A5072008008- Pneumonia and Respiratory Infections
- Antibiotic Resistance in Bacteria
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Urinary Tract Infections Management
- Bacterial Infections and Vaccines
- Bacterial biofilms and quorum sensing
- Vibrio bacteria research studies
- Essential Oils and Antimicrobial Activity
- Global Maternal and Child Health
- Pharmaceutical and Antibiotic Environmental Impacts
- Malaria Research and Control
- Tuberculosis Research and Epidemiology
- Streptococcal Infections and Treatments
- Oral microbiology and periodontitis research
- Antifungal resistance and susceptibility
- Neonatal and Maternal Infections
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Parasites and Host Interactions
- Wound Healing and Treatments
- Papaya Research and Applications
Korle Bu Teaching Hospital
2019-2024
University of Ghana
2013-2024
University of Health and Allied Sciences
2017-2019
University of Copenhagen
2013-2015
University of Bahrain
2010
Antimicrobial resistance (AMR) in Gram-negative bacteria-causing bloodstream infections (BSIs), such as Klebsiella pneumoniae and non-typhoidal Salmonella (NTS), is a major public health concern. Nonetheless, AMR surveillance remains scarce sub-Saharan Africa, where BSI treatment largely empirical. The aim of the study was to determine distribution patterns BSI-causing NTS, K. pneumoniae, other bacteria Ghana.A cross-sectional conducted between April December 2021 at eleven sentinel...
Aim To describe the occurrence of carbapenem resistance among multidrug-resistant (MDR) Escherichia coli and Klebsiella pneumoniae isolated from clinical specimens in Accra using phenotypic genotypic methods. Methodology The study was cross-sectional, involving 144 MDR E . K isolates recovered Central Laboratory Korle Bu Teaching Hospital (KBTH). were re-cultured bacteriologically, identified standard biochemical tests, subjected to antibiotic susceptibility testing Kirby-Bauer method....
Beta-lactamase (β-lactamase)-producing Gram-negative bacteria (GNB) are of public health concern due to their resistance routine antimicrobials. We investigated the antimicrobial and occurrence carbapenemases, extended-spectrum β-lactamases (ESBLs) AmpCs among GNB from clinical sources. were identified using matrix-assisted laser desorption/ionization time flight-mass spectrometry (MALDITOF-MS). Antimicrobial susceptibility testing was performed via Kirby-Bauer disk diffusion a microscan...
Following advances in DNA and protein sequencing, the application of computational approaches analysing biological data has become a very important aspect biology. Evaluating similarities between sequences is crucial to our understanding evolutionary biology, this can be achieved by basic local alignment search tool (BLAST) fast (FASTA). BLAST FASTