Clinical efforts and research on liver diseases have been scarce in sub-Saharan Africa. The first Conference Liver Disease Africa (Nairobi, Sept 13–15, 2018), gathering all stakeholders from the continent, is a welcome step towards greater attention to problem, important issue of cirrhosis. Cirrhosis-related deaths doubled between 1980 2010, Central African Republic, Gabon, Malawi, Uganda, Cote d'Ivoire were among highest 10% countries for these 2010.1Mokdad AA Lopez AD Shahraz S et al.Liver...

Effective treatment and management of sickle cell disease (SCD) has been a challenge in Africa over the years. Hematological parameters are very useful profiles effective disease. However, there is scarcity studies on hematological SCD Ghana. This study aimed at determining among patients with vaso-occlusion, those steady state as well healthy controls teaching hospital Ghana.This was cross-sectional involving total 628 subjects, including 148 HbAA controls, 208 HbSS state, 82 HbSC 156...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is shed in the stool of infected individuals and can be detected sewage wastewater contaminated with stool. This study aimed at detecting virus its potential survival Ghana. The cross-sectional included samples from 16 validated environmental surveillance sites 7 regions A total 354 composed (280) (74) were collected November 2020 to 2022. Overall, 17% positive for SARS-CoV-2 by real-time PCR, 6% 11% wastewater. highest number was...

Achieving disease control is the goal of asthma management. Serum or sputum eosinophil counts have been known traditional means assessing eosinophilic airway inflammation in asthma, which vital predicting response to corticosteroid therapy ultimately promotes disease. Evidence suggests that fraction exhaled nitric oxide (FeNO) may be a more useful non-invasive surrogate biomarker for assessment and could help with timely adjustment inhaled uncontrolled patient. The relationship between FeNO...

Hepatitis B virus (HBV) infection is endemic in Ghana and chronic kidney disease patients on haemodialysis are a high-risk group for HBV infection. We determined the prevalence of overt occult among at Korle Bu Teaching Hospital Ghana. 104 consenting End Stage Renal Disease long-term were recruited study their socio-demographic, clinical laboratory information obtained using structured questionnaire. All participants tested hepatitis surface antigen (HBsAg). The HBsAg-negative re-tested...

Pharmacogenetics has a potential for optimizing drug response and identifying risk of toxicity patients. knowledge healthcare professionals the unmet need pharmacogenetics education in health training institutions are some challenges integrating into routine medical practice.To assess among faculty members Ghana.Semi-structured questionnaires were used to interview from selected public private hospitals. Faculty also interviewed.The respondents Medical doctors 42 (46.7%), Pharmacists 29...

Persistent hyperglycaemia is a hallmark of Diabetes Mellitus (DM). It causes increased production free radicals, especially reactive oxygen species (ROS), - resulting in oxidative stress. Reactive Oxygen Species have been implicated the development haematological complications patients with diabetes. Superoxide Dismutase (SOD) one most effective antioxidant enzyme defense systems against radicals.From February through May 2014, we assessed relationship between stress and profiles among...

There is an increasing prevalence of cardiovascular diseases (CVDs) and risk factors in HIV patients as the levels AIDS-related mortality morbidity decrease. Metabolic syndrome (MetS) accumulation various CVD that predict occurrence CVDs. We investigated MetS associated treated with combination antiretroviral therapy (cART), cART-naïve patients, non-HIV controls.In a case-control design, 158 cART-treated 150 156 controls were recruited from periurban hospital Ghana. A structured...

Artemisinin-based combination therapy (ACT) is the first-line treatment for uncomplicated malaria in Ghana. Artemisinin (ART) tolerance Plasmodium falciparum has arisen Southeast Asia and recently, parts of East Africa. This ascribed to survival ring-stage parasites post treatment. The present study sought assess characterize correlates potential ART based on post-treatment parasite clearance, ex vivo vitro drug sensitivity, molecular markers resistance P. isolates from children with...

Foetal haemoglobin has been implicated in the modulation of sickle cell crisis. Its level is generally inversely proportional to severity disease (SCD) for a given phenotypes. The main aim therapy vaso-occlusive crisis (VOC), which hallmark SCD, reduce chances sickling through prevention polymerization HbS. One way preventing this by increasing foetal levels.To determine relationship between HbF levels and frequency SCD patients Ghana.A longitudinal retrospective survey covering period 30...

The present study sought to investigate the common abnormalities and mtDNA mutations in sperm of Ghanaian men attending fertility Clinic at Korle-Bu Teaching Hospital (KBTH). therefore provides a baseline data cross-section on referral clinic KBTH.The semen 55 were collected from Urology Obstetrics Gynaecology Departments KBTH. Demographic clinical also using questionnaires. Semen analyses performed followed by amplification purification total DNA extracted semen. Sequencing amplicons was...

