Abstract Sucralfate enemas present good results in the treatment of colitis, however mechanism action drug is not yet fully clarified. Objective To evaluate anti-inflammatory and antioxidant effects sucralfate diversion colitis model. Method Thirty-six Wistar rats underwent intestinal bypass by end colostomy descending colon distal mucous fistula. The animals were divided into 3 experimental groups according to daily dose received containing 0.9% SF, or 1 g/kg/day 2 g/kg/day. Each group was...

In addition to the presence of neoplasia in colon and rectum, patients with familial adenomatous polyposis (FAP) may develop numerous polyps carcinoma within upper gastrointestinal tract.The aim present paper was review incidence advanced duodenal or cancer their surgical outcomes. A retrospective patients' records from our department performed. Information retrieved a prospective collected data, including clinical (gender, age, family history), endoscopic [association colorectal (CRC),...

Aim: To investigate the relationship between beta-catenin and E-cadherin tissue quantitative expression (content) in tumors clinical prognostic factors patients with left colon cancer. Material Methods: Twenty nine adenocarcinoma located distal to splenic flexure were studied. Diagnosis histological variables related prognosis evaluated using hematoxylin-eosin. Beta-catenin analysed by immunohistochemistry specific anti-beta-catenin anti-E-cadherin monoclonal antibodies. Tissue was...

MTUYH and OGG1 genes have importance in the base excision repair systems of oxidized DNA bases. Modification tissue expression these is related to increased risk developing colorectal cancer.To evaluate MUTYH comparing normal neoplastic tissues patients with sporadic cancer correlate it clinical histopathological variables.MUTYH was quantified by RT-PCR values were compared tissues. measured normalized constitutive 18S gene. The level both correlated variables: age, gender, tumor location,...

To evaluate the effects of infliximab on inflammation colonic mucosa devoid from fecal stream.Twenty-four rats were submitted to a Hartmann's procedure. They remained for 12 weeks with derivation development diversion colitis excluded colorectal stump. After this period, they divided into 3 groups: one group received intervention saline (2.0 mL / week), other at doses 5 mg/kg/week and 10 five consecutively weeks. Concluded animals euthanized remove colon segments without stream. Colitis was...

Proliferating trichilemmal cysts (PTCs) are rare benign neoplasms originating from the follicular isthmus. They can undergo keratinization and malignant degeneration to form epidermoid carcinoma. occur on scalp in more than 90% of patients common elderly women. A 56-year-old woman complained perianal discomfort upon sitting. She presented with a nodule approximately 3 cm diameter that had exhibited slow progressive growth over 8 years. After surgical excision lesion safety margins,...

To evaluate the inflammatory intensity and measure tissue content of proteins claudin-3 occludin in colonic mucosa without fecal stream submit to intervention with curcumin.Thirty-six rats were submitted a proximal colostomy distal mucous fistula divided into two groups according sacrifice be performed or four weeks. Each group was three subgroups daily application enemas containing saline, curcumin at 50 mg/kg/day 200 mg/kg/day. Colitis diagnosed by histological analysis. Claudin-3...

Perianal Paget's disease (PPD) is a rare intraepithelial adenocarcinoma of the anal margin. Primary PPD likely represents intra-epithelial neoplasm from an apocrine source, whereas secondary may represent "pagetoid" spread anorectal malignancy. Histologic CDX-2 and CK20 are hallmark markers for colorectal-derived cells. Interestingly, our primary patient presented both positive no internal malignancy was identified. In addition, negative CK7 marker observed in case contrast with previously...

Abstract Purpose To verify if the application of enemas containing oily extracts curcumin preserves tissue content mucins in glands colonic mucosa without fecal stream. Method Thirty-six Wistar rats were submitted to diversion stream by proximal colostomy and distal mucous fistula. The animals subdivided into three groups, accordingly received with saline extract at concentrations 50 mg/kg/day or 200 mg/kg/day. After two four weeks intervention, irrigated colic segments removed. Neutral...

To evaluate the effects of sucralfate enemas in tissue contents E-cadherin and ?-catenin an experimental diversion colitis.Thirty-six male Wistar rats were submitted to a proximal colostomy distal mucous fistula. They allocated into three groups: first group received daily saline (2 mL/day) two other groups with at dosage 1 or 2 g/kg/day, respectively. Six animals each euthanized after weeks six four weeks. The inflammation excluded mucosa was evaluated by histological analysis. oxidative...

To evaluate the tissue content of neutral and acidic mucins, sulfomucins sialomucins in colonic glands devoid intestinal transit after enemas containing sucralfate n-acetylcysteine alone or combination.Sixty-four rats underwent bypass. A segment was collected to compose white group (without intervention). After derivation, animals were divided into two groups according whether performed daily for four weeks. Each subdivided subgroups substance used: control group: saline 0.9%; (SCF): SCF 2...

