A5007745733- Glioma Diagnosis and Treatment
- Cerebrospinal fluid and hydrocephalus
- Chromatin Remodeling and Cancer
- Spinal Dysraphism and Malformations
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Neuroblastoma Research and Treatments
- Epilepsy research and treatment
- Cancer Mechanisms and Therapy
- Management of metastatic bone disease
- Intracranial Aneurysms: Treatment and Complications
- Sarcoma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurofibromatosis and Schwannoma Cases
- Neonatal and fetal brain pathology
- Neuroendocrine Tumor Research Advances
- Brain Metastases and Treatment
- Testicular diseases and treatments
- Intraocular Surgery and Lenses
- Craniofacial Disorders and Treatments
- Tumors and Oncological Cases
- Ocular Disorders and Treatments
- Advanced Electron Microscopy Techniques and Applications
Burdenko Neurosurgery Institute
2015-2024
Central Clinical Hospital and Polyclinic
2024
Ministry of Health of the Russian Federation
2020-2023
Central Scientific Research Institute of Traumatology and Orthopedics
2023
Research Center of Neurology
2014
Hemispherectomy is a recognized option in the treatment of symptomatic forms intractable focal epilepsy patients with developmental brain malformations and some acquired lesions one hemispheres. The prognosis for an outcome technique important terms indications surgical treatment.We described hemispherectomy its variants analyzed our own experience surgery 40 children. most common (27 cases) pathology was extended unilateral cortical dysplasia polymicro- or pachygyria consequences perinatal...
The study objective was to develop a rational approach for defining the extent of posterior decompression in children with Chiari 1 malformation.Posterior performed 76 malformation, under 18 years age, period between 2001 and 2015. Fifty two (68%) had syringomyelia. Extradural (EDD) 14 (18%) cases, extra-arachnoid duraplasty (EAD) 21 (28%) intra-arachnoid dissection foramen Magendie stenting 20 (26%) cases.Complications occurred 15 (20%) patients, one them being fatal (case fatality rate,...
The article addresses the issue of a combination and relationship between intramedullary spinal cord tumors (IMSCTs) neurofibromatosis (NF).To study, based on large clinical material, features prevalence biological nature in patients different age groups.We analyzed data largest series from all groups who underwent surgery for (541 patients; 586 surgeries; age, 2 months to 72 years).Our findings support potential pathogenetic neurofibromatosis. Astrocytoma was predominant tumor with NF-1,...
Intramedullary spinal cord tumors (IMSCTs) are a rare pathology. They can be found at any age. Our experience with more than 507 surgeries for IMSCTs revealed some differences between pediatric and adult IMSCTs.We used large surgical series to conduct comparative analysis of the main epidemiological characteristics intramedullary in children adults identify possible differences.Prospectively collected data from 224 242 patients operated by one surgeon (YK) last 12 years were...
The article addresses the problem of intramedullary tumors (IMTs) combined with hydrocephalus (HC).The study purpose was to explore, based on large clinical material, occurrence tumors, possible pathogenetic mechanisms its development, effect tumor resection course hydrocephalus, and need timing shunting surgery.We present analyze data largest individual series patients all age groups operated for IMTs spinal cord: 541 patients; 586 operations; from 2 months 72 years.Our findings confirm a...
The paper describes a rare clinical case of intramedullary melanocytoma, provides detailed description pathomorphological study, and addresses the issues differential diagnosis surgical treatment.Описывается редкое клиническое наблюдение интрамедуллярной меланоцитомы. Приведено подробное описание патоморфологического исследования, обсуждаются вопросы дифференциальной диагностики и хирургического лечения.
to develop the algorithm for defining amount of posterior decompression craniovertebral junction in children with syringomyelia combined Chiari-1 malformation.Sixty eight and malformation, under age 18 years, underwent (PDCVJ) period from January 2001 June 2016. Seven (10%) patients extradural (EDD), 16 (24%) extra-arachnoid duraplasty (EAD), 25 (37%) intra-arachnoid dissection (IAD) duraplasty, 20 (29%) PDCVJ placement a fourth ventricle-subarachnoid shunt.Clinical improvement occurred 85%...
In this case report, we describe the use of expansive suboccipital cranioplasty in Chiari-1 malformation. The technique improves efficacy and safety treatment for can be used as an adjunct together with any variant posterior fossa decompression, including duroplasty extradural decompression.В статье на клиническом примере описана техника экспансивной краниопластики (реконструкции) задней черепной ямки (ЗЧЯ) при аномалии Киари-1 (АК-1). Цель применения методики - повышение эффективности и...
One of the main manifestations posterior cranial fossa (PCF) tumors is development hydrocephalus (HC) symptoms that in most cases are reason for examination and diagnosis [1, 2]. According to literature, rate shunt surgery after removal PCF children's population 18-40% [3-9]. Hydrocephalus remaining tumor requiring further treatment called persistent hydrocephalus. The above figures based on outcomes children, which were obtained as early 1990s. Given these facts, we conducted a modern study...
The paper describes a new technology - application of resorbable plates and pins for securing laminotomy flap in children's neurosurgery. Four patients were operated on at our clinic. We describe detail surgical technique compare it with traditional fixation using ligatures.Работа посвящена применению новой технологии фиксация ламинотомированного лоскута резорбируемыми пластинами и пинами в детской нейрохирургической практике. В нашей клинике прооперированы 4 пациента. Подробно описана...
