A5019922034- Inflammatory Biomarkers in Disease Prognosis
- Hemoglobinopathies and Related Disorders
- Cervical Cancer and HPV Research
- Ovarian cancer diagnosis and treatment
- Iron Metabolism and Disorders
- Selenium in Biological Systems
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Pregnancy and Medication Impact
- Birth, Development, and Health
- Trace Elements in Health
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- HIV/AIDS Research and Interventions
- Blood groups and transfusion
- Pharmacological Effects and Toxicity Studies
- Intraperitoneal and Appendiceal Malignancies
- HIV-related health complications and treatments
- Reproductive System and Pregnancy
- Global Cancer Incidence and Screening
- Maternal and fetal healthcare
- Blood properties and coagulation
- COVID-19 epidemiological studies
- Animal Disease Management and Epidemiology
Lagos University Teaching Hospital
2019-2024
University of Lagos
2015-2023
University of the Witwatersrand
2021
Fogarty International Center
2019
Babcock University
2014-2015
Aim . To determine the prevalence of sleep disturbance and its associated characteristics in HIV-positive outpatients on HAART using PSQI. Methods Using a cross-sectional design, 300 patients attending outpatient HIV/AIDS clinic at Lagos State University Teaching Hospital were recruited. Baseline data obtained included participants’ demographic data, educational qualification, marital status. Their treatment history, including duration since HIV diagnosis, most recent CD4 cell count, current...
The Mean platelet volume and counts are indicators of thrombotic potentials, risk factors for microvascular complications in diabetics. This study aimed to establish variations mean type 2 diabetic patients on treatment non-diabetic controls.This was an unmatched case-control involving 200 participants consisting 100 diabetics controls. Four half milliliters blood collected from non controls into EDTA anticoagulant tubes. Full count performed using the Sysmex KN-21N, (manufactured by...
Early evidence suggested that the impact of COVID-19 pandemic was less severe in Africa compared to other parts world. However, more recent studies indicate higher SARS-CoV-2 infection and mortality rates on continent than previously documented. Research is needed better understand immunity Africa.
Background: High red blood cell distribution width (RDW) is related to impairment of erythropoiesis, reflecting chronic inflammation and increased levels oxidative stress, both which are telltale signs type 2 diabetics. The aim this study was evaluate the relationship between RDW fasting sugar/blood pressure, compare results from diabetics with nondiabetic controls. Methods: This an unmatched case-control involving 200 participants consisting 100 Blood (4.5 mL) collected all controls, placed...
To improve the overall survival of epithelial ovarian cancer (EOC) patients, a more precise risk identification after completion standard treatment will enhance patients' follow-up surveillance and use individualized targeted therapy.
Purpose: This study investigated the prognostic performance of systemic immune-inflammation index (SII) in patients with epithelial ovarian cancer (EOC) Lagos, Nigeria. Methods: We performed a secondary analysis data 91 women who had treatment for EOC between 2009 and 2018. The associations pretreatment SII survivals were tested. Results: Pretreatment more than 610.2 was significant independent predictor reduced progression-free survival (HR = 2.68; 95% CI, 1.17 to 6.09) while greater 649.0...
Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group non-Hodgkin (NHLs) T- and B-cell origin where skin primary organ involvement. This a case 60-year-old Nigerian woman, who was diagnosed managed chronic dermatitis but further investigations confirmed diagnosis MF; she thereafter with topical glucocorticoids/chemotherapy improved on these treatments....
Background . This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia. Methods. A case-control, cross-sectional was conducted amongst patients attending clinic Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done were subjected electrocardiography (ECG). The descriptive data given as means ± standard deviation (SD). differences considered be statistically...
Background: There is still conflicting evidence on the extent to which maternal hyperhomocysteinemia a risk factor for pregnancy complications. Aims: The study aimed investigate impact of elevated homocysteine concentrations adverse outcomes among Nigerian women in Lagos. Materials and Methods: This was prospective cohort conducted at Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria. Participants were enrolled during first trimester following relevant data obtained by interview....
Background Inflammation is pathognomonic of all stages tumor formation, and therefore, there renewed interest in systemic inflammatory response (SIR) markers including haematological such as neutrophil-to-lymphocyte ratio (NLR) prognostic predictors several cancers. Aim This study was aimed to investigate the effect pretreatment peripheral blood NLR on survival prognosis patients with epithelial ovarian cancer (EOC). Methods We identified 93 a complete clinical record from cohort 155 who...