Hepatitis C virus (HCV) infection is a blood borne that remains potentially transmissible through transfusions. Sickle cell disease (SCD) common inheritable haemoglobinopathy in Ghana requires multiple transfusions as part of its management. The SCD patient therefore at high risk HCV infection; however, data on the occurrence patients has not been documented Ghana. This study sought to determine prevalence and genotypes patients.This was cross-sectional which enrolled 141 sickle-cell from...

Soluble adhesion molecules are involved in the gathering and joining of inflammatory cells to vascular endothelium. Therefore, they serve as potential markers endothelial dysfunction diseases including sickle cell disease (SCD). In Ghana, there scarcely any report on levels among SCD patients. The current study aimed determine plasma ICAM-1, VCAM-1 E-Selectin patients steady state, complications controls.This was a cross-sectional involving 60 HbAA controls, 46 HbSS 57 VOC, 18 HbSC 21 with...

Endothelial nitric oxide synthase (eNOS) variants have been found to be associated with several vascular disorders as well the pathogenesis of sickle cell disease (SCD) complications such vaso-occlusive crises (VOC). Studies on eNOS gene among SCD patients are rare in Ghana and other African countries. The current study aimed determine a possible association between (variable number tandem repeats intron 4 T786C) Ghanaian patients. This was cross-sectional involving 89 HbSS 46 without...

Sickle cell disease (SCD) is an inherited blood disorder that can result in vasculopathy and end organ damage. Angiogenesis has been implicated as a key contributing factor to vascular mediated tissue injury SCD. The relative plasma levels of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), endothelial growth (VEGF) greatly influence angiogenesis. Dysregulation these factors, leading pro-angiogenic state SCD patients, documented the developed world but there very little data Africa. There...

Warfarin is a widely prescribed anticoagulant with narrow therapeutic window for thromboembolic events. displays large individual variability in dose requirements. The purpose of this study to assess the contribution patient-specific and genetic risk factors requirements patients on either high or low warfarin maintenance Ghana. Blood samples were collected from 141 (62 males, 79 females) Ghanaian stable determine their INR. Influence patient specific gene variations within VKORC1, CYP2C9...

Buruli ulcer (BU) is a skin disease caused by Mycobacterium ulcerans and the second most common mycobacterial after tuberculosis in Ghana Côte d'Ivoire. M. produces mycolactone, an immunosuppressant macrolide toxin, responsible for characteristic painless nature of infection. Secondary infection ulcers before, during treatment has been associated with delayed wound healing resistance to streptomycin rifampicin. However, not much known bacteria causing these infections as well antimicrobial...

Abstract Autoantibodies, which are antibodies that target self-epitopes, have considerable diagnostic, prognostic and predictive value in specific autoimmune diseases. Various infectious agents been linked via numerous mechanisms to the formation of different autoantibodies. Therefore, estimating prevalence autoantibodies anti-infectious populations is high importance. Different genetic environmental pressures, such as these found Ghana’s geographical provinces, may affect In this study, we...

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (COVID-19) pandemic devasted the general life of people and various human activities across globe, Ghana is no exception. This led to development vaccines within record time combat morbidity mortality associated with virus. In Ghana, COVID-19 were introduced in addition existing protocols. However, have adverse events among those who received them. this study, we determined prevalence some common its sociodemographic...

Malignancies affecting the gastrointestinal tract are among principal threats to global public health. In Ghana, these cancers responsible for a significant number of hospitalizations and mortalities at major health facilities across country. The increasing incidence malignancies necessitates an investigation association between lifestyle (modifiable risk factors) disorders.To determine patients attending Korle Bu Teaching Hospital (KBTH).This was cross-sectional prospective study where...

OPINION article Front. Med., 12 May 2020Sec. Infectious Diseases – Surveillance, Prevention and Treatment Volume 7 - 2020 | https://doi.org/10.3389/fmed.2020.00216

Abstract Background and Aims Liver fibrosis leading to chronic liver disease (CLD) is a major cause of morbidity, mortality health‐care expenditure worldwide. The “gold standard” for diagnosis staging histological analysis tissue obtained by biopsy, an invasive procedure. Therefore, there the need identify noninvasive inexpensive markers fibrosis. This study aimed at evaluating correlation hyaluronic acid (HA) 25‐hydroxyvitamin D (25‐OH vitamin D) serum levels as with histologically staged...

OPINION article Front. Med., 08 July 2016Sec. Gastroenterology Volume 3 - 2016 | https://doi.org/10.3389/fmed.2016.00031

Background: Micronutrients such as coper, zinc and selenium are essential to the functioning of nervous system their deficiencies is a critical concern for cerebral palsy children. The aim this study was investigate micronutrient levels antioxidant status in pediatric patients compare them neurologically normal children Accra, Ghana. Method: Twenty seven with (0-14 years) 17 age-bracket matched neurological controls were recruited. Three milliliters venous blood drawn from each participant...