A5066642665- Quinazolinone synthesis and applications
- Synthesis and biological activity
- Catalytic C–H Functionalization Methods
- Synthesis and Biological Evaluation
- Photopolymerization techniques and applications
- Catalytic Cross-Coupling Reactions
- Silicon and Solar Cell Technologies
- Advanced Polymer Synthesis and Characterization
- Electrospun Nanofibers in Biomedical Applications
- Silicon Nanostructures and Photoluminescence
- Thin-Film Transistor Technologies
- Tribology and Lubrication Engineering
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Catalytic Reactions
- Toxin Mechanisms and Immunotoxins
- Metallurgical and Alloy Processes
- Photonic and Optical Devices
- Oxidative Organic Chemistry Reactions
- Advanced Sensor and Energy Harvesting Materials
- Gear and Bearing Dynamics Analysis
- Cyclopropane Reaction Mechanisms
- Microwave-Assisted Synthesis and Applications
- Dental materials and restorations
- Aerogels and thermal insulation
- Quasicrystal Structures and Properties
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2022-2024
Guiyang Medical University
2019-2024
Nanjing University of Posts and Telecommunications
2021
Shanghai University of Engineering Science
2021
WinnMed
2021
Zhejiang University
2000-2020
State Key Laboratory of Modern Optical Instruments
2020
Zhejiang Research Institute of Chemical Industry
2020
Beijing University of Chemical Technology
2015-2019
Huaqiao University
2018-2019
A series of Norrish type I photoinitiators (NASs), which are naphthalimide aryl sulfide derivatives, prepared. The potential mechanism involved in the photolysis NASs under UV LED at 405 nm is investigated by steady-state photolysis, nuclear magnetic resonance, electron spin fluorescence spectroscopy, cyclic voltammetry, and laser flash calculating bond dissociation energies C–S bonds NASs. as-prepared NAS5 NAS6 can efficiently initiate free radical photopolymerization (methyl)acrylate...
A novel approach to trisubstituted oxazoles has been developed that is based upon an iodine-mediated aerobic oxidative cyclization of enaminone derivatives. This transition-metal-free procedure was highly efficient and involved the removal four hydrogen atoms under mild conditions.
A rhodium(III)-catalyzed C–H acylmethylation of tridentate [2,2′-bipyridine]-6-carboxamides was developed. variety could be monoalkylated exclusively at the C3 position with sulfoxonium ylides as carbene precursors, giving 3-alkylated products in high yields. This protocol proceeds through a rollover cyclometalation pathway, has broad range scope substrates, and exhibits excellent functional group tolerance.
A palladium-catalyzed ortho-silylation of aryl iodides/arylsilylation oxanorbornadiene/retro-Diels–Alder domino reaction was developed. Such a transformation provides access to various functionalized (Z)-β-substituted vinylsilanes with exclusive selectivity using hexamethyldisilane as bis-silylation reagent and 2,3-dicarbomethoxy-7-oxanorbornadiene (ONBD) an ortho-C–H activator ethylene surrogate. variety vinylgermanes vinylstannanes were also obtained under mild conditions. This...
A palladium-catalyzed three-component reaction of aryl iodides, norbornenes, and hexamethyldisilane/hexamethyldigermane has been developed for the assembly highly functionalized disilanes/digermanes. The potential synthetic utility this methodology was highlighted by late-stage manipulations natural products iterative C-H bis-silylation synthesis decorated arenes.
The enormous depth complexity of the human plasma proteome poses a significant challenge for current mass spectrometry-based proteomic technologies in terms detecting low-level proteins plasma, which is essential successful biomarker discovery efforts. Typically, single-step analytical approach cannot reduce this intrinsic complexity. Current simplex immunodepletion techniques offer limited capacity low-abundance proteins, and integrated strategies are thus desirable. In respect, we...
Sustained drug release has attracted increasing interest in targeted therapy. However, existing methods of therapy suffer action time, large fluctuations the effective concentration drug, and risk side effects. Here, a biodegradable composite polybutylene adipate co-terephthalate/polyvinylpyrrolidone (PBAT/PVP) consisting electrospun hollow microspheres as sustained-released carriers is presented. The as-prepared PBAT/PVP composites show faster degradation rate (Erlotinib) than that PBAT....
The first example of Pd(II)-catalyzed arylation 2,2′-bipyridine-6-carboxamides via a rollover cyclometalation pathway is reported. A diverse range (hetero)aryl iodides could be directly coupled with various in exclusive site-selectivity, which offers distinct entry to arylated 2,2′-bipyridine-6-carboxamides. preliminary mechanistic study supports the Pd(II)-rollover pathway.
The synthesis of 2,3,4-trisubstituted pyrroles <italic>via</italic> base-promoted C–C bond cleavage reaction <italic>N</italic>-propargyl β-enaminones is reported.
Affinity- and chemical-based methods are usually employed to prepare human serum albuminome; however, these remain technically challenging. Herein, we report the development of a two-step precipitation (TSP) method by combined use polyethylene glycol (PEG) ethanol. PEG was newly applied remove immunoglobulin G for albuminome preparation, which is simple, cost effective, efficient compatible with downstream ethanol precipitation. Nonetheless, chemical extraction using TSP may disrupt weak...
Although microfiber (MF) loaded polypeptides have been widely studied in the field of medicine, load control and slow release remain significant challenges. Herein, polybutylene adipate terephthalate (PBAT) hollow porous MFs (HPMFs) were prepared by improving regulating groups structures to address these The capacity HPMFs for loading polypeptide can be improved. Measurements involving use X-ray photoelectron, energy-dispersive, ultraviolet (UV) spectroscopies conjunction with scanning...
This paper reported a water-borne polysiloxane-modified benzophenone macromolecular photoinitiator (WPSHBP), whose characteristics of the photopolymerization, migration photolysis fragments, volatility, and reduction oxygen inhibition were discussed in detail. WPSHBP has maximum absorption peak at 286 nm, molar extinction coefficient (ε286 nm) is 23200 M−1 cm−1. The photopolymerization rate final double bond conversion system initiated by enhanced with increasing contents triethanolamine...
Abstract A novel series of trifluoromethyl‐containing quinazoline derivatives with a variety functional groups was designed, synthesized, and tested for their antitumor activity by following pharmacophore hybridization strategy. Most the 20 compounds displayed moderate to excellent antiproliferative against five different cell lines (PC3, LNCaP, K562, HeLa, A549). After three rounds screening structural optimization, compound 10 b identified as most potent one, IC 50 values 3.02, 3.45, 3.98...
Aim: A series of novel trifluoromethylquinoline derivatives were designed, synthesized and evaluated for antitumor activities. Methodology: All compounds antiproliferative activity against four human cancer cell lines. Results: Among them, 5a, 5m, 5o 6b exhibited remarkable activities all the tested lines at nanomolar concentrations. Mechanism action studies demonstrated that targeted colchicine binding site, potentially inhibiting tubulin polymerization, further indicated could arrest LNCaP...
C-glycosides are important flavonoids with significant pharmacological activities implicated in anticancer and antioxidative effects. However, their characteristics of metabolism transportation have been rarely investigated. This research aimed to examine the metabolic two active C-glycosides, namely, orientin isoorientin, human liver microsomes (HLMs) rat (RLMs) confirm specific uridine 5'-diphospho glucuronosyltransferase (UGT) isoforms involved glucuronidation by HLMs. Furthermore,...