We assessed the impact of mHealth on Pap test screening uptake and also determined factors that affect among women in Lagos, Nigeria.A randomized controlled trial was carried out two tertiary health institutions Nigeria, between July 2020 March 2021. Participants were randomly assigned to either a text message (mHealth) intervention or usual care arm. The main study outcome smear testing within 6 months enrollment study. tested associations groups continuous variables using unpooled...
Many adolescents with sickle cell disease (SCD) have adjustment difficulties in the transition period from paediatric care to adult system because they find themselves unfamiliar waters where learn manage themselves. The aim of this study is evaluate prevalent crises and morbidities associated SCD Babcock University Teaching Hospital (BUTH), also assess level knowledge these about determine their emotional response disease.This was a retrospective review case notes anaemia that were seen...
Background . Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim this study was to investigate the impact HIV infection and zidovudine on red blood cells (RBC) parameters urine methylmalonic acid (UMMA) levels in patients with Material Methods A cross-sectional involving 114 subjects, 94 which are HIV-infected nonanaemic 20 negative subjects (Cg) as control. Full count level each subject were determined. Associations determined by Chi-square test...
We assessed the predictors of Pap smear testing uptake within 6 months after cervical cancer prevention education among women in Lagos, Nigeria. This was a prospective follow-up study conducted as part 'mHealth-Cervix trial' two teaching hospitals Nigeria, between August 2020 and April 2021. Participants were followed up for pre-enrolment education. The potential socio-demographic clinical during 6-month tested using predictive model binary logistic regression analysis. Statistical...
Abstract Background: Micronutrient deficiencies are common during pregnancy, especially in pregnant women from economically disadvantaged settings where diets with low content of minerals and vitamins consumed. Selenium is a non-metallic chemical element great importance to human health. This study will assess the effect selenium supplementation on major pregnancy outcomes disease progression among HIV-infected Lagos, Nigeria. Methods: A randomized, double-blind, placebo-controlled trial...
This study was aimed at investigating the prognostic impact of pretreatment thrombocytosis in epithelial ovarian cancer (EOC) patients Lagos, Nigeria.This a retrospective cohort involving review clinical record 72 with histologically confirmed EOC who were managed Lagos University Teaching Hospital, Nigeria over 7-year period from January 2010 to December 2016. Information on sociodemographic data and platelet counts diagnosis retrieved patients' medical records. Descriptive statistics then...
Background: There is a significant association of human T-lymphotropic viruses (HTLV) with lymphoid malignancies. HTLV causes lymphoproliferative malignancy CD4-activated cells called adult T-cell leukemia/lymphoma (ATL) and chronic myelopathy tropical spastic paraparesis/HTLV-1-associated (TSP/HAM). This study aims to determine the prevalence among patients malignancies at tertiary center in Lagos. Methods: A cross-sectional was carried out hematology clinic Lagos State University Teaching...
The link between plasma D-dimer levels and underlying malignancy has been established. How this translates in clinical practice as a marker of detection prognosis cervical cancer (CC) is still unknown. This study compared the women with without CC assessed associations stage grade CC. It was comparative cross-sectional 65 histological diagnosis an equal number age-matched cancer-free enrolled at University Teaching Hospital Lagos, Nigeria. Participants' sociodemographic data well venous...
Background Selenium is an essential micronutrient that plays a crucial role in wide range of physiological processes, including immune responses. deficiency has been recognized as associated factor the progression HIV to advanced disease and/or mortality. Although selenium supplementation shown reduce hospitalizations and improve cellular immunity, evidence remains mixed. This study aimed determine prevalence its relationship with markers HIV-infected children at Lagos University Teaching...
The occurrence of a myeloproliferative disorder in association with an aggressive lymphoproliferative is distinctly unusual phenomenon. We report case concurrent leukaemia-lymphoma syndrome characterized by BCR/ABL-negative disease, eosinophilia and lymphoma. bone marrow chromosome analysis showed the karyotype 46, XY, t(8;9) (q12; p33), which indicated presence FGFR1 gene translocations. 8p12 (EMS) / stem cell (SCLL) belongs to tyrosine kinase fusion genes chronic diseases. patient was...