A5009655976- Sepsis Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Streptococcal Infections and Treatments
- Hematopoietic Stem Cell Transplantation
- Antimicrobial Resistance in Staphylococcus
- Blood Coagulation and Thrombosis Mechanisms
- Bacterial Identification and Susceptibility Testing
- Histone Deacetylase Inhibitors Research
- Platelet Disorders and Treatments
- Inflammation biomarkers and pathways
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Parvovirus B19 Infection Studies
- Diagnosis and Treatment of Venous Diseases
- Autoimmune and Inflammatory Disorders Research
- Protein Degradation and Inhibitors
- Otolaryngology and Infectious Diseases
- Chemokine receptors and signaling
- Immune Response and Inflammation
- Infections and bacterial resistance
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Machine Learning in Healthcare
- Facial Nerve Paralysis Treatment and Research
Haukeland University Hospital
2002-2024
University of Bergen
2002-2024
Karolinska University Hospital
2024
Smerteklinikken
2024
Karolinska Institutet
2024
Systemic levels of cytokines are altered during infection and sepsis. This prospective observational study aimed to investigate whether plasma multiple inflammatory mediators differed between sepsis patients with those without bacteremia the initial phase hospitalization. A total 80 proven bacterial no immunosuppression were included in study. Plasma samples collected within 24 h hospitalization, Luminex® analysis was performed on 35 mediators: 16 cytokines, six growth factors, four adhesion...
Necrotising soft-tissue infections affect the skin, subcutaneous tissue, superficial fascia, deep fascia or musculature. The are severe, spread rapidly and can result in extensive tissue loss. They rare, but have a high morbidity mortality rate. Early clinical recognition is crucial for outcome, rapid infection control by means of surgery targeted antibiotic treatment life-saving. There few prospective studies this type infection. Rapid identification condition uncertain effect several...
Here we present the case of a 37-year-old previously healthy man who developed fever, headache and unilateral, painful neck swelling while working offshore. He had no known contact with anyone COVID-19; however, due to ongoing pandemic, nasopharyngeal swab was performed, which positive for virus. After transfer hospital assessment his condition rapidly deteriorated, requiring admission intensive care COVID-19 myocarditis. One week after discharge he re-presented unilateral facial nerve...
Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During last decade, interest micro RNAs (miRNAs) in pathophysiological process cGVHD has increased. The objectives this study were to investigate a wide range serum miRNAs allografted patients and identify associations between cGVHD. included 79 allotransplanted adults, where samples obtained 1 year after allo-HSCT, miRNA profiling analysis...
Cytokines play a key role in regulation of normal and malignant hematopoiesis, angiogenesis, inflammation. Serum levels several cytokines are altered patients with hematologic malignancies, pretransplant cytokine seem to have prognostic impact treated allogeneic stem cell transplantation. However, the system constitutes an interacting functional network, it may therefore be more relevant look at serum profiles rather than single allotransplanted patients. We investigated pretransplantation...
One of the trademarks extraintestinal pathogenic Escherichia coli is adaptation metabolism and basic physiology to diverse host sites. However, little known how this common human pathogen adapts permit survival growth in blood. We used label-free quantitative proteomics characterize five E. strains purified from clinical blood cultures associated with sepsis urinary tract infections. Further comparison proteome profiles a reference uropathogenic strain 536 cultivated culture on two different...
Sepsis is a dysregulated host response to infection that causes potentially life-threatening organ dysfunction. We investigated the serum metabolomic profile at hospital admission for patients with bacterial sepsis. The study included 60 patients; 35 fulfilled most recent 2016 Sepsis-3 criteria whereas remaining 25 only previous Sepsis-2 and could therefore be classified as having systemic inflammatory syndrome (SIRS). A total of 1011 identified metabolites were detected in our samples....
Abstract Angiogenesis seems to be important both in the pathogenesis of acute myelogenous leukemia (AML) and for susceptibility AML blasts chemotherapy. Recent clinical studies even suggest that antiangiogenic therapy can induce disease control patients with relapse. In this context we have investigated profile systemic component angiogenic regulation by characterizing serum levels (i) regulators angiogenin, basic fibroblast growth factor (bFGF) endostatin; (ii) endothelial cell marker...
Abstract The initial evaluation of patients with suspected deep vein thrombosis includes the use biomarkers reflecting activation coagulation system. However, thromboembolic process and neighboring inflammatory responses also affect endothelial cells, cell markers may therefore be altered by disease. In present population-based single-center study, we investigated plasma levels endothelium-specific soluble E-selectin endocan in a consecutive unselected group 120 admitted to hospital for...
Chronic graft versus host disease (cGVHD) is a common long-term complication after allogeneic hematopoietic stem cell transplantation. The objective of our study was to compare the metabolic profiles for allotransplant recipients and thereby identify characteristics patients with treatment-requiring cGVHD. included 51 consecutive (29 men 22 women; median age: 44 years, range: 15-66 years) transplanted peripheral blood cells derived from human leukocyte antigen-matched family donors. All...
Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in disease may guide correct interventions and discovery of novel diagnostic targets. Plasma levels 37 mediators, leucocytes CRP 102 patients β-hemolytic NSTI derived a prospective Scandinavian multicentre study were compared those 23 cases Hierarchical cluster analyses also performed. Differences mediator between cellulitis...
Allogeneic stem cell transplantation is commonly used in the treatment of high-risk acute myeloid leukemia (AML). This intensive has a high early transplant-related mortality, and an additional significant cause death these patients later AML relapse. Retransplantation can be considered for minority patients, but only 10-20% selected then achieve long-term survival. Donor lymphocyte infusion (DLI) antileukemic effect, effect this usually lasts 3-4 months. A possible strategy to improve...
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. In the present study, we investigated systemic/serum lipidomic profile at time of hospital admission for patients with bacterial sepsis. The study included 60 patients; 35 fulfilled most recent 2016 Sepsis-3 criteria (referred Sepsis-3) whereas remaining 25 had sepsis only according previous Sepsis-2 definition and could be classified having Systemic Inflammatory Response Syndrome...
Abstract Objectives To develop and externally validate machine learning models for predicting microbial aetiology clinical endpoints, encompassing surgery, patient management, organ support in Necrotising Soft Tissue Infections (NSTI). Methods Predictive the presence of Group A Streptococcus (GAS) five endpoints (risk amputation, size skin defect, maximum defect size, length ICU stay, need renal replacement therapy) were built trained using data from prospective, international INFECT cohort...
Sepsis is one of the most common causes death in Norwegian hospitals. The condition often overlooked with treatment being delayed. Scoring systems to detect patients sepsis have mostly been studied emergency departments and more rarely on wards. objective this study was investigate ability various clinical scoring identify wards.The SIRS (Systemic Inflammatory Response Syndrome), qSOFA (quick Sequential Organ Failure Assessment) NEWS2 (National Early Warning Score 2) compared a adult...
Allogeneic stem cell transplantation is commonly used in the treatment of high-risk acute myeloid leukemia (AML). This intensive has a high early transplant-related mortality, and an additional significant cause death these patients later AML relapse. Retransplantation can be considered for minority patients, but only 10-20% selected then achieve long-term survival. Donor lymphocyte infusion (DLI) antileukemic effect, effect this usually lasts 3-4 months. A possible strategy to improve...