A5004520362- Pneumonia and Respiratory Infections
- Neonatal and fetal brain pathology
- Malaria Research and Control
- Cerebral Palsy and Movement Disorders
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Metabolism and Genetic Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Ethics and Legal Issues in Pediatric Healthcare
- Cardiovascular Issues in Pregnancy
- Genomic variations and chromosomal abnormalities
- Neonatal Respiratory Health Research
- Epilepsy research and treatment
- Antimicrobial Resistance in Staphylococcus
- Autism Spectrum Disorder Research
- melanin and skin pigmentation
- Prenatal Screening and Diagnostics
- Bacterial Identification and Susceptibility Testing
- Infant Development and Preterm Care
- ATP Synthase and ATPases Research
- Child Nutrition and Water Access
- Bacterial Infections and Vaccines
- Drug-Induced Hepatotoxicity and Protection
- Computational Drug Discovery Methods
- Neuroinflammation and Neurodegeneration Mechanisms
University of Ghana
2010-2024
Korle Bu Teaching Hospital
2008-2021
National Institute of Health
2020
Abstract Background Artesunate-amodiaquine (AS+AQ) and artemether-lumefantrine (AM-L) are efficacious artemisinin combination therapy (ACT) regimens that have been widely adopted in sub-Saharan Africa. However, there is little information on the efficacy of these subsequent episodes beyond 28 days, or safety repeated treatments. Methods Children aged six months to 14 years with uncomplicated malaria were randomly assigned treatment AS+AQ (n = 116), AM-L 111). Recruited subjects followed-up,...
Genome sequencing is a powerful and comprehensive test that detects multiple variants of different types. The interrogation across the genome enables identification molecular diagnoses (MMDs) in single individual. In this retrospective study, we describe individuals whom MMDs were associated with proband's indication for testing (IFT), secondary findings, or incidental findings. An MMD considered where at least one findings primary IFT all are classified as either likely pathogenic...
Background: Whole genome sequencing analysis (WGSA) provides the best resolution for typing of bacterial isolates and has potential identification transmission pathways. The aim study was to apply WGSA elucidate possible events involved in two suspected Staphylococcus aureus hospital outbreaks Ghana describe genomic features S. sampled outbreaks. Methods: carried out at Korle-Bu Teaching Hospital Lekma where occurred 2012 2015, respectively. collected from hospitals were three sources...
Abstract Rubinstein–Taybi syndrome (RSTS) is an autosomal dominant disorder, caused by loss‐of‐function variants in CREBBP or EP300 . Affected individuals present with distinctive craniofacial features, broad thumbs and/or halluces, and intellectual disability. RSTS phenotype has been well characterized of European descent but not other populations. In this study, from diverse populations were assessed clinical examination facial analysis technology. Clinical data 38 14 different countries...
Antibiotic use not only selects for resistance in pathogenic bacteria, but also commensal flora of exposed individuals. Little is known epidemiologically about antibiotic relation to people with HIV infection sub-Saharan Africa. This study investigated the carriage resistant bacteria among infected children at a tertiary hospital Ghana. One hundred and eighteen positive were recruited Korle-Bu Teaching Hospital Ghana nasopharyngeal specimens collected from them. The cultured isolates...
This study was carried out primarily to evaluate the public health burden related Streptococcus pneumoniae in Ghana and provide preliminary molecular epidemiological data on organism. Invasive nasopharyngeal specimens were screened for S. pneumoniae, isolates subjected serotyping, multilocus sequence typing (MLST) antibiotic susceptibility testing. Overall, prevalence of cerebrospinal fluid (CSF) 1.7%, blood 0.2%, 15.3%. The multiple drug resistance among 48.6%, while percentage various...
Pneumococcal carriage is the precursor for development of pneumococcal disease, and also responsible transmission organism from person-to-person. In Africa, little known about pneumococcus in relation to people with HIV infection. The aim study was investigate epidemiology among infected children visiting a tertiary hospital Ghana, including prevalence, risk factors serotype distribution.This cross sectional carried out February May, 2015 at Paediatric Clinic Korle-Bu Teaching Hospital...
Cerebral palsy (CP) is a lifelong neurodevelopmental condition caused by injury to the developing fetal or infant brain. In developed countries 75% 80% of cases are as result prenatal brain injury. Data from limited; however, higher proportion affected children may have perinatal postnatal The objectives were …
To compare neurological functioning of neonates born to mothers with and without malaria in pregnancy.Pregnant women presenting at Korle Bu Teaching Hospital, Ghana were recruited into this prospective observational study. Malaria exposure was determined by clinically documented antenatal infection; parasitemia maternal, placental, or umbilical cord blood; placental histology. Neurological assessed using the Hammersmith Neonatal Examination within 48 hours birth. Performance classified as...
Since its discovery in 1891, the pneumococcus has been one of most extensively studied microbes, and was involved several historical findings such as genetic material that later shown to be DNA. The is part normal bacterial flora nasopharynx, but can on occasions progress sterile sites body cause invasive diseases. There are about million new pneumococcal infections every year, majority which occur developing world where children
Background . Plasmodium falciparum malaria, as well certain antimalarial drugs, is associated with hearing impairment in adults. There little information, however, on the extent, if any, of this effect children, and evidence linking artemisinin combination therapies (ACTs) inconclusive. Methods Audiometry was conducted children uncomplicated malaria treated artesunate-amodiaquine (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background: Micronutrients such as coper, zinc and selenium are essential to the functioning of nervous system their deficiencies is a critical concern for cerebral palsy children. The aim this study was investigate micronutrient levels antioxidant status in pediatric patients compare them neurologically normal children Accra, Ghana. Method: Twenty seven with (0-14 years) 17 age-bracket matched neurological controls were recruited. Three milliliters venous blood drawn from each participant...
Despite the high mortality, pneumonia retains a relatively low profile among researchers, funders and policymakers. Here we reflect on problems priorities of in Ghana, briefly review evidence base upon in-person discussions between Southampton-based authors MGH JB academic, clinical policy colleagues Ghana. The took place Accra August 2017.
Child abuse affects millions of children globally. Comprehensive training is essential to promote its recognition and trigger appropriate responses prevent missed opportunities for intervention. We describe a child protection programme University Ghana Medical School students the cross-sectional survey student assessment at end. The comprised lectures, dissertations, community surveys, case reports, public health advocacy topics, poster designs. These were carried out as part regular...
Introduction: Convulsions associated with fever and acute onset of unknown aetiology case fatalities have become a long observed medical condition at the Child Health Department Korle-Bu Teaching Hospital. Children admitted to department seizures undetermined origin has been source diagnostic confusion. Studies from Asia Pacific region suggest link non-polio enteroviruses. The aim study was investigate association between enterovirus encephalopathy causing neurological morbidity in children.