A5000913660- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Neurological Complications and Syndromes
- Cardiovascular Function and Risk Factors
- Chronic Myeloid Leukemia Treatments
- Renal Transplantation Outcomes and Treatments
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Cardiac Imaging and Diagnostics
- Sarcoidosis and Beryllium Toxicity Research
- Bone health and treatments
- IgG4-Related and Inflammatory Diseases
- Respiratory Support and Mechanisms
- Cardiomyopathy and Myosin Studies
- Phagocytosis and Immune Regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Aortic Thrombus and Embolism
- Research on Leishmaniasis Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular and Diving-Related Complications
- Pneumocystis jirovecii pneumonia detection and treatment
Sociedad Española de Cardiología
2021-2024
Hospital Italiano de Buenos Aires
1970-2024
University College London
2024
Instituto Universitario Hospital Italiano
2023
Consejo Nacional de Investigaciones Científicas y Técnicas
2023
Institute of Cardiology
2022
Transthyretin cardiac amyloidosis (ATTR-CA) is a progressive cardiomyopathy. The clinical course varies among individuals and there are no established measures to assess disease progression. goal of this study was the prognostic importance an increase in N-terminal pro–B-type natriuretic peptide (NT-proBNP) outpatient diuretic intensification (ODI) as markers progression large cohort patients with ATTR-CA. We evaluated landmark survival analysis based on worsening NT-proBNP requirement for...
Background: Aortic stenosis (AS) is currently the most common valvular disease, with an estimated prevalence of over 4% in octogenarians.Objective: To describe moderate-severe aortic patients wild type transthyretin amyloidosis (ATTRwt).Also, clinical features, echocardiographic characteristics and evolution.Method: Retrospective cohort diagnosis ATTRwt, belonging to Hospital Italiano de Buenos Aires Institutional Amyloidosis Registry, from 30/11/2007 31/05/2021.Patients follow up was...
Aortic stenosis (AS) is currently the most common valvular disease, with an estimated prevalence of over 4% in octogenarians.
La amiloidosis siempre ha representado un desafío diagnóstico. En el año 2020, Grupo de Estudio Amiloidosis (GEA), confeccionó la Guía Práctica Clínica para Diagnóstico Amiloidosis1-3. Nuevas líneas investigación se han desarrollado posteriormente. Esta revisión narrativa tiene como intención explorar estado del arte en diagnóstico amiloidosis. pacientes con recomienda tipificación proteína mediante espectrometría masa, técnica difícil ejecución por requerir microdisectores láser preparación...
Objective: To describe the evolution of serum free light chains (FLC) in period between orthotopic heart transplantation (OHT) and autologous stem cell (ASCT), hematological response one year after ASCT chemotherapy immunosuppressive treatment patients with AL amyloidosis.Method: Case series consecutive diagnosed amyloidosis who received OHT followed by from Institutional Registry Amyloidosis Italian Hospital Buenos Aires, January 2010 November 2021.FLC values transplants at post...
To estimate the prevalence of cardiac amyloidosis in patients with systemic amyloidosis. Compare survival rates based on whether they show involvement.
La amiloidosis AL es una enfermedad debida al depósito, en órganos y tejidos, de fibrillas formadas por depósito transtiretina poco frecuente se debe dicha proteína diversos aunque la afectación más cardíaca neurológica. Puede ser adquirida (antiguamente llamada “amiloidosis senil”) o hereditaria debido a mutaciones el gen que codifica para transtiretina.En 2020, Grupo Estudio Amiloidosis confeccionó guías práctica clínica tratamiento cardiomiopatía amiloidea transtiretina. Desde entonces...
Objectives. Patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) often experience poor outcomes due to the development of heart failure (HF). Tricuspid regurgitation (TR) has been found be correlated adverse in patients HF. This study aims assess whether presence significant TR is associated cardiac ATTR-CM. Materials and methods. Retrospective ATTR-CM enrolled Institutional Registry Amyloidosis (NCT01347047). were categorized based on (moderate or severe according current...
La amiloidosis por depósito de transtiretina es una enfermedad infrecuente y se debe al fibrillas dicha proteína en diversos tejidos, aunque la afectación más frecuente cardíaca neurológica. Puede ser adquirida (antiguamente llamada “amiloidosis senil”) o, menos frecuentemente, hereditaria debido a mutaciones el gen que codifica para (TTR). Una manifestación habitual TTR mutada (de ahora adelante ATTRv) polineuropatía amiloidótica familiar. En Hospital Italiano Buenos Aires, desde año 2010...
To describe the evolution of serum free light chains (FLC) in period between orthotopic heart transplantation (OHT) and autologous stem cell (ASCT), hematological response one year after ASCT chemotherapy immunosuppressive treatment patients with AL amyloidosis.Case series consecutive diagnosed amyloidosis who received OHT followed by from Institutional Registry Amyloidosis Italian Hospital Buenos Aires, January 2010 November 2021. FLC values transplants at post ASCT. Quantitative variables...
Amyloidosis is a systemic disorder produced by the deposition of insoluble protein fibrils that fold and deposit in myocardium. Patients with amyloidosis cardiac involvement have higher mortality than patients without involvement. The two most prevalent forms associated are AL amyloidosis, due to immunoglobulin light chains, ATTR transthyretin (TTR) mutated or senile form. This article aims review different imaging modalities (echocardiography, magnetic resonance imaging, nuclear medicine...
To describe the clinical and imaging characteristics of heart transplantation patients due to amyloidosis in a community institution.Descriptive case series consecutive with medical center. All diagnosis cardiac compromise receiving transplantation, performed period November 2008 February 2021, were included analysis.A total 16 included. The mean age was 59.9 years (± 10.2). 81.25% (n = 13) male. According type amyloidosis, 12 transplanted for AL 4 ATTR amyloidosis. most frequent...
The liver can be either compromised by infiltrative damage of amyloid, as it happens in AL and AA amyloidosis, or its cause, occurs transthyretin TTR-related amyloidosis. In the latter, synthesizes a defective variant TTR which has capacity for cardiac, neurological, renal damage, but function is preserved. This study aimed to describe clinical characteristics prognosis patients with involvement amyloidosis (AL AA) Retrospective cohort hepatic included Institutional Amyloidosis Registry...
La amiloidosis AL es una enfermedad debida al depósito, en órganos y tejidos, de fibrillas formadas por cadenas livianas producidas forma patológica plasmocitos clonales. Su tratamiento actualmente está orientado a erradicar el clon células plasmáticas; este históricamente se extrapoló tratamientos disponibles estudiados para otras discrasias sanguíneas.En año 2020, Grupo Estudio Amiloidosis (GEA) confeccionó distintas guías práctica clínica la AL.Desde entonces han publicado ensayos...
Objective:The study aims to estimate the prevalence of cardiac amyloidosis in patients with systemic amyloidosis.Compare survival rates based on whether they show involvement.Methods: A retrospective cohort from Institutional Amyloidosis Registry Hospital Italian Buenos Aires 2010 2019.Heart involvement is considered be presence symptoms and/or images consistent amyloidosis, and there no other reason explain it.Death for all causes were evaluated.The rate was estimated by Kaplan-Meier.Cox...