A5047715924- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Mitochondrial Function and Pathology
- Cancer Treatment and Pharmacology
- Orthopedic Surgery and Rehabilitation
- Cardiovascular Syncope and Autonomic Disorders
- Innovations in Medical Education
- Peripheral Nerve Disorders
- Hereditary Neurological Disorders
- Endoplasmic Reticulum Stress and Disease
- Mesenchymal stem cell research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Total Knee Arthroplasty Outcomes
- Shoulder Injury and Treatment
- Foot and Ankle Surgery
- Advanced Neuroimaging Techniques and Applications
- Nerve Injury and Rehabilitation
- Muscle Physiology and Disorders
- Autophagy in Disease and Therapy
- Myofascial pain diagnosis and treatment
- Neurological and metabolic disorders
- Clinical Reasoning and Diagnostic Skills
- Advances in Oncology and Radiotherapy
The University of Texas Health Science Center at Houston
2015-2025
Baylor College of Medicine
2012-2024
Mayo Clinic
2024
Northwestern University
2024
American Academy of Neurology
2024
Cornell University
2024
Neurology, Inc
2020
Texas Neurology
2019
The University of Texas at Austin
2014-2017
Harris Health System
2012-2017
Tetrabenazine is efficacious for chorea control; however, tolerability concerns exist. Deutetrabenazine, a novel molecule that reduces chorea, was well tolerated in double-blind, placebo-controlled study.To evaluate the safety and explore efficacy of conversion from tetrabenazine to deutetrabenazine patients with associated Huntington disease (HD).In this ongoing, open-label, single-arm study started on December 21, 2013, 37 at 13 Study Group sites United States Australia who were taking...
Huntington disease (HD) is a genetic neurodegenerative disorder. Given the focus on motor manifestations, nonmotor symptoms are frequently underappreciated in clinical evaluations, despite contributing to primary functional impairment. A diagnosis of motor-onset as definition manifest misrepresents complex nature HD presentation. Despite recent attempt integrate diagnostic criteria, practical guidelines necessary inform diagnosis. We propose an framework and staging system that prioritizes...
Rapid eye movement sleep behavior disorder (RBD) is a condition closely associated with Parkinson disease (PD). RBD disturbance that frequently manifests early in the development of PD, likely reflecting disruption normal functioning anatomical areas affected by neurodegenerative processes. Although specific neuropathological aspects shared and PD have yet to be fully documented, further characterization critical discovering reliable biomarkers predict onset. In current study, we tested...
Autophagy is an important homeostatic mechanism that eliminates long-lived proteins, protein aggregates and damaged organelles. Its dysregulation involved in many neurodegenerative disorders. therefore a promising target for blunting neurodegeneration. We searched novel autophagic pathways primary neurons identified the cytosolic sphingosine-1-phosphate (S1P) pathway as regulator of neuronal autophagy. S1P, bioactive lipid generated by sphingosine kinase 1 (SK1) cytoplasm, implicated cell...
Huntington disease (HD) is the most common inherited neurodegenerative disorder. It has no cure. The protein huntingtin causes HD, and mutations to it confer toxic functions that lead neurodegeneration. Thus, identifying modifiers of mutant huntingtin-mediated neurotoxicity might be a therapeutic strategy for HD. Sphingosine kinases 1 (SK1) 2 (SK2) synthesize sphingosine-1-phosphate (S1P), bioactive lipid messenger critically involved in many vital cellular processes, such as cell survival....
Abstract Elucidating the genetic contributions to Parkinson’s disease (PD) etiology across diverse ancestries is a critical priority for development of targeted therapies in global context. We conducted largest sequencing characterization potentially disease-causing, protein-altering and splicing mutations 710 cases 11,827 controls from genetically predicted African or admixed ancestries. explored copy number variants (CNVs) runs homozygosity (ROHs) prioritized early onset familial cases....
Huntington's disease (HD) is a neurodegenerative disorder caused by an abnormal CAG expansion in the Huntingtin (HTT) gene. Given its simple genetic cause but complex pathogenic mechanisms, interest targeting HTT for HD treatment growing, necessitating clear understanding of regulation. protein primarily exists core with HAP40, forming highly ordered structure two large globular domains connected bridge. We previously demonstrated that HAP40 conserved Drosophila, controls HTT's function,...
IntroductionSome patients with cervical dystonia (CD) receiving long-term botulinum neurotoxin (BoNT) therapy report early waning of treatment benefit before the typical 12-week reinjection interval.This phase 4, open-label, randomized, noninferiority study (CD Flex; NCT01486264) compared 2 incobotulinumtoxinA injection schedules (Short Flex: 8 ± weeks; Long 14 weeks) in CD patients. Previous BoNT-responsive subjects who reported acceptable clinical lasting < 10 weeks were recruited....
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Prediction of motor diagnosis in Huntington's disease (HD) can be improved by incorporating other phenotypic and biological clinical measures addition to cytosine-adenine-guanine (CAG) repeat length age.
This is the second in a series of articles related to concept "torsional" anatomy. The objective this article provide musculoskeletal ultrasound (MSKUS) anatomy forearm position hemispastic flexion as reference relevant needle procedures. Methods MSKUS images were obtained healthy human subject. Marker dots placed over common injection sites for spasticity. probe was centered each dot obtain cross-sectional view. A pair recorded site: first anatomic neutral and hemiparetic spastic position....
To prove the efficacy and safety of dextromethorphan/quinidine 20mg/10mg in patients with irritability due to HD.
Objectives To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position hemiparetic flexion as a reference for spasticity injections. After stroke, can result anatomic distortion hand. Spasticity may require treatment with botulinum toxin or phenol Anatomic decrease accuracy Standard references are limited utility because they not this spastic position. There presently is no literature these postures. This study part three series examining torsional body. Design...
Background: There is considerable debate regarding the use of intraoperative microelectrode recording (MER) in deep brain stimulation (DBS). Objective: To determine if MER impacts final position lead implant DBS subthalamic nucleus (STN) and globus pallidus (GPi) to evaluate incidence complications. Methods: The authors conducted a retrospective chart review all patients who underwent STN GPi with MER, at University Texas Health Science Center Houston from June 1, 2009 October 2013 compare...