A5003673200- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Ethnobotanical and Medicinal Plants Studies
- Effects of Radiation Exposure
- Radiation Effects and Dosimetry
- Radiation Dose and Imaging
- Plant Genetic and Mutation Studies
- Carcinogens and Genotoxicity Assessment
- Bone health and treatments
- Radiology practices and education
- Genomics, phytochemicals, and oxidative stress
- Radiation Therapy and Dosimetry
- Radioactivity and Radon Measurements
- Water Quality and Pollution Assessment
- Phytochemistry Medicinal Plant Applications
- Mycobacterium research and diagnosis
- Peripheral Artery Disease Management
- X-ray Diffraction in Crystallography
- African Botany and Ecology Studies
- Electromagnetic Fields and Biological Effects
- Biochemical effects in animals
- Seed and Plant Biochemistry
- Water resources management and optimization
- Heavy metals in environment
- Prostate Cancer Treatment and Research
Ghana Atomic Energy Commission
2014-2024
University of Ghana
2013-2024
Stellenbosch University
2016
University of Cape Town
2015
Universidad de Murcia
2013
Western Carolina University
2013
Noguchi Memorial Institute for Medical Research
2013
Currently, the incidence of female breast cancer has surpassed all other cancers globally. In low-and-middle-income countries (LMICs), is relatively lower than it in high-income (HICs). However, mortality LMICs higher compared to HICs. This may be attributed a lack screening programs for early detection and education on health awareness, population-based registry data, no/limited diagnostic imaging services. paper presents brief overview current burden, challenges faced by LMICs, future...
The chemical quality of groundwater in six district the eastern region beneath different types land use areas Ghana was examined to evaluate effects human activities on groundwater. Analyses indicate that studied area is fresh and generally suitable for most uses. characterised by a facies Ca-HCO3-, Na-Cl mixed Na-Ca-HCO3 weakly mineralised. Anthropogenic disturbances have had continue an impact aquatic ecosystem Ghana. High concentration Cl- TDS were found wells high residential while...
Flavonoids constitute a group of polyphenolic compounds characterized by common gamma-benzo- pyrone structure considered in numerous biological systems to possess antioxidant capacity. Among the different applications flavonoids, its genoprotective capacity against damage induced ionizing radiation stands out, which has been related activity and chemical structure. In this study, we determined frequency appearance micronucleus vivo means assay. This was conducted mice treated with flavonoids...
To explain a paradoxical radiosensitizing effect of rosmarinic acid (RA) on the melanoma B16F10 cells, we analyzed glutathione (GSH) intracellular production this cell (traditionally considered radioresistant) in comparison with human prostate epithelial cells (PNT2) (considered to be radiosensitive). In PNT2 administration RA increased total GSH content during first 3 h (p < 0.01) as well GSH/oxidized (GSSG) ratio all irradiated cultures periods studied (1h and 3h) 0.001), portraying an...
To evaluate the superiority of transcutaneous oxygen pressure (TcPO2) before, during and after peripheral transluminal angioplasty (PTA) in comparison with ankle brachial index (ABI) patients diabetes.40 consecutive diabetes treated by PTA where included. This study shows results their progression for 8 weeks.The TcPO2 increased from 28.11 ± 8.1 to 48.03 8.4 mmHg, weeks (p < 0.001). The ABI 0.48 0.38 0.77 0.39 After PTA, stenosis vessel decreased 58.33 20.07% 21.87 13.57% was determined all...
Although different studies have demonstrated applications of Pycnanthus angolensis extracts in traditional African and Asian medicine, its possible antimutagenic or genoprotective capacities never been explored. We studied these capabilities seed extract (PASE) by means the two micronucleus assays, determining frequency (MN) yield mouse bone marrow (in vivo) human lymphocytes blocked cytochalasin B vitro). PASE exhibited a significant capacity (p < 0.001) against X-rays with protection...
Abstract A detailed study has been carried out on the Densu River and its tributaries to identify chemical characteristics of water, examine hydrological connections among land cover types evaluate relative contributions anthropogenic activities river's pollution. The results indicate that sites closer most urbanized, industrialized agricultural areas are severely impaired. river water was found vary considerably in terms physical properties. slightly alkaline, brackish fresh mixed Ca–Na–HCO...
