A5031042005- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Mast cells and histamine
- Hematopoietic Stem Cell Transplantation
- Chronic Myeloid Leukemia Treatments
- Erythrocyte Function and Pathophysiology
- Eosinophilic Disorders and Syndromes
- Phagocytosis and Immune Regulation
- Advanced Biosensing Techniques and Applications
- Renal Diseases and Glomerulopathies
- Acute Lymphoblastic Leukemia research
- Genital Health and Disease
- Mesenchymal stem cell research
- Bacterial Identification and Susceptibility Testing
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Chronic Lymphocytic Leukemia Research
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Ethics in Clinical Research
- Infections and bacterial resistance
- Retinoids in leukemia and cellular processes
- Histiocytic Disorders and Treatments
- Blood disorders and treatments
- Hemoglobinopathies and Related Disorders
Haukeland University Hospital
2019-2024
University of Bergen
2020-2024
Chronic graft-versus-host disease (cGVHD) is the most common long-term complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). During last decade, interest micro RNAs (miRNAs) in pathophysiological process cGVHD has increased. The objectives this study were to investigate a wide range serum miRNAs allografted patients and identify associations between cGVHD. included 79 allotransplanted adults, where samples obtained 1 year after allo-HSCT, miRNA profiling analysis...
Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase implicated in cell migration and homing of hematopoietic cells to the niche, commonly overexpressed acute myeloid leukemia (AML). This can lead quiescence leukemic blasts niche reduced response therapy. We investigated Rac1 inhibitor EHop-016 on AML by assessing its effects MOLM-13 vitro zebrafish larvae, regarding motility therapeutic potential combination with daunorubicin (DNR). In assessment proliferation viability was measurement
The prognosis of acute myeloid leukemia (AML) is poor, especially for the elderly population. Targeted therapy with small molecules may be a potential strategy to overcome chemoresistance and improve survival in AML. We investigated inhibition signaling molecule ras-related C3 botulinum toxin substrate 1 (Rac1) cells derived from 79 consecutive AML patients, using five Rac1 inhibitors: ZINC69391, ITX3, EHOP-016, 1A-116, NSC23766. In vitro cell proliferation apoptosis assays assessment...
Acute myelogenous leukemia (AML) is a malignant disease of the hematopoietic system, characterized by rapid proliferation, dysregulated apoptosis, and block in differentiation leukemic bla...
Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a dismal prognosis. The cytoplasmic spleen tyrosine kinase (SYK) highly expressed by hematopoietic cells and has emerged as potential therapeutic target. In this study, we evaluated the in vitro antileukemic effects of five SYK inhibitors, fostamatinib, entospletinib, cerdulatinib, TAK-659, RO9021, consecutive AML patient cohort. All inhibitors demonstrated concentration-dependent antiproliferative effect, although...
Abstract We here present a case of 59-year-old man with Mondor’s disease, thrombophlebitis the superficial veins anterior chest wall. This occurred after patient had initiated extensive training walking poles, Nordic walking, probably predisposing to thrombosis. Underlying disease was ruled out, and treatment symptomatic. Physicians should be aware this condition in patients performing upper body workout.
Topic: 3. Acute myeloid leukemia - Biology & Translational Research Background: Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase signaling molecule implicated downstream of membrane receptors CXCR4 and CD44, which attract mediate contact the leukemic cells to bone marrow niche. Rac1 inhibition with lead compound EHOP-016 has potent antiproliferative effect (IC50 3µM) on patient-derived cells. Zebrafish larvae have emerged as relevant model study how compounds affect behavior...
Waldenström's macroglobulinemia (WM), characterized with monoclonal immunoglobulins of type M and lymphoplasmacytic lymphoma, is a rare clonal Bcell disorder. WM usually present as an indolent renal involvement is, in contrast to multiple myeloma, very rarely seen. We patient presenting severe nephritis nephrotic range proteinuria more than 9 g/day initial manifestations WM. Furthermore, we discuss diagnostic therapeutic approaches for this manifestation the disease, light recent research...
Background: Ras-related C3 botulinum toxin substrate 1 (Rac1) is a GTPase signaling molecule known to be overexpressed in many solid cancers and leukemia. Rac1 plays part several pathways regulating, e.g., cell migration, adhesion, proliferation. Recent studies have revealed activation widespread implication of the acute myeloid leukemia (AML), vitro inhibition AML lines induces apoptosis improves chemosensitivity. Aims: We studied effect on proliferation, apoptosis, cytokine release five...
The entity myelodysplastic syndrome/myeloproliferative neoplasm overlap syndrome is characterized by the coexistence of both myeloproliferative and features in bone marrow. Risk assessment treatment recommendations have not been standardized, clinicians rely on updated patient studies reviews to make decisions for approaches. Histopathological traditionally important, although last decade, several reported mutational profiles this rare disease. Here, we present a case, wherein presented with...