Introduction: timely PEP after needle stick exposure to high risk body fluids can reduce the rate of occupational transmission significantly. Ignorance this may increase seroconversion HIV for healthcare workers. This study was conducted with aim demonstrating current level knowledge and practise workers as regards PEP.

Background: High red blood cell distribution width (RDW) is related to impairment of erythropoiesis, reflecting chronic inflammation and increased levels oxidative stress, both which are telltale signs type 2 diabetics. The aim this study was evaluate the relationship between RDW fasting sugar/blood pressure, compare results from diabetics with nondiabetic controls. Methods: This an unmatched case-control involving 200 participants consisting 100 Blood (4.5 mL) collected all controls, placed...

Background: Sickle cell anaemia is an autosomal recessive disorder which occurs as a result of the substitution glutamic acid with valine at 6th position haemoglobin beta chain, resulting in synthesis abnormal and consequent production characteristic sickled red blood cells. homozygous form where two HbS genes are inherited, whilst disease, inherited along another eg HbE, HbC, etc. Aims Objectives: This study was aimed assessing awareness knowledge sickle disease among students tertiary...

Introduction: Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres Nigeria, there is no routine pre-transfusion screening for HTLV. The study aims determine the prevalence HTLV-1 HTLV-2 among healthy donors at a tertiary centre Lagos.

Background. Priapism is a pathological condition of penile erection that persists beyond, or unrelated to, sexual stimulation. Impotence and infertility are major problems in male sickle cell disease patients, priapism has been implicated as cause impotence infertility. The aim this study to determine prevalence assess the knowledge homozygous patients about it Lagos, Nigeria. Methods. A cross-sectional was conducted amongst Lagos State University Teaching Hospital. Pretested questionnaires...

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group non-Hodgkin (NHLs) T- and B-cell origin where skin primary organ involvement. This a case 60-year-old Nigerian woman, who was diagnosed managed chronic dermatitis but further investigations confirmed diagnosis MF; she thereafter with topical glucocorticoids/chemotherapy improved on these treatments....

Background . This study sought to identify the pattern of electrocardiographic changes in steady state adult sickle cell anaemia. Methods. A case-control, cross-sectional was conducted amongst patients attending clinic Lagos State University Teaching Hospital, Ikeja, and HbAA controls. All consenting participants had haemoglobin electrophoresis done were subjected electrocardiography (ECG). The descriptive data given as means ± standard deviation (SD). differences considered be statistically...

Purpose: Hypercoagulability in sickle cell anemia (SCA) may be responsible for the increased development of vascular occlusion certain organs as well acute pain episodes. The causes hypercoagulability SCA are multifactorial and include raised homocysteine levels. This study, therefore, aimed to determine serum levels patients steady state correlate its with disease severity. Patients Methods: was a cross-sectional study done among attending Haematology Clinic Lagos State University Teaching...

Background: Patients with sickle cell disease have an amplified vulnerability to urinary tract infection, because of abnormally dilute and alkaline urine, which favors bacterial proliferation. This is due altered blood flow in the renal vasculature, causes papillary necrosis loss concentrating acidifying ability nephrons. Asymptomatic bacteriuria common, but prevalence populations varies widely age, gender, sexual activity presence genitourinary abnormalities. The aim this study was...

Immunity in pregnancy is physiologically compromised, and this may affect CD4 count levels. It well-established that several factors level pregnancy. This study aimed to determine the mean reference range of human immunodeficiency virus (HIV)-positive pregnant women Lagos, Nigeria.A retrospective was carried out at antenatal clinics Maternal Child Center a secondary health center Lagos State, Nigeria. Records HIV-positive various gestational ages, including CD4+ cell booking, packed volume...

Background . Anaemia is a common complication of human immunodeficiency virus (HIV) infection. The aim this study was to investigate the impact HIV infection and zidovudine on red blood cells (RBC) parameters urine methylmalonic acid (UMMA) levels in patients with Material Methods A cross-sectional involving 114 subjects, 94 which are HIV-infected nonanaemic 20 negative subjects (Cg) as control. Full count level each subject were determined. Associations determined by Chi-square test...

In occult hepatitis B virus (HBV) infection, the HBV DNA is present in blood or liver tissue patients negative for surface antigen (HBsAg) with without anti-HBV antibodies. Thus, absence of HBsAg only reduces risk transmission and not sufficient enough to ensure infection.This study was aimed at determining prevalence infection among donors Lagos.A cross-sectional done 101 consenting Lagos State University Teaching Hospital, Ikeja, between November 2016 January 2017.HBV analysis viral load...

