A5070154989- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Reproductive Biology and Fertility
- Williams Syndrome Research
- Assisted Reproductive Technology and Twin Pregnancy
- Genomics and Rare Diseases
- RNA regulation and disease
- Reproductive System and Pregnancy
- Carcinogens and Genotoxicity Assessment
- Pelvic floor disorders treatments
- Effects and risks of endocrine disrupting chemicals
- Cardiac, Anesthesia and Surgical Outcomes
- Pregnancy-related medical research
- Anorectal Disease Treatments and Outcomes
- Memory and Neural Mechanisms
- Gynecological conditions and treatments
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Congenital Ear and Nasal Anomalies
- Dementia and Cognitive Impairment Research
- Maternal and fetal healthcare
- Nuclear Receptors and Signaling
- Ectopic Pregnancy Diagnosis and Management
- Enhanced Recovery After Surgery
- Metabolism and Genetic Disorders
Cairo University
2018-2024
National Research Centre
2018-2024
Agricultural Genetic Engineering Research Institute
2023
National Institute of Health
2020
Kiel University
2019
Abstract Rubinstein–Taybi syndrome (RSTS) is an autosomal dominant disorder, caused by loss‐of‐function variants in CREBBP or EP300 . Affected individuals present with distinctive craniofacial features, broad thumbs and/or halluces, and intellectual disability. RSTS phenotype has been well characterized of European descent but not other populations. In this study, from diverse populations were assessed clinical examination facial analysis technology. Clinical data 38 14 different countries...
Turner syndrome (TS) is a common multiple congenital anomaly resulting from complete or partial absence of the second X chromosome. In this study, we explore phenotype TS in diverse populations using clinical examination and facial analysis technology. Clinical data 78 individuals images 108 with 19 different countries were analyzed. Individuals grouped into categories African descent (African), Asian, Latin American, Caucasian (European descent), Middle Eastern. The most features across all...
Abstract Objective Postnatal scanty milk secretion is a common complaint. Some physical and medical interventions were advocated to help production. These should be effective safe for the mother infant. This study aimed compare effects of low-level laser therapy electroacupuncture on postnatal secretion. Study Design A randomized controlled conducted 60 healthy primiparous mothers with insufficient lactation. They randomly divided into three equal groups: group (control), B (those who...
Genetics and Genomic Medicine in Egypt: steady pace. Egypt is a Mediterranean North African country (Fig. 1). It the third-most densely inhabited on continent after Nigeria Ethiopia. The total number of Egyptian population estimated to be 92 million, 2016 (Central Agency for Public Mobilization Statistics Egypt). About 95% live sides Nile banks, Delta, along Suez Canal. Small communities spread throughout desert regions clustered around oases. Both strategic position its natural resources...
Objective: The main aim of this study is to evaluate the micronuclei scoring as a biomarker for early detection and screening genotoxic effect cigarette smoking in peripheral blood T- lymphocytes. Methods: A total number eligible 148 individuals have participated study; 78 Current smokers 70 never smokers. Cytokinesis-block micronucleus assay was performed all participants T-lymphocytes. Assessment status conducted through detailed history, Fagerström test nicotine dependence (FTND) scoring,...
Background: Unexplained infertility is a rising problem and endometrial manipulation could be one of the solutions for enhancing pregnancy rate live birth in such circumstances.Aims: To evaluate influence local physical with specializd method tubal hydration (Elgazzar Alalfy technique) on ICSI outcome increasing chemical, clinical, after previous recurrent failure patients unexplained infertility.Results: When comparing group 1 (hydrotubation group) 2 (the control no intervention) regards to...
Abstract Background In vitro fertilization (IVF) has revolutionized human reproduction. Originally designed to assist couples who are unable conceive, the clinical applications of IVF have significantly broadened encompass many medical and genetic disorders, as well fertility maintenance. The poor ovarian response is a very challenging issue in field infertility, “double triggering” combines single bolus gonadotropic releasing hormone (GnRH)-agonist with standard dosage chorionic...
