A5087641052- Parkinson's Disease Mechanisms and Treatments
- Biomedical and Engineering Education
- Colorectal Cancer Treatments and Studies
- Biotechnology and Related Fields
- Genetic factors in colorectal cancer
- CRISPR and Genetic Engineering
- Nuclear Receptors and Signaling
- Genomic variations and chromosomal abnormalities
- Lysosomal Storage Disorders Research
- Genetics, Bioinformatics, and Biomedical Research
- RNA regulation and disease
- Genetic Associations and Epidemiology
- Neurological diseases and metabolism
- COVID-19 Clinical Research Studies
- Sleep and related disorders
- Genetic Neurodegenerative Diseases
- Optical properties and cooling technologies in crystalline materials
- Multiple Myeloma Research and Treatments
- Genomics and Rare Diseases
- Microtubule and mitosis dynamics
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Colorectal Cancer Screening and Detection
- Cancer-related Molecular Pathways
- Studies on Chitinases and Chitosanases
University of Gezira
2018-2024
University College Dublin
2024
China Pharmaceutical University
2019-2022
Cairo University
2021
Alexandria University
2021
University of Khartoum
2018
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emergence has resulted in a global health crisis. As consequence, discovering an effective therapy that saves lives and slows the spread of pandemic is concern currently. In silico drug repurposing highly regarded as precise computational method for obtaining fast reliable results. Transmembrane serine-type 2 (TMPRSS2) SARS CoV-2 enzyme essential viral fusion with host cell. Inhibition TMPRSS2 may block or lessen severity...
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...
Background : The catechol-O-methyltransferase ( COMT ) gene is involved in brain catecholamine metabolism, but its association with Parkinson′s disease (PD) risk remains unclear. Objective To investigate the relationship between genetic variants and PD across diverse ancestries. Methods We analyzed 2,251 patients 2,835 controls of European descent using whole-genome sequencing from Accelerating Medicines Partnership-Parkinson Disease (AMP-PD), along 20,427 11,837 10 ancestries genotyping...
Parkinson's disease (PD) is a neurodegenerative disorder with diverse motor, nonmotor, and neuropsychiatric symptoms. Genetic environmental factors contribute to its development.1 However, PD research has predominantly focused on individuals of European descent, over 80% genome-wide association studies (GWAS) centered this group.2 This lack diversity limits our understanding mechanisms creates disparities, preventing the equitable implementation personalized medicine.2-4 Collaborative...
Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons collaborative events that bring together people with different skill sets backgrounds generate resources creative solutions problems. These can be used as training networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools pipelines focus on PD. Resources were created goal helping...
BACKGROUND: There is a current need for new markers with higher sensitivity and specificity to predict immune status optimize immunotherapy use in colon cancer. OBJECTIVE: We aimed investigate the multi-OMICs features associated cancer immunity response immunotherapy. METHODS: evaluated association of data from three datasets (TCGA, CPTAC2, Samstein) antitumor signatures (CD8+ T cell infiltration, cytolytic activity, PD-L1 expression). Using log-rank test hierarchical clustering, we explored...
Abstract Background Coronavirus disease 2019 (COVID-19) struck the world by surprise rising numbers that required prompt governmental and hospital staff reaction to ongoing crisis. A robust preparedness personal protective equipment (PPE) were yet be regarded as our best plan. Methods survey study was conducted on 254 Egyptian house officers using an anonymous web-based questionnaire filled Google Forms after obtaining online informed consent. Results The mean age of participants 25 years....
Objectives To evaluate and compare different polygenic risk score (PRS) models in predicting Parkinsons disease (PD) across diverse ancestries, focusing on identifying the most suitable approach for each population potentially contributing to equitable advancements precision medicine. Methods We constructed a total of 105 PRS individual level data from seven ancestries. First, cross-ancestry conventional comparison was implemented by utilizing 90 known European loci with weighted effects...
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Sleep apnea is a chronic disorder associated with multiple recognized comorbidities. Only few studies focus on evaluating the cognitive profile in patients diagnosed sleep apnea. The aim of study was to assess functions this population using Montreal Cognitive Assessment.The cohort 1,445 adult who were referred for overnight polysomnography, 764 cases and 681 healthy controls. All participants' clinical data comorbidities taken, they all performed polysomnography Assessment.A significantly...
Abstract Background Burkitt’s lymphoma (BL) is an aggressive form of B-cell non-Hodgkin lymphoma. Endemic subtype the disease showed a remarkable statistical and epidemiological association with malaria infection. Despite numerous studies performed to explain this association; molecular mechanisms underlie such coincidence still remain unclear. Dissecting which link Malaria infection can provide insights about reported anticancer action certain antimalarial drugs, namely artemisinin...
Abstract Background Open science and collaboration are necessary to facilitate the advancement of Parkinson’s disease (PD) research. Hackathons collaborative events that bring together people with different skill sets backgrounds generate resources creative solutions problems. These can be used as training networking opportunities. Objective To coordinate a virtual hackathon develop novel PD research tools. Methods 49 early career scientists from 12 countries collaborated in 3-day event May...
Abstract Molecular pathology services for colorectal cancer (CRC) in Sudan represent a significant unmet clinical need. In retrospective cohort study involving 50 patients diagnosed with CRC at three major medical settings Sudan, we aimed to outline the introduction of molecular genetic service and explore features their relationship patient survival clinicopathological characteristics. Mismatch repair (MMR) BRAF (V600E) mutation status were determined by immunohistochemistry. A mismatch...