A5088316746- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Parkinson's Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- HIV Research and Treatment
- Neurological disorders and treatments
- Epilepsy research and treatment
- HIV-related health complications and treatments
- RNA regulation and disease
- Diphtheria, Corynebacterium, and Tetanus
- Intracerebral and Subarachnoid Hemorrhage Research
- Nuclear Receptors and Signaling
- HIV/AIDS Research and Interventions
- Esophageal and GI Pathology
- Folate and B Vitamins Research
- Migraine and Headache Studies
- Dysphagia Assessment and Management
- Myasthenia Gravis and Thymoma
- Mitochondrial Function and Pathology
- Pharmacological Effects and Toxicity Studies
- Herpesvirus Infections and Treatments
- Sepsis Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Renal and Vascular Pathologies
- Botulinum Toxin and Related Neurological Disorders
University of Lagos
2013-2025
Lagos University Teaching Hospital
2005-2024
Olabisi Onabanjo University Teaching Hospital
2005
North Tyneside General Hospital
2005
University College London
2005
Stroke is a significant economic, social, and medical problem worldwide. This retrospective follow-up study aimed to review the pattern, types, case fatality of stroke in Nigeria.Records all patients admitted into Ogun State University Teaching Hospital (OSUTH), Sagamu, from December 1993 November 2003 were reviewed. Patients classified hemorrhage or infarct using World Health Organization criteria. Information was obtained as time death those who died at 24 hours, 7 days, 30 6 months...
We investigated the 1-year prevalence, clinical features and mode of treatment headache in medical students University Lagos, Nigeria, using a self-administered questionnaire. Headache prevalence was 46.0% significantly higher women than men (62.8% vs. 34.1%). Prevalence tension-type that migraine (18.1% 6.4%). Although had similar both sexes (male 17.3%, female 19.2%), three times more common (10.9% 3.2%). A family history present 22.0%. Only 4.6% sought assistance, whereas 68.2% took...
<i>Background:</i> The burden of cerebrovascular disease in developing countries is projected to be on the rise. However, data current epidemiology stroke Africa are sparse. <i>Methods:</i> Using a 3-staged method, we conducted door-to-door study an urban, mixed-income community Lagos, Nigeria. We used modification WHO protocol first stage, stroke-specific questionnaire second stage and neurological examination all persons screening positive for third stage. also...
Objectives: To investigate the prevalence of post-stroke depression (PSD), its associated factors and impact on quality life (QoL) among outpatients in a Nigerian hospital.Methods: This cross-sectional study was carried out 140 adults made up 70 stroke survivors matched controls with stable hypertension. Participants were administered questionnaires to profile their socio-demographic clinical characteristics. Subsequently, they assessed modified mini-mental state examination (MMSE), Rankin...
Introduction. HIV-associated neurocognitive disorder (HAND) remains common despite the availability of antiretroviral therapy. Routine screening will improve early detections. Objective. To compare performance minimental state examination (MMSE) and international HIV dementia scale (IHDS) in assessing function HIV/AIDS patients on Methods. A case-control study 208 HIV-positive 121 HIV-negative individuals. Baseline demographic data were documented cognitive assessed using two instruments....
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...
Abstract Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for development of targeted therapies in global context. We conducted largest sequencing characterization potentially disease-causing, protein-altering and splicing mutations 710 cases 11,827 controls from genetically predicted African or admixed ancestries. explored copy number variants (CNVs) runs homozygosity (ROHs) prioritized early onset familial cases....
Objective: To determine the profile of neurological admissions at Lagos University Teaching Hospital Methods: Neurological admission Hospital, Lagos, Nigeria between 1995 and 1999 were reviewed using medical records. Result: accounted for 19.635 total admissions. Cerebrovascular diseases most common cause, accounting 11.65% admissions; followed by infection nervous system which made up 6.07%. Cerebral malaria, pyogenic meningitis tetanus infections All other constituted less than 2% On...