Colorectal cancer (CRC) is the most common malignancy of gastrointestinal tract and third type worldwide. The COVID-19 pandemic, during years 2020 2022, increased difficulties in offering adequate early diagnosis treatment to CRC patients During this period, it was only possible treat who evolved with complications, mainly intestinal obstruction perforation.

Purpose: To evaluate the inflammatory reaction and measure content of mucins, in colonic mucosa without fecal stream submit to intervention with mesalazine. Methods: Twenty-four rats were submitted a left colostomy distal mucous fistula divided into two groups according euthanasia be performed or four weeks. Each group was subgroups daily application enemas containing saline mesalazine at 1.0 g/kg/day. Colitis diagnosed by histological analysis validated score. Acidic mucins neutral...

Apresentação do Caso Relatamos o caso de uma paciente sexo feminino, 59 anos, assintomática, em acompanhamento com a Oncologia por neoplasia mama, que foi encaminhada para Coloproctologia devido formação cística pré-sacral detectada tomografia pelve. Solicitou-se colonoscopia, não identificou alterações, e ressonância magnética pelve evidenciou aspecto cístico no espaço posterior ao reto que, media 3,3x4,5x2,2 cm, conteúdo hemático proteico sugestivo hamartoma retrorretal, um PET scan...

Introdução Estudos experimentais mostraram que existe redução do conteúdo tecidual de mucinas ácidas (MA), neutras (MN), sulfomucinas e sialomucinas na mucosa cólica exclusa trânsito fecal desenvolve colite desuso (CD). Demonstrou-se a aplicação enemas contendo sucralfato (SCF) n-acetilcisteína (NAC) isolados no cólon excluso são eficazes para o tratamento da CD, pois têm capacidade adesão em tecidos inflamados associada aos efeitos antioxidantes cicatrizantes. Contudo, ainda não se...

Introdução A colite de derivação fecal (CDF) é um processo inflamatório assintomático que ocorre no segmento colorretal desfuncionalizado após cirurgias desvio do trânsito intestinal, como a colostomia ou ileostomia. Entretanto, cerca 30% dos pacientes podem apresentar forma sintomática da CDF, com evacuação mucossanguinolenta, tenesmo e desconforto abdominal. reconstituição o tratamento mais eficaz para mas entre 40% não têm esta reconstituição, desenvolve enfermidade. Para maioria,...

Relato do Caso Uma mulher de 18 anos, com histórico familiar suspeito para síndrome Peutz- Jeghers (SPJ), procurou o serviço queixa epigastralgia associada a vômitos pós-prandiais associados, por sua vez, quadros intermitentes sangramento digestivo baixo. Ao exame físico, apresentava melanose cutânea na região periférica dos lábios. A EDA mostrou lesão pediculada, lobulada, vinhosa no corpo gástrico e grande curvatura, cerca 7 cm em seu maior eixo, pedículo largo, que foi ressecada sem...

Relato do Caso Um homem de 84 anos, com antecedentes 3 infartos agudo miocárdio havia 1 ano, diabético e hipertenso, procurou o PS queixando-se parada eliminação gases fezes 10 dias, associada a vômitos. No exame físico, identificou-se abdome distendido, timpanismo ruídos hidroaéreos timbre metálico. Ao toque retal, não se identificava presença ou tumor tocável. O paciente foi submetido TC pelve, que identificou acentuada distensão todo cólon, pouca nas alças intestino delgado. mostrou ainda...

Relatamos o caso de uma paciente do sexo feminino, 67 anos, que referia hematoquezia, tenesmo, incontinência fecal e perda ponderal 10% peso havia 6 meses. A negava febre. O exame físico geral não apresentava alterações no proctológico notava-se lesão vegetante, friável, amolecida, se exteriorizava pelo canal anal à manobra Valsalva, com início a cerca 1 cm da borda anal, transponível, sendo possível tocar sua proximal. trazia colonoscopia mostrava vegetante reto distal, estendia por 5...

Introdução O tratamento para a doença hemorroidária (DH), afecção anorretal frequente devido ao aumento do fluxo sanguíneo e deslocamento distal dos coxins hemorroidários, contempla desde uma suplementação de fibras na dieta da ingestão água até diferentes opções cirúrgicas, como hemorroidectomia. Entretanto, escleroterapia (ET) ligadura elástica (LE) são os procedimentos mais comuns o das hemorroidas graus I III. Estudos recentes têm demonstrado que com espuma polidocanol (EEP) 3% eficácia...

Apresentação do Caso Um homem de 64 anos, ex-etilista e tabagista, queixava-se dor abdominal difusa havia 1 ano, não associada à alimentação, negava perda peso. Ele apresentava episódios eventuais diarreia acompanhada muco hematoquezia, os exames físico proctológico eram normais. O paciente tinha histórico familiar polipose ao gene MUTYH, que acometera dois três irmãos. Realizou-se colonoscopia ambulatorial, mostrou múltiplos pólipos lesões crescimento lateral espalhados por todo o cólon, em...