A5101719276- Quinazolinone synthesis and applications
- Microwave-Assisted Synthesis and Applications
- Synthesis and biological activity
- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Synthesis and Biological Evaluation
- Reproductive biology and impacts on aquatic species
- MicroRNA in disease regulation
- Synthesis and Reactions of Organic Compounds
- Synthesis and Characterization of Heterocyclic Compounds
- Pharmaceutical and Antibiotic Environmental Impacts
- Cancer Treatment and Pharmacology
- Organ Donation and Transplantation
- Mycobacterium research and diagnosis
- Organ Transplantation Techniques and Outcomes
- Biochemical and Molecular Research
- Air Quality Monitoring and Forecasting
- Noise Effects and Management
Guiyang Medical University
2020-2025
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2022-2025
Suzhou University of Science and Technology
2015
Di-n-butyl phthalate (DBP) is known to have adverse effects on reproduction in mammals and pervasive the aquatic environment. The objective of present study was investigate whether long-term exposure low concentrations DBP can affect fish reproduction. In this study, zebrafish (Danio rerio) embryos (F0 ) were exposed (4.9, 13.6 43.8 μg/L) from 2 hours post-fertilization until sexual maturation. results demonstrate that chronic (43.8 impaired reproductive function zebrafish, as verified by...
This study explored the regulation of different perfusion methods on ischemia-reperfusion injury in donor kidneys. In this study, renal cortical/medullary tissue specimens were collected from porcine kidneys donors using at various time points. Hematoxylin and eosin (H&E) staining was used to test histological differences. Differentially expressed micro-ribonucleic acids (miRNAs) identified by miRNA transcriptome sequencing. Reverse transcription-polymerase chain reaction (RT-PCR) tests...
Abstract To discover new Werner (WRN) helicase inhibitors, a series of N -aryl-2-trifluoromethyl-quinazoline-4-amine derivatives were designed and synthesized through structural optimization strategy the anticancer activities 25 target compounds against PC3, K562, HeLa cell lines evaluated by MTT assay. Some it exhibited excellent inhibitory activity three different cancer cells. In order to further verify whether these is dependent on WRN, PC3 cells with WRN overexpression (PC3-WRN)...
Modern people spend more than 90% of their life indoors and therefore the indoor environment quality has great impact on body health working efficiency human beings. A series detectors thus been developed to evaluate quality. Nevertheless, these devices are either expensive or too simple. In this paper, a portable detector model, basing Lego Blocks Principle, is proposed. Users able select sensing modules according preference based precision requirements, price constraints size limitations...
A series of new N-aryl-2-trifluoromethylquinazoline-4-amine analogues were designed and synthesized based on structure optimization quinazoline by introducing a trifluoromethyl group into 2-position. The structures the twenty-four newly compounds confirmed 1H NMR, 13C NMR ESI-MS. in vitro anti-cancer activity against chronic myeloid leukemia cells (K562), erythroleukemia (HEL), human prostate cancer (LNCaP), cervical (Hela) target was evaluated. Among them, 25d, 25f, 25h, 25i showed...
In this work, a series of 2-(trifluoromethyl)quinolin-4-amine derivatives were designed and synthesized through structural optimization strategy as microtubule-targeted agents (MTAs) their cytotoxicity activity against PC3, K562 HeLa cell lines evaluated. The half maximal inhibitory concentration (IC50) 5e, 5f 5o suggested that potency anti-proliferative activities better than the combretastatin A-4. Compound 5e showed higher in vitro with IC50 values 0.49 µM, 0.08 µM 0.01 respectively....