Records of 349 tetanus patients, aged 10 years and above, admitted to the Lagos University Teaching Hospital, Nigeria, between 1990 1999 were reviewed. The male:female ratio was 1.98:1, ages 88 years, with a mean age 29.8 years. overall case fatality rate (CFR) 36.96% (33.19% for men 44.44% women). CFR is similar that previously reported in hospital, but higher than from Europe North America. lowest 10-19-year group, there trend towards increasing age. Tetanus patients intensive care unit...
Background. Sensory neuropathy (SN) is one of the most common AIDS-associated neurologic disorders especially in era highly active antiretroviral therapy (HAART). The aim this study was to determine prevalence SN among highly-active-antiretroviral-therapy- (HAART-) experienced and HAART-naïve HIV-positive individuals investigate relationship demographic, clinical, laboratory factors. Methods. 323 patients with HIV infection (142 on HAART 181 naïve) were enrolled a cross-sectional screening...
Background: There is evidence of an association between mediators inflammation, particularly C-reactive protein (CRP), and outcome acute ischaemic stroke. This provides a potential opportunity for interventions aimed at improving outcome. sparse data exploring the role inflammatory markers such as CRP stroke in Africans. The study objective was to determine admission serum levels short-term Nigerian patient presenting with stroke.Materials Methods: Consecutive patients hospitalized...
Co-morbid depression and suicidal ideation in people with epilepsy (PWE) developing countries are under-recognised, so may be consequently undertreated. This study was designed to determine the frequency clinical correlates of interictal PWE.Using a prospective design, we evaluated 96 PWE two groups controls (103 age- sex-matched population 13 persons DSM - IV diagnosis major (controls CWD) without epilepsy. Depression assessed using Zung Self-rating scale (scores =40 indicating...
Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association polymorphic variability self-declared cognition 1100 Nigerians with PD 1097 age-matched healthy controls. Cognition was assessed using single item question (item 1.1) of MDS-UPDRS. genotype allele frequencies did differ controls ( p > 0.05). No allelic or genotypic observed age at onset PD. In PD, ε 4/ 4 conferred a two-fold...
Hypercholesterolaemia is a risk factor for cardiovascular diseases. Tocotrienols reportedly possess hypocholesterolaemic activity. This study examined the effect of tocotrienols (T3) in TOCOVIDTM Suprabio TM on serum lipids. Patients and Methods :A randomised (2:1), open-label patients with mild hypercholesterolaemia (= 5.18mmol/L to <7.77mmol/L) one additional was carried out. Subjects received either (as ) (n=28) or vitamin E (a-tocopherol) 500mg daily (n=16). Fasting lipids were compared...
Essential tremor (ET) is one of the commonest movement disorders though prevalence varies globally. There paucity data on ET in sub-Saharan Africa. The study aimed to determine a Nigerian community. This door-to-door survey was conducted two stages. In Stage 1, 3000 randomly selected residents an urban centre Lagos, Nigeria, were screened using questionnaire detect symptoms disorder. 234 participants who responded positively regarding presence tremors rescreened ET-specific questionnaire,...
Introduction: The risk of developing neurodegenerative disorders (NDDs) such as Alzheimer’s disease and related dementias (ADRD) Parkinson’s atypical parkinsonism (PDAP), has been alluded to arise predominantly from the interplay between environmental exposures genetic variability. contributions these factors NDD in Black sub-Saharan Africans are largely unknown. broad aim SERGEND is investigate effect specific variability on ADRD PDAP our population. Methods: SERGEND, a national,...
Background There is no information from a prospective study on the relationship between admission hyperglycaemia and stroke outcome in Nigerians. This was designed to determine impact of short-term (case fatality rate functional outcome) adult Nigerians with acute ischaemic stroke. Methods 100 consecutively attending first-ever ischemic patients our tertiary facility within 72 hours onset were recruited. Stroke severity NIHSS random blood glucose levels documented admission. The measures...