A5059283330- RNA Research and Splicing
- interferon and immune responses
- Heat shock proteins research
- Galectins and Cancer Biology
- X-ray Diffraction in Crystallography
- RNA modifications and cancer
- Multiferroics and related materials
- Genomics and Phylogenetic Studies
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Molten salt chemistry and electrochemical processes
- Cancer-related gene regulation
- Bacteriophages and microbial interactions
- Metalloenzymes and iron-sulfur proteins
- Advanced Condensed Matter Physics
- HIV Research and Treatment
- Magnetic Properties and Synthesis of Ferrites
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Chemical Thermodynamics and Molecular Structure
- Nuclear materials and radiation effects
- ATP Synthase and ATPases Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Structure and Dynamics
Max Planck Institute for Solid State Research
2019-2020
Max Planck Institute for Biophysical Chemistry
2018-2020
University of Göttingen
2015
Scripps Research Institute
2002
ABSTRACT The CXC chemokine gamma interferon (IFN-γ)-inducible protein CXCL10/IP-10 is markedly elevated in cerebrospinal fluid and brain of individuals infected with human immunodeficiency virus type 1 (HIV-1) implicated the pathogenesis HIV-associated dementia (HAD). To explore possible role HAD, we examined expression this other chemokines central nervous system (CNS) transgenic mice astrocyte-targeted HIV gp120 under control glial fibrillary acidic (GFAP) promoter, a murine model for...
Abstract Antibody-mediated immune responses rely on antigen recognition by the B cell receptor (BCR) and proper engagement of its intracellular signal effector proteins. Src homology (SH) 2 domain-containing leukocyte protein 65 kDa (SLP65) is key scaffold mediating BCR signaling. In resting cells, SLP65 colocalizes with Cbl-interacting 85 (CIN85) in cytoplasmic granules whose formation not fully understood. Here we show that effective activation requires tripartite phase separation SLP65,...
Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are proximal B-cell antigen receptor (BCR) signal effectors critical for proper immune responses. In association with intracellular vesicles, the two effector form phase separated prior to stimulation, thereby preparing B lymphocytes rapid effective activation upon BCR ligation. Within this tripartite system, 6 proline-rich motifs (PRMs) of...
Production and secretion of pro-metastatic proteins is a feature many tumor cells. The FAM3C interleukin-like epithelial-to-mesenchymal-transition (EMT) inducer (ILEI) has been shown to be strongly up-regulated in several cancers essential for formation metastasis epithelial cells, correlating with significant decrease overall survival colon breast cancer patients. ILEI seen interact the γ-secretase presenilin 1 subunit (PS1). However, not much known about mechanism-of-action or detailed...
Proline is prevalent in intrinsically disordered proteins (IDPs). NMR assignment of proline-rich IDPs a challenge due to low dispersion chemical shifts. We propose here new sensitivity-enhanced 4D experiments that correlate two pairs amide resonances are either consecutive (NHi–1, NHi) or flanking proline at position i–1 (NHi–2, NHi). The maximum 2-fold enhancement sensitivity achieved by employing coherence order-selective (COS) transfers incorporated unconventionally into the pulse...
Abstract Biomolecular condensates play a major role in cell compartmentalization, besides membrane-enclosed organelles. The multivalent SLP65 and CIN85 proteins are downstream B receptor (BCR)-signaling effectors, required for proper immune response. Both phase separate together with vesicles to form pre-signaling clusters. Within this tripartite system, six PRMs of interact promiscuously three SH3 domains the monomer, establishing 18 individual SH3-PRM interactions whose dissociation...
Clostridium sp. strain FS41 (DSM 6877) is a strictly anaerobic and Gram-positive spindle-shaped rod. This spore-forming bacterium able to degrade N-methylhydantoin, with N-carbamoylsarcosine sarcosine as intermediates. The genome consists of one replicon (6.28 Mb) harbors 5,735 predicted protein-coding genes.