Background: There is a significant association of human T-lymphotropic viruses (HTLV) with lymphoid malignancies. HTLV causes lymphoproliferative malignancy CD4-activated cells called adult T-cell leukemia/lymphoma (ATL) and chronic myelopathy tropical spastic paraparesis/HTLV-1-associated (TSP/HAM). This study aims to determine the prevalence among patients malignancies at tertiary center in Lagos. Methods: A cross-sectional was carried out hematology clinic Lagos State University Teaching...

Introduction: Sickle cell anaemia (SCA) is an inherited abnormality of haemoglobin associated with reduced life expectancy. Patients' complications include dyslipideamia. This study was aimed at determining the artherogenic index plasma (AIP) in sickle patients and compares value to HbAA controls value. A high AIP strongly predictive elevated cardiovascular risk.

The significant causes of mortality among individuals with sickle cell anaemia (SCA) such as acute chest syndrome and cerebrovascular disease are related to vascular occlusion. Polymorphisms the methylene tetrahydrofolate reductase (MTHFR) gene in persons have been suggested a potential risk for vaso-occlusive events, C677T A1298C polymorphisms being commonest. This study therefore aimed establish pattern MTHFR mutations adults HbSS phenotype attending Haematology Clinic Lagos State...

BACKGROUND: Prolonged use of pentazocine in sickle cell disease (SCD) because chronic pain may result mental dependence (addiction) and/or physical leading to withdrawal symptoms on suddenly stopping its use. This study was aimed at determining the prevalence addiction among SCD patients and health-care worker (HCW) perception use.MATERIALS AND METHODS: an interviewer-administered, questionnaire-based, cross-sectional study. The involved clients attending Lagos State University Teaching...

Background Metabolic syndrome (MetS), a clinical condition characterized by insulin resistance, glucose intolerance, dyslipidemia, hypertension, and obesity, has been linked with raised levels of serum ferritin (Sfr) concentrations. Objectives This study was carried out to compare hemoglobin (Hb) Sfr concentrations in patients MetS, regular donors first-time donors. Materials Methods A total 102 subjects who were between 18 60 years enrolled for the study. They divided into three groups. The...

Priapism is one of the diverse complications sickle cell disease (SCD). SCD many causes priapism. Ischaemic and stuttering priapisms are types seen in SCD. Apart from pain psychological trauma associated with ischaemic priapism, erectile dysfunction impotence most severe priapism that may require use penile prosthesis patients. The outcome time-dependent dependent on type management administered. This review highlights, anatomy penis, physiology normal erection, focusing pathophysiology so...

Background: The choice of high-performance liquid chromatography (HPLC) to measure HbF and HbA2in sickle cell disease patients is regarded as a method by many researchers. This study was aimed at using HPLC in determining the mean gender-specific reference values anemia (SCA) population bringing fore all associated implications. Materials Methods: cross-sectional, retrospective, descriptive involving SCA patients. All case notes containing hemoglobin quantification reports were reviewed...

Systemic lupus erythematosus (SLE) and sickle cell disease (SCD) are distinct multisystemic diseases that commonly affect blacks. There few reports of their co-existence in Western literature a paucity Sub-Saharan Africa. Their is associated with diagnostic delay treatment dilemmas. The aim to describe the clinical, laboratory, profile Nigerian disease. A 7-year retrospective descriptive study patients was performed. Medical records eligible were extracted into proforma, transferred SPSS,...

The Kikuchi-Fujimoto is a rare, self-limiting disease, which characterized by regional lymphadenopathy. It occurs worldwide with higher prevalence among Asians and women below the age of forty years. We present 41-year-old Nigerian woman who was investigated extensively for unilateral left cervical She eventually diagnosed as having disease managed conservatively thereafter. describe case report review literature better awareness amongst medical practitioners pathologists in Africa.

Multiple myeloma (MM) is a plasma cell disorder associated with clonal proliferation of cells. Nonsecretory multiple (NSMM) rare variant MM and accounts for approximately 1% to 5% all cases. It defined as symptomatic without detectable monoclonal immunoglobulin on serum or urine electrophoresis. This usually poses diagnostic challenge the clinician. We present 60-year-old Nigerian man who was investigated extensively bone pain, weight loss, anaemia. He eventually diagnosed having...

INTRODUCTION: Sickle cell anemia is associated with intense oxidative stress, and optimal antioxidant levels are essential to prevent continuous oxidant tissue damage. The role of damage red blood cells in sickle (SCA) has been interest recent years, some available results indicate that sickled produce almost twice as much superoxide, hydrogen peroxide, hydroxyl free radicals compared normal cells. To counter the effects oxidants, have evolved a number self-sustaining activities defense...