A5016745426- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Otolaryngology and Infectious Diseases
- Bacterial Identification and Susceptibility Testing
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Parvovirus B19 Infection Studies
- Neonatal and Maternal Infections
- Hip and Femur Fractures
- Rabies epidemiology and control
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Dermatological and COVID-19 studies
- Animal Virus Infections Studies
Haukeland University Hospital
2017-2024
University of Bergen
2017-2022
Abstract Background Necrotizing soft-tissue infections (NSTI) are life-threatening conditions often caused by β-hemolytic streptococci, group A Streptococcus (GAS) in particular. Optimal treatment is contentious. The INFECT cohort includes the largest set of prospectively enrolled streptococcal NSTI cases to date. Methods From 409 adults admitted with 5 clinical centers Scandinavia, patients culture-positive for GAS or dysgalactiae (SD) were selected. Risk factors identified comparison a...
Necrotising soft-tissue infections affect the skin, subcutaneous tissue, superficial fascia, deep fascia or musculature. The are severe, spread rapidly and can result in extensive tissue loss. They rare, but have a high morbidity mortality rate. Early clinical recognition is crucial for outcome, rapid infection control by means of surgery targeted antibiotic treatment life-saving. There few prospective studies this type infection. Rapid identification condition uncertain effect several...
Necrotizing soft tissue infections (NSTIs) are devastating caused by either a single pathogen, predominantly Streptococcus pyogenes, or multiple bacterial species. A better understanding of the pathogenic mechanisms underlying these different NSTI types could facilitate faster diagnostic and more effective therapeutic strategies. Here, we integrate microbial community profiling with host pathogen(s) transcriptional analysis in patient biopsies to dissect pathophysiology streptococcal...
Background: In the early 20th century, face was predominant site of cellulitis. Despite a relative decrease in incidence facial cellulitis, it is still common. There are few studies on this condition during last decades. The aim study to describe contemporary aetiological and clinical characteristics patients admitted hospital with non-suppurative cellulitis.Methods: Patients were included prospectively. Clinical details, comorbidities biochemistry results recorded. Investigations cultures...
Background: Skin and soft tissue infections (SSTIs) are increasing. Frequent over- under-treatment has been reported, including non-purulent SSTIs where cases demanding surgery or broad-spectrum therapy often hard to identify. Our aim was measure the predictive power of a modified severity score use it identify areas improvement in antimicrobial SSTIs.Methods: We prospectively included adult patients admitted hospital with SSTIs. A Dundee at admission calculated retrospectively, associations...
BACKGROUNDNecrotizing soft-tissue infections (NSTIs) are rapidly progressing frequently complicated by septic shock and associated with high mortality. Early diagnosis is critical for patient outcome, but challenging due to vague initial symptoms. Here, we identified predictive biomarkers NSTI clinical phenotypes outcomes using a prospective multicenter cohort.METHODSLuminex multiplex assays were used assess 36 soluble factors in plasma from patients positive microbiological cultures (n =...
Early stages with streptococcal necrotizing soft tissue infections (NSTIs) are often difficult to discern from cellulitis. Increased insight into inflammatory responses in disease may guide correct interventions and discovery of novel diagnostic targets. Plasma levels 37 mediators, leucocytes CRP 102 patients β-hemolytic NSTI derived a prospective Scandinavian multicentre study were compared those 23 cases Hierarchical cluster analyses also performed. Differences mediator between cellulitis...
Streptococcus pyogenes (group A streptococci; GAS) is the main causative pathogen of monomicrobial necrotizing soft tissue infections (NSTIs). To resist immuno-clearance, GAS adapt their genetic information and/or phenotype to surrounding environment. Hyper-virulent streptococcal pyrogenic exotoxin B (SpeB) negative variants caused by covRS mutations are enriched during infection. key driving force for this process bacterial Sda1 DNase.Bacterial infiltration, immune cell influx, necrosis and...
Abstract Background Necrotising soft tissue infections (NSTIs) are rapidly progressing bacterial usually caused by either several pathogens in unison (polymicrobial infections) or Streptococcus pyogenes (mono-microbial infection). These rare and associated with high mortality rates. However, the underlying pathogenic mechanisms this heterogeneous group remain elusive. Methods In study, we built interactomes at both population individual levels consisting of host-pathogen interactions...
Background: Varicella zoster virus (VZV) is a human neurotropic which commonly causes infection during childhood. Later in life it may reactivate as herpes zoster. We report rare manifestation of reactivation VZV presenting cutaneous vasculitis and varicella pneumonia lung transplant recipient. Case presentation: A 65 year old man was transplanted bilaterally for emphysema. Nine months post-transplant he presented with dyspnea vasculitis-like eruption. not suspected due to absence the...
Background: Varicella zoster virus (VZV) is a human neurotropic which commonly causes infection during childhood. Later in life it may reactivate as herpes zoster. We report rare manifestation of reactivation VZV presenting cutaneous vasculitis and varicella pneumonia lung transplant recipient. Case presentation: A 65 year old man was transplanted bilaterally for emphysema. Nine months post-transplant he presented with dyspnea vasculitis-like eruption. not suspected due to absence the...
Varicella-zoster virus (VZV) is a human neurotropic which commonly causes infection during childhood, presenting as chickenpox. Later in life it may reactivate herpes zoster. We report rare manifestation of reactivation VZV cutaneous vasculitis and varicella pneumonia lung transplant recipient.
Necrotizing soft tissue infections (NSTIs) are severe diseases with high morbidity and mortality. The diagnosis is challenging. Several guidelines recommend biopsies as an adjunct diagnostic in routine management, but neither biopsy sampling nor classification standardized or validated. We studied the quality of examination part diagnostics NSTIs.This was a retrospective cohort study adult patients undergoing surgery due to suspected NSTIs which taken management. Clinical data were reviewed....