Introduction Postpartum hemorrhage that occurs frequently with placenta previa is one of the causes maternal mortality in 14% developing countries.Objective To assess efficacy cervical inversion as a tamponade controlling bed cases previa.Patients and method A prospective randomized controlled study was conducted among total 240 pregnant women (120 subjected to Alalfy modified technique plus hemostatic sutures 120 not only Obstetrics Gynecology Department at Suez Canal University hospital,...
BackgroundAlthough C-section sometimes lifesaving but it has many complications, one of these complications is ileus which temporary inhibition gastrointestinal function, it's treatment supportive by gastric decompression, together with IV hydration and correction electrolyte abnormalities discontinuation anti-kinetic drugs. 1 The retrieval full bowel movement occurs within seventy two hours post in uncomplicated cases. 2 While cases that impaired functional ability more than 3 days, this...
Background/aim About one-fifth of cancer deaths are caused by tobacco smoking. Nicotine-related DNA damage is thought to be the result oxidative stress, whereas can represented in form binucleated micronuclei (BMNi). The aim this study determine relationship between stress biomarkers and scoring nicotine-dependent smokers. Subjects methods present enrolled 112 Egyptian male participants, which 45 smokers matched with 67 nonsmokers. All participants have been clinically evaluated investigated...
Introduction Phenotypically normal adults presenting with a history of viable aneuploidy offspring or without spontaneous abortion may have tendency for nondisjunction in both somatic cells during mitosis and gametes meiosis which results these distressing outcomes. This from abnormal performance centromere function presents the form increased percentage premature separation (PCS) acquired parental aneuploidy. study aimed to investigate feasibility PCS as biomarkers screening parents...
Monosomy 1p36 syndrome is one of the most common submicroscopic deletion syndromes, which characterized by presence delayed developmental milestones, intellectual disability, and clinically recognizable dysmorphic craniofacial features. The comprises 4 cytogenetic groups including pure terminal deletions, interstitial complex rearrangements, derivative chromosomes 1 due to unbalanced translocations, where translocations represent least percentage all cases monosomy (7%). Most patients with...
Abstract Background Alzheimer’s disease (AD) is the most widely recognized type of dementia. It associated with cell cycle abnormalities including genomic instability and increased micronuclei (MNi) which usually evolve many years before appearance clinical manifestations. Digital electroencephalogram (EEG) has a role in perceiving brain changes dementia early detection cognitive decline. This study aimed to assess competency using neurophysiological markers absolute power alpha waves...
Several neurological disorders, neurodevelopmental and neurodegenerative disorders have a genetic element with various clinical presentations ranging from mild to severe presentation. Neurological are rare multifactorial characterized by dysfunction degeneration of synapses, neurons, glial cells which essential for movement, coordination, muscle strength, sensation, cognition. The cerebellum might be involved at any time, either during development maturation or later in life. Herein, we...
Objective: To investigate the effects of body mass index (BMI) husband and wife on neonatal weight clinical outcome in intracytoplasmic sperm injection (ICSI) cycles. Methods:A Prospective cohort study that was conducted patients undergoing ICSI cycle from February 2016 to March 2018. Results: By investigating various factors by linear regression analysis only femaleBMI GA at delivery (p value <0.001) had statistically significant increasing impact, while pregnancy number decreasing impact...
Background Recurrent spontaneous abortion (RSA) is a common challenging reproductive problem, whereas the frequency of chromosomal abnormalities among couples with RSA varies from 2 to 8%. Chromosomal heteromorphisms that have been considered as normal variants are suspected clinical effect in form infertility or RSA. Objective The objective this research study role and incidence different types findings including aberrations results can add genetic counseling well serve step for collecting...
We aimed to evaluate the efficacy of topical estrogen after transvaginal tension-free vaginal tape-obturator (TVT-O) in treatment