A5080154052- Glioma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Brain Tumor Detection and Classification
- Neurological Complications and Syndromes
- MRI in cancer diagnosis
- Radiopharmaceutical Chemistry and Applications
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Technology and Human Factors in Education and Health
- Genetic Neurodegenerative Diseases
- Sarcoidosis and Beryllium Toxicity Research
- Meningioma and schwannoma management
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Vasculitis and related conditions
- Healthcare Systems and Public Health
- Infectious Diseases and Tuberculosis
- Boron Compounds in Chemistry
- Neurological disorders and treatments
Institute of the Human Brain
1998-2025
St Petersburg University
2021
INTRODUCTION : One of the main difficulties in prognosis and treatment planning children with brainstem glioma is rare histological verification diagnosis, which prompts increased attention to non-invasive diagnostics using neuroimaging. OBJECTIVE To study metabolic characteristics thalamic tumors PET/CT 11 Cmethionine (Met) association MRI results. MATERIALS AND METHODS The included results Met 63 aged 3 18 gliomas who underwent contrast-enhanced (CE) C-methionine before treatment. analysis...
Introduction . The radiotracer L-[methyl- 11 C]methionine (Met) has long been considered the tracer of choice in CNS tumors diagnosis using positron emission tomography, combined with computed tomography (PET/CT). However, there are more and logistic arguments for introduction fluorinated amino acids into diagnostics, particular, O -2-[ 18 F]fluoroethyl-L-tyrosine (FET), which our institute developed its own method radiochemical synthesis. aim study was to compare acid radiotracers (FET)...
INTRODUCTION: Since 2016, molecular markers, in particular, mutations isocitrate dehydrogenase (IDH) 1 and 2, have been introduced as a classifying feature of cerebral gliomas that provided superior prognostication. The search for non-invasive biomarkers the profile is necessary to improve quality preoperative diagnostics, identify patients with good poor prognosis determine treatment tactics. OBJECTIVE: Was study relationship between IDH genotype diffuse metabolic according results PET/CT [...
Primary central nervous system vasculitis is still a challenge due to rarity of disease, unspecific clinical and neurological presentation, as well low specificity MRI laboratory tests.
Prognosis of
Differentiation of tumor recurrence from radiation-induced brain changes is the main challenge neuroimaging in patients with treated cerebral tumor. The review presents limitations structural imaging and additional opportunities perfusion techniques, proton magnetic resonance spectroscopy positron emission tomography discriminating recurrent radiation injury.
With improved treatment for cerebral gliomas leading to longer survival, late rare complications of radiation therapy on the brain are more frequently observed. The paper presents results positron emission tomography (PET) with [11C]methionine in 4 patients malignant glioma, whom phenomenon transient diffuse high uptake cortex was detected during monitoring. unilateral posterior portion hemisphere stereotyped and easy recognize. Nevertheless amino acid PET did not match structural...
Positron emission tomography (PET) with amino acid-based radiopharmaceuticals is considered as an effective method to diagnose continued growth of cerebral gliomas, but the variability 11C-methionine uptake by brain lesions different genesis after combined treatment still remains poorly understood. The aim this study was explore information value PET in delimitating progression gliomas and stable disease assess risk tumor recurrence at values index. MATERIAL AND METHODS: We performed a...
Atypical teratoid/rhabdoid tumor (AT/RT) of the central nervous system (CNS) is an aggressive malignant that mainly found in younger children and associated with poor prognosis. Our objectives: to present results treatment CNS AT/RT under 3 years age assess impact various prognostic factors on patient survival. The study was approved by Independent Ethics Committee Scientific Council N.I. Pirogov Russian National Research Medical University Ministry Healthcare Federation. included 106...
Objective – study of the diagnostic capabilities MRI and PET/CT scanners available user programs for processing DICOM-images in implementation preoperative planning stereotactic interventions patients with deep cerebral gliomas terms fusion scans a brain. Material methods. 35 surgeries (biopsies treatment cryoablations) were preplanned then conducted brain deep-seated tumors. Patients underwent MRI-scanning conditions scanning tumor-specific radiotracer 11C-methionine targeting period....
The aim of the study was to assess diagnostic value MR diffusion imaging (DWI) and hybrid positron emission computed tomography (PET/CT) with [11C]methionine for glioma grading compare spatial distribution restriction uptake abnormalities within a tumor. Material methods: MRI sequences PET/CT were performed 46 patients untreated histologically proven brain gliomas. Quantitative evaluation included minimal apparent coefficient (ADCmin) in tumor maximum ratio, measured as ratio highest count...
In recent years, positron emission tomography (PET) with amino acid radiopharmaceuticals has assumed increasing importance in the diagnosis of brain tumors and it already become an additional method examination along magnetic resonance imaging (MRI) many diagnostic centers. The markers somatostatin receptors seem to be most promising for PET meningiomas. provides important information changes unknown origin more accurate about tumor boundaries, which is necessary biopsy, neurosurgery,...
An increased amino acid metabolism is characteristic for many brain malignancies. Combined positron emission and computed tomography (PET/CT) with radiolabeled acids often used in recognizing the tumor nature of structural lesion detected on MRI. On 11 C-methionine PET/CT a hallmark an uptake, topographically coinciding However, high uptake not specific could be seen number non-tumor diseases. The paper presents three observations abscess, radiological metabolic data which MRI simulated...
A 44-year-old man after combined left temporal low-grade glioma treatment presented with daily multiple series of seizures. MRI demonstrated diffuse cortical swelling in the frontal lobe intensive gyral enhancement. PET [11C]methionine (PET-MET) revealed increased radiotracer uptake strictly confined to ribbon cerebral hemisphere, which persisted for 3 months. Tumor recurrence was suggested, and biopsy performed. No evidence recurrent tumor found. During a 2-year follow-up, enhancement...
The purpose of the study was to explore correlation between 11С-methionine (Met) uptake measured by combined positron emission and computed tomography (PET/CT) in newly diagnosed cerebral gliomas tumor proliferative activity as Ki-67 labeling index (Ki-67 LI). results PET/CT with (PET-Met) 236 adult patients pretreated glial brain tumors were included retrospective analysis. final diagnosis glioma according WHO classification CNS (2007) based on both histology immunohistochemistry using...