Radiation exposure is an occupational hazard for diagnostic and interventional radiology workers, potentially leading to chromosomal damage increased cancer risk. This review explores the status of cytogenetic monitoring radiation among workers in Africa. Monitoring Exposure Diagnostic Interventional Radiology Workers Ghana Africa provides a crucial examination safety practices within Ghanaian healthcare sector. We recovered existing literature on surveillance conducted stressing impact...
In recent years extremely low-frequency magnetic fields (ELF-EMF) have become widely used in human activities, leading to an increased chance of exposure ELF-EMF. There are few reports on vivo mammalian genotoxic effects using micronucleus (MN) assays, which generally been as a short-term screening system. We analyzed the possible effect induced by long-term (7, 14, 21, 28 d) 50 Hz ELM-MF mice measuring increase frequency micronucleated polychromatic erythrocyte their bone marrow (MNPCEs)...
Endothelial nitric oxide synthase (eNOS) variants have been found to be associated with several vascular disorders as well the pathogenesis of sickle cell disease (SCD) complications such vaso-occlusive crises (VOC). Studies on eNOS gene among SCD patients are rare in Ghana and other African countries. The current study aimed determine a possible association between (variable number tandem repeats intron 4 T786C) Ghanaian patients. This was cross-sectional involving 89 HbSS 46 without...
to address the challenge of inadequate and non-equitable distribution diagnostic imaging equipment, countries are encouraged evaluate installed systems undertake adequate monitoring ensure equitability. Ghana´s medical resources have been analyzed in this study evaluated against status other countries.data on registered equipment were retrieved from database Nuclear Regulatory Authority analyzed. The equipment/population ratio was mapped out graphically for 16 regions Ghana. Comparison made...
Journal Article Evolution of diagnostic reference levels in Spanish intraoral radiology Get access M. Alcaraz, Alcaraz * 1Department Radiology and Physical Medicine, Faculty Medicine/Dentistry, University Murcia, Campus Espinardo, Murcia 30100,Spain *Corresponding author: mab@um.es Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Velasco, Velasco Y. Martínez-Beneyto, Martínez-Beneyto 2Department Stomatology, Alcaraz-Saura, Alcaraz-Saura E. G. D. Achel, Achel...
The relative abundance of urokinase plasminogen activator (uPA) and inhibitor type-1 (PAI-1) in transurethral resections the prostate (TURP) has been shown to correlate with disease state. objective this study was assay for uPA PAI-1 needle biopsies, test their potential as predictive markers cancer (PCa). levels were determined 111 patients (55 PCa; 56 benign prostatic hyperplasia (BPH)), using FEMTELLE enzyme-linked immunosorbent (ELISA) assay. concentrations PCa BPH differed significantly...
Bovine tuberculosis is an important zoonotic disease transmissible through aerosols inhalation and the ingestion of contaminated milk meat from cattle. Abattoirs in Ghana mainly depend on post-mortem examinations as means diagnosing presence mycobacterium (beef). A Ziehl-Neelsen microscopy was used to investigate Mycobacterium bovis Acid-Fast Bacilli (AFBs) beef samples Kumasi Metropolitan abattoir; thereby vetting at abattoir. Lesioned lung tissues calcified or puss-filled thoracic lymph...
In radiation oncology, the modulation of bystander effect is a target both for destruction tumor cells and to protect healthy cells. With this objective, we determine whether radioprotective capacity rosmarinic acid (RA) can affect intensity these effects. Genoprotective was obtained by determining micronuclei frequencies in vivo vitro assays cell survival determined (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay) (MTT) assay three lines (PNT2, TRAMPC1 B16F10), direct...
Intrinsic tumour radioresistance limits the benefit of radiotherapy. Targeted treatment modalities that are singly effective for triple-negative breast cancer lacking, partly due to paucity relevant targets as they devoidof human epidermal growth factor receptor 2 (HER-2), progesterone (PR), and oestrogen (ER); or resistance single-target therapies a consequence cellular heterogeneity. Concomitant targeting cell signaling entities other than HER-2, PR ER may sensitise tumours In this study,...