lipidomic profile at time of hospital admission for patients with bacterial sepsis. The study included 60 patients; 35 fulfilled most recent 2016 Sepsis-3 criteria (referred Sepsis-3) whereas remaining 25 had sepsis only according previous Sepsis-2 definition and could be classified having Systemic Inflammatory Response Syndrome...
Background: Autoimmune polyendocrine syndrome type-1 (APS-1) is a rare, childhood onset disease caused by mutations in the Regulator gene. The phenotypic expression highly variable and includes manifestations oral cavity, including mucocutaneous candidiasis. Increasing evidence suggests potential role of skin, gut microbiotas pathogenesis autoimmunity. To date, no information exists regarding microbiota APS-1.Objective: assess bacterial whole saliva APS-1 patients using high throughput...
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) or polyendocrine syndrome type-1 (APS-1) (APECED, OMIM 240300) is a rare, childhood onset, monogenic disease caused by mutations in the Regulator (AIRE) gene. The overall mortality increased compared to general population and major cause of death includes malignant diseases, especially oral esophageal cancers. We here present case series four APS-1 patients with tongue cancers, an entity not described detail previously....
Abstract Autoantibodies against the ribosomal P proteins are related to cell death and tissue destruction frequently exhibited in patients with systemic lupus erythematosus (SLE). In an attempt explore effect of on induction anti‐P autoantibodies, we searched for autoantibodies by enzyme‐linked immunosorbent assay 201 antinuclear antibody (ANA)‐positive individuals, 10 treated kidney SLE 45 acute leukaemia undergoing intensive chemotherapy. The autoantibody reactivity was further...
Key Clinical Message The diagnosis of Lyme neuroborreliosis should be considered whenever a patient presents with neurological symptoms and comes from an endemic area. However, atypical clinical presentation occurs including gastrointestinal manifestations because autonomous dysfunction.
Autoimmune polyendocrine syndrome type I (APS-1) is a monogenic model disorder of organ-specific autoimmunity caused by mutations in the regulator (AIRE) gene. AIRE facilitates expression transcripts thymus, which essential for efficient removal dangerous self-reacting T cells and inducing regulatory (Tregs). Although reduced numbers function Tregs have been reported APS-I patients, impact deficiency on gene these unknown. Here, we report first time global transcriptional patterns isolated...