A5086247905- Muscle Physiology and Disorders
- RNA Research and Splicing
- Knee injuries and reconstruction techniques
- Silk-based biomaterials and applications
- RNA modifications and cancer
- Bone Metabolism and Diseases
- CRISPR and Genetic Engineering
- Bone health and treatments
- Tendon Structure and Treatment
- Cardiomyopathy and Myosin Studies
- RNA regulation and disease
- Angiogenesis and VEGF in Cancer
- Bone and Dental Protein Studies
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Genomic variations and chromosomal abnormalities
- Virus-based gene therapy research
- Periodontal Regeneration and Treatments
- Adipose Tissue and Metabolism
- Phytase and its Applications
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Ocular Oncology and Treatments
- Genomics and Rare Diseases
- Parkinson's Disease Mechanisms and Treatments
Gombe State University
2025
Harvard University
2004-2023
University of Padua
1992-2022
Boston Children's Hospital
2004-2019
Albert Einstein College of Medicine
2013-2016
West Virginia University
2013
Harvard University Press
2009
Université de Montréal
2006
Hôpital Notre-Dame
2006
University Health Network
2001
We report a novel technology for the rapid healing of large osseous and chondral defects, based upon genetic modification autologous skeletal muscle fat grafts.These tissues were selected because they not only possess mesenchymal progenitor cells scaffolding properties, but also can be biopsied, genetically modified returned to patient in single operative session.First generation adenovirus vector carrying cDNA encoding human bone morphogenetic protein-2 (Ad.BMP-2) was used gene transfer...
Abstract Tissue engineering approaches that harness the stimulatory power of platelet‐rich plasma have produced encouraging results in anterior cruciate ligament (ACL) repair. However, a number recent studies demonstrated age‐dependent differences cellular responses to such an approach. Identifying reasons for these would allow counteracting them and consequently improve outcomes. In this study we hypothesized age‐related effects are caused by expression receptors growth factors released...
Abstract Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for development of targeted therapies in global context. We conducted largest sequencing characterization potentially disease-causing, protein-altering and splicing mutations 710 cases 11,827 controls from genetically predicted African or admixed ancestries. explored copy number variants (CNVs) runs homozygosity (ROHs) prioritized early onset familial cases....
Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatological condition. Although it has been proposed that JIA an autoimmune component, autoantigens are still unknown. Using biochemical and proteomic approaches, we identified molecular chaperone transthyretin (TTR) as antigenic target for B T cell immune responses. TTR was eluted from IgG complexes affinity purified 3 patients, a statistically significant increase in autoantibodies observed group of 43 patients. Three...
Inadequate capillary growth in pressure-overload hypertrophy impairs myocardial perfusion and substrate delivery, contributing to progression failure.Capillary is tightly regulated by angiogenesis factors like vascular endothelial factor (VEGF) endogenous inhibitors such as the splice variant of VEGF receptor-1, sVEGFR-1.We hypothesized that inadequate expression up-regulation VEGFR-1 its soluble variant, sVEGFR-1, restrict hypertrophy. Methods resultsNeonatal New Zealand White rabbits...
Duchenne and Becker muscular dystrophies are allelic X-linked recessive neuromuscular diseases affecting both skeletal cardiac muscles. Therefore, owing to their single X chromosome, the affected boys receive pathogenic gene mutations from unknowing carrier mothers. Current pharmacological drugs palliative that address symptoms of disease rather than genetic cause imbedded in
Alzheimer and Parkinson diseases are associated with cholinergic neuron loss deterioration of bone mineral density. Gene therapy through either gene transfer, CRISPR editing, or modulation holds the potential to cure diseases. The emerging role weight-bearing exercise in prevention of, care for, osteoporosis, obesity, diabetes has been previously recognized. Moreover, endurance offers a viable alternative reduce amyloid peptides deposits while increasing density patients. β-amyloid peptides,...
Abstract Osteopontin is a noncollagenous, phosphorylated extracellular glycoprotein, expressed in mineralized and nonmineralized tissues, organs body fluids. The protein contains an RGD tripeptide cell‐binding motif, subjected to variety of posttranslational modifications that play important roles its multiple biological functions, such as bone remodeling inhibition pathological calcification. In this study, we have bovine osteopontin prokaryotic system identified the seven amino acid...
The incidence rates of Duchenne and Becker muscular dystrophies (X-linked recessive) in a given sample the Italian population were recalculated using results DNA dystrophin analysis. While rate dystrophy remained unchanged, new figure for (7.2 per 100,000 male live births) was much higher than previously reported, since molecular diagnosis revealed additional cryptic cases, but this is still an underestimate.
In human, germ line mutations in the tumor suppressor retinoblastoma (Rb) predispose individuals to retinoblastoma, whereas somatic inactivation of Rb contributes progression a large spectrum cancers. mice, is highly expressed restricted cell lineages including neurogenic, myogenic, and hematopoietic systems, disruption gene leads specific embryonic defects these tissues. The symmetry between expression mutant mice suggest that transcriptional control during embryogenesis pivotal for normal...