A5026543283- Parkinson's Disease Mechanisms and Treatments
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Neurological disorders and treatments
- Dysphagia Assessment and Management
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
- Restless Legs Syndrome Research
- Neurological diseases and metabolism
- Animal Disease Management and Epidemiology
- Genomics and Rare Diseases
- Voice and Speech Disorders
- T-cell and Retrovirus Studies
- Vector-Borne Animal Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Lymphoma Diagnosis and Treatment
- HIV-related health complications and treatments
- Cancer Research and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Neurogenetic and Muscular Disorders Research
- Autoimmune Bullous Skin Diseases
- Epilepsy research and treatment
- Lymphadenopathy Diagnosis and Analysis
- Oral and gingival health research
- Studies on Chitinases and Chitosanases
University College London
2020-2025
National Hospital for Neurology and Neurosurgery
2021-2023
King's College London
2021
Osaka City University
2019
Osaka University
2019
National Hospital of Sri Lanka
2019
University of Port Harcourt
2014
Rivers State University
2014
University of Port Harcourt Teaching Hospital
2013-2014
Parkinson's disease (PD) has the fastest rising prevalence of all neurodegenerative diseases worldwide. However, it is unclear whether its incidence increased after accounting for age and changes in diagnostic patterns same population. We conducted a cohort study individuals aged ≥50 years within large UK primary care database between January 2006 December 2016. To account possible patterns, we calculated PD using four case definitions with different stringency derived from combination...
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...
Background: High red blood cell distribution width (RDW) is related to impairment of erythropoiesis, reflecting chronic inflammation and increased levels oxidative stress, both which are telltale signs type 2 diabetics. The aim this study was evaluate the relationship between RDW fasting sugar/blood pressure, compare results from diabetics with nondiabetic controls. Methods: This an unmatched case-control involving 200 participants consisting 100 Blood (4.5 mL) collected all controls, placed...
ABSTRACT Background Parkinson's disease (PD) is associated with increased mortality, but little known about changes over time, and relationship to progression. Objectives To explore how PD mortality rates have changed time their duration demographics using a large population‐based cohort in the UK. Methods We included individuals aged 50+ years first recording of diagnosis at least two prescriptions any antiparkinsonian drug actively registered within general practice from 2006 2016 up six...
Introduction: Transmission of human T-lymphotropic viruses (HTLV) occurs from mother to child, by sexual contact and blood transfusion. Presently, in most centres Nigeria, there is no routine pre-transfusion screening for HTLV. The study aims determine the prevalence HTLV-1 HTLV-2 among healthy donors at a tertiary centre Lagos.
Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group non-Hodgkin (NHLs) T- and B-cell origin where skin primary organ involvement. This a case 60-year-old Nigerian woman, who was diagnosed managed chronic dermatitis but further investigations confirmed diagnosis MF; she thereafter with topical glucocorticoids/chemotherapy improved on these treatments....
Hospitalization in Parkinson's disease (PD) is associated with reduced quality of life, caregiver burden and high costs. However, no large-scale studies rate causes hospitalizations patients PD have been published.To investigate the reasons for hospitalization factors among people compared to general population.We examined admission matched controls The Health Improvement Network from 2006 2016. Multivariable Poisson regression was used explore effects age, gender, social deprivation,...
We determined the prevalence, incidence, and risk factors for epilepsy in Nigeria.We conducted a door-to-door survey to identify cases of 3 regions. estimated age-standardized prevalence adjusted nonresponse sensitivity 1-year retrospective incidence active epilepsy. To assess potential factors, we case-control study by collecting sociodemographic factor data. odds ratios using logistic regression analysis corresponding population attributable fractions (PAFs).We screened 42,427 persons (age...
Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association polymorphic variability self-declared cognition 1100 Nigerians with PD 1097 age-matched healthy controls. Cognition was assessed using single item question (item 1.1) of MDS-UPDRS. genotype allele frequencies did differ controls ( p > 0.05). No allelic or genotypic observed age at onset PD. In PD, ε 4/ 4 conferred a two-fold...
Background: There is a significant association of human T-lymphotropic viruses (HTLV) with lymphoid malignancies. HTLV causes lymphoproliferative malignancy CD4-activated cells called adult T-cell leukemia/lymphoma (ATL) and chronic myelopathy tropical spastic paraparesis/HTLV-1-associated (TSP/HAM). This study aims to determine the prevalence among patients malignancies at tertiary center in Lagos. Methods: A cross-sectional was carried out hematology clinic Lagos State University Teaching...
Abstract Human genetics research lacks diversity; over 80% of genome-wide association studies (GWAS) have been conducted on individuals European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation personalized medicine. This systematic review provides an overview involving Parkinson’s (PD) in under-represented populations (URP), and sets a baseline measure the future impact current...
The Kikuchi-Fujimoto is a rare, self-limiting disease, which characterized by regional lymphadenopathy. It occurs worldwide with higher prevalence among Asians and women below the age of forty years. We present 41-year-old Nigerian woman who was investigated extensively for unilateral left cervical She eventually diagnosed as having disease managed conservatively thereafter. describe case report review literature better awareness amongst medical practitioners pathologists in Africa.
Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association polymorphic variability cognition 1100 Nigerians with PD 1097 matched healthy controls. Cognition was assessed using single item question (item 1.1) of MDS-UPDRS. genotype allele frequencies did differ controls (p > 0.05). No allelic or genotypic observed age at onset PD. In PD, ε 4/ 4 conferred a two-fold risk cognitive...