Introduction. Atypical teratoid/rhabdoid tumor (ATRT) of the central nervous system (CNS) belongs to embryonic group, occurs mainly in children under 3 years age and is characterized by an extremely aggressive clinical course unfavorable outcome. However, there not enough data about heterogeneity CNS ATRT role therapeutic prognostic factors patients 1 year 1–3 age. The aim this study was conduct a comparative evaluation treatment results with indicated groups. Materials methods. From 2008...
Chordoid glioma is a rare slow-growing tumor of the central nervous system. Available world experience includes no more than 200 cases (lesion third ventricle in absolute majority cases). Recognition and treatment chordoid are currently difficult problems due to small incidence this disease.To describe clinical manifestations surgical considering literature data own experience.There were 12 patients (6 men 6 women) with between 2004 2023 (10 lesion ventricle, 1 - lateral pineal region). Only...
Posterior cranial fossa tumors are the most common neuro-oncological pathology of childhood. More than half them located along midline, occupying cerebellar vermis and 4th ventricle cavity. Historically, these were operated on with patient in sitting position. This tendency has significantly changed last 30 years. For example, 95% all operations Japan now performed lying position; for US Europe, figures 80 60%, respectively. global switching to position is mainly associated a high risk...
Glioneuronal tumors (GNT) are usually found in children (less than 1.5% of all neoplasms the brain). With rare exceptions, they benign and manifest only by epilepsy, which is quite often resistant to treatment with AE drugs. Tumor removal helps cope epileptic seizures, however, a number issues regarding diagnosis surgical (interpretation morphological data classification, epileptogenesis topography epileptogenic zone, value intraoperative invasive EEG optimal volume resection) remain...
The article describes in detail a large modern clinical series of patients operated on for spinal cord epidermoid cysts.the study aim was to comprehensively investigate the epidemiological and peculiarities cysts evaluate immediate long-term results their surgical treatment.We describe analyze outcomes 20 with cysts. This sample selected from 554 intramedullary tumors 365 dysraphism (aged 2 months 72 years) who were by first author 2002-2017.Our findings confirm high efficacy low risk...
Introduction . The development of technologies for molecular genetic typing tumors the central nervous system (CNS) has significantly increased specificity traditional histological and immunohistochemical research methods. As a result, completely new variants have appeared, as well improved results treatment with long-term favorable prognosis. Thanks to biomarkers, among morphologically similar small-cell embryonic CNS tumors, extremely rare been identified: ETMR (embryonic tumor multiple...
Improvement of modern neurosurgical technology has given rise to keyhole surgery for a wide range pathologies. Supraorbital trans-eyebrow approach been described in detail small tumors anterior cranial fossa and suprasellar neoplasms. Can we use this less traumatic more complex tumor extending beyond the region?To analyze own experience surgical treatment large giant parasellar via supraorbital approach, identify principles such operations, indications possible limitations.There were 58...
Hemangioblastoma of the filum terminale and cauda equina is a rare tumor nervous system. There are only few case reports in literature. In this manuscript, authors analyze diagnosis treatment patients with disease. MRI data intraoperative images stage-by-stage resection allow one to get an idea about radiological characteristics hemangioblastoma surgical intervention. The discuss world experience consider complications.
Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) is an aggressive malignant that mainly found in younger children and associated with poor prognosis. Our objectives: to present results treatment CNS AT/RT under 3 years age assess impact various prognostic factors on patient survival. The study was approved by Independent Ethics Committee Scientific Council N.I. Pirogov Russian National Research Medical University Ministry Healthcare Federation. included 106...
To evaluate the spectrum of pitfalls and complications after hemisherotomy basing on a retrospective study large consecutive pediatric cohort patients from single institution.One hundred one (med. age - 43 months) with refractory seizures underwent hemispherotomy. Developmental pathology was anatomical substrate disorder in 42 patients. The infantile post-stroke scarring gliosis origin epilepsy majority cases acquired etiology. progressive (RE, S-W TS) etiology rest children (16 cases)....
METHOD: There were 19 pts with MG, who enrolled in the study from May 2010 till March 2014 (10 boys and 9 girls), median age yrs (range, 3-17 yrs). 15 (79%) glioblastoma (GB), 4 (21%) - anaplastic astrocytoma (AA). In 16 tumor was localized supratentorial (84.21%), 3 infratentorial (15.79%). All received resection of (total detected (15.79%), subtotal 13 (68.43%), partial 2 (10.52%), biopsy 1 (5.26%)), local radiation therapy (RT) 55 Gy parallel chemotherapy (CT): TMZ 75 mg/m2 p.o. everyday...
Differential diagnosis of supratentorial ependymomas is particular difficulty in neurooncology due to nonspecific clinical and radiographic findings, a rare seen «classic» morphological picture, immunophenotype. Thanks molecular genetic methods, real-time PCR, it has become possible verify identify their group, on which further prognosis depends.To develop set tests based PCR ependymomas.56 tissue samples were collected from patients with ependymomas, WHO Grade II, anaplastic III. We...
Medulloblastomas of the WNT molecular group (MB-WNT) represent smallest MB and account for only 10 % total. This is characterized by a favorable prognosis. Given aggressive treatment regimens MB, reducing intensity therapy prognostically tumors seems justified. Purpose study – to demonstrate results children with MB-WNT determine impact on survival various prognostic factors. The included 85 patients under age 18 who received were followed up from 1993 2022. Median at diagnosis was years...