A5010564331- Sphingolipid Metabolism and Signaling
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Endoplasmic Reticulum Stress and Disease
- Electrolyte and hormonal disorders
- Pharmacological Receptor Mechanisms and Effects
- Protein Kinase Regulation and GTPase Signaling
- Lipoproteins and Cardiovascular Health
- Heart Rate Variability and Autonomic Control
- Cardiac Fibrosis and Remodeling
- Lipid metabolism and disorders
- Ion Transport and Channel Regulation
- Lipid Membrane Structure and Behavior
- Atherosclerosis and Cardiovascular Diseases
- Potassium and Related Disorders
- Receptor Mechanisms and Signaling
- Viral Infections and Outbreaks Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lysosomal Storage Disorders Research
- Cancer, Lipids, and Metabolism
- Biomarkers in Disease Mechanisms
Institut du Savoir Montfort
2021-2024
Hartford Hospital
2024
Hartford Financial Services (United States)
2024
Centre Hospitalier de l’Université de Montréal
2023
Institut de Recherches Médicales et d’Etudes des Plantes Médicinales
2020-2022
Jewish General Hospital
2017-2021
Montfort Hospital
2021
University of Ottawa
2021
Dalhousie University
2013-2020
Trinity College Dublin
2016-2019
We investigated whether plasma long-chain sphingoid base (LCSB) concentrations are altered by transient cardiac ischemia during percutaneous coronary intervention (PCI) in humans and examined the signaling through sphingosine-1-phosphate (S1P) cascade as a mechanism underlying S1P cardioprotective effect myocytes. Venous samples were collected from either sinus (n = 7) or femoral vein 24) of 31 patients at 1 5 min 12 h, following induction myocardial elective PCI. Coronary levels LCSB...
Natriuretic peptides (NPs) are critical regulators of the cardiovascular system that currently viewed as possible therapeutic targets for treatment heart disease. Recent work demonstrates potent NP effects on cardiac electrophysiology, including in sinoatrial node (SAN) and atria. NPs elicit their via three receptors (NPR-A, NPR-B NPR-C). Among these receptors, NPR-C is poorly understood. Accordingly, goal this study was to determine ablation structure arrhythmogenesis. Cardiac function were...
Background: Atrial fibrillation (AF) commonly occurs in hypertension and association with elevated Ang II (angiotensin II) levels. The specific mechanisms underlying II–mediated AF are unclear, interventions to prevent the effects of lacking. NPs (natriuretic peptides), which elicit their through NP receptors, including NPR-C peptide receptor-C), cardioprotective hormones that affect cardiac structure function. Methods: This study used wild-type knockout (NPR-C −/ − ) mice investigate (3...
Background: Ventricular tachyarrhythmias are the most common and often first manifestation of coronary heart disease lead to sudden cardiac death. Early detection/identification acute myocardial ischaemic injury at risk for malignant ventricular arrhythmias in patients remains an unmet medical need. In present study, we examined sphingolipids level after transient ischaemia following temporary artery occlusion during percutaneous intervention (PCI) determined role as a novel indicator early...
Atrial fibrillation (AF) is prevalent in diabetes mellitus (DM); however, the basis for this unknown. This study investigated AF susceptibility and atrial electrophysiology type 1 diabetic Akita mice using vivo intracardiac electrophysiology, high-resolution optical mapping preparations, patch clamping isolated myocytes. qPCR western blotting were used to assess ion channel expression. highly susceptible association with increased P-wave duration slowed conduction velocity. In a second model...
Sinoatrial node (SAN) disease mechanisms are poorly understood, and therapeutic options limited. Natriuretic peptide(s) (NP) cardioprotective hormones whose effects can be mediated partly by the NP receptor C (NPR-C). We investigated role of NPR-C in angiotensin II (Ang II)-mediated SAN mice. Ang caused due to impaired electrical activity myocytes increased fibrosis. Strikingly, treatment NPR-C-/- mice worsened disease, whereas co-treatment wild-type with a selective agonist (cANF) prevented...
Abstract Background: Presence of macro- and microvascular complications in patients with diabetes mellitus (DM) is not only related to chronic hyperglycemia represented by glycated hemoglobin (HbA1c) but also acute glycemic fluctuations (glycemic variability, GV). The association between GV DM completely clear. Aim our study was evaluate MAGE index type 2 verify presence complications. Methods: 99 were included the study. Every patient had done big profile, from which calculated....