A5044544432- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Chromosomal and Genetic Variations
- Genomics and Phylogenetic Studies
- Genetic and phenotypic traits in livestock
- Evolution and Genetic Dynamics
- Cancer Genomics and Diagnostics
- Animal Behavior and Reproduction
- Reflective Practices in Education
- Lymphoma Diagnosis and Treatment
- Animal Genetics and Reproduction
- Monoclonal and Polyclonal Antibodies Research
- Genetic factors in colorectal cancer
- Higher Education Learning Practices
- Ovarian cancer diagnosis and treatment
- Innovative Teaching and Learning Methods
University of Helsinki
2017-2024
We describe an integrative approach to improve contiguity and haploidy of a reference genome assembly demonstrate its impact with practical examples. With two novel features Lep-Anchor software combination dense linkage maps, overlap detection bridging long reads, we generated improved the nine-spined stickleback (Pungitius pungitius) genome. were able remove significant number haplotypic contigs, detect more genetic variation genome, especially that X chromosome. However, scaffolding cannot...
Abstract Map distance is one of the key measures in genetics and indicates expected number crossovers between two loci. estimated from observed recombination frequency using mapping functions, most widely used those, Haldane Kosambi, being developed at time when markers was low unobserved had a substantial effect on fractions. In contemporary high-density marker data, probability multiple adjacent loci negligible different functions yield same result, that is, equal to map Morgans. However,...
Abstract The nine-spined stickleback (Pungitius pungitius) has been increasingly used as a model system in studies of local adaptation and sex chromosome evolution but its current reference genome assembly is far from perfect, lacking distinct chromosomes. We generated an improved the (98.3% BUSCO completeness) with aid linked-read mapping. While new (v8) was similar size earlier version (v7), we were able to assign 4.4 times more contigs linkage groups improve contiguity genome. Moreover,...
Abstract Understanding what determines species and population differences in levels of genetic diversity has important implications for our understanding evolution, as well the conservation management wild populations. Previous comparative studies have emphasized roles linked selection, life-history trait variation genomic properties, rather than pure demography, determinants diversity. However, these findings are based on coarse estimates across a range highly diverged taxa, it is unclear...
Abstract Crossovers in meiosis have an important role sexual reproduction ensuring the segregation of chromosomes and shuffling genetic material. Despite their profound importance, little is known about heritability repeatability crossover rate wild. We studied variation outbred nine- (Pungitius pungitius) three-spined (Gasterosteus aculeatus) stickleback populations to estimate its (h2) (R). Based on interpreted from parent–F1-offspring linkage maps created single nucleotide polymorphism...
Summary We describe an integrative approach to improve contiguity and haploidy of a reference genome assembly demonstrate its impact with practical examples. With two novel features Lep-Anchor software combination dense linkage maps, overlap detection bridging long reads we generated improved the nine-spined stickleback ( Pungitius pungitius ) genome. were able remove significant number haplotypic contigs, detect more genetic variation genome, especially that X chromosome. However,...
Abstract Map distance is one of the key measures in genetics and indicates expected number crossovers between two loci. estimated from observed recombination frequency using mapping functions, most widely used those, Haldane Kosambi, being developed at time when markers was low unobserved had a substantial effect on fractions. In contemporary high-density marker data, probability multiple adjacent loci negligible different functions yield same result, that is, equal to map Morgans. However,...
Abstract Our integrated multi-omics analysis of paired primary and relapse DLBCL tumors provides comprehensive view to tumor evolution, drug resistance disease heterogeneity. is an aggressive systemic in which can arise virtually any part the body. Activated B-cell (ABC) germinal center (GCB)-like subtypes differ molecularly clinically. Three-year progression-free survival (PFS) ABC around 40% vs over 80% GCB. Whole genome (WGS, 7 patients), transcriptome (total RNA, patients) methylome...
Abstract High-grade serous ovarian cancer (HGSOC) is the most common and difficult to treat subtype. HGSOC diagnosed typically at late stage when it has already metastasized many tissues in peritoneal cavity. In order gain understanding of evolution reasons for chemoresistance, patients’ sequencing clinical data were extensively analyzed. We studied 124 cancerous samples from 30 patients sequenced whole genomes multiple collected diagnosis (N=92), interval debulking surgery (N=17), relapse...
Abstract Crossover rate is mostly studied with domesticated or lab-reared populations and little known about its genetic variation in the wild. We underpinnings of crossover outbred wild nine- ( Pungitius pungitius ) three-spined Gasterosteus aculeatus sticklebacks. In both species, females exceeded that males as did also repeatability R Females =0.21–0.33, Males =0.026–0.11), implying individual differences females, but no less so males. However, species sexes additive variance heritability...
This study examines how self-directed learning readiness (SDLR) affects students' preferences for distance and adapting to the changing conditions during pandemic. Moreover, changes in attitudes toward after a forced period are discovered. We found evidence that SDLR may raise desire help students transition from contact learning.