A5043104103- Mass Spectrometry Techniques and Applications
- Analytical Chemistry and Chromatography
- Ion-surface interactions and analysis
- Advanced Chemical Sensor Technologies
- Contact Dermatitis and Allergies
- Skin and Cellular Biology Research
- Analytical chemistry methods development
- Metabolomics and Mass Spectrometry Studies
- Dermatology and Skin Diseases
- Electrohydrodynamics and Fluid Dynamics
- Nail Diseases and Treatments
- Advancements in Transdermal Drug Delivery
South College
2023
GlaxoSmithKline (United States)
2020-2021
University of North Carolina at Chapel Hill
2015-2017
Communities In Schools of Orange County
2015
Abstract In vitro assessment of topical (dermal) pharmacokinetics is a critical aspect the drug development process for semi‐solid products (e.g., solutions, foams, sprays, creams, gels, lotions, ointments), allowing informed selection new chemical entities, optimization prototype formulations during nonclinical stage, and determination bioequivalence generics. It can also serve as tool to further understand impact different excipients on delivery, product quality, formulation microstructure...
The design and operation of an inexpensive, miniature low-temperature plasma ion source is detailed. operated in a "flow-through" configuration, wherein the gaseous or aerosolized analyte, caffeine pyrolyzed ethyl cellulose, carrier gas used as gas. In this flow-through sensitivity for standard pyrolysis products cellulose maintained increased reproducibility increased. Changes relative intensity ions from aerosol produced by are observed mass spectrum when configuration. Experiments suggest...
Differential ion mobility spectrometry (DIMS) separates ions based on differences in their mobilities low and high electric fields. When coupled to mass spectrometric analyses, DIMS has the ability improve signal-to-background by eliminating isobaric isomeric compounds for analytes complex mixtures. separation power, often measured resolution peak capacity, can be improved through increasing fraction of helium nitrogen carrier gas. However, because is higher helium, a greater number collide...
Differential ion mobility spectrometry (DIMS) separations are described using similar terminology to liquid chromatography, capillary electrophoresis, and drift tube spectrometry. The characterization comparison of all these typically explained in terms resolving power, resolution, and/or peak capacity. A major difference between is that DIMS space whereas the others time. However, time can, theory, be extended infinitely, space, such as separations, constrained by physical dimensions...
Differential ion mobility spectrometry (DIMS) devices separate ions on the basis of differences in low and high electric fields, can be used as a stand-alone analytical method or separation step before further analysis. As with other techniques, ability DIMS separations to retain structural characteristics analytes has been concern. For separations, this potential loss structure originates from fact that occur at atmospheric pressure ions, during their transit through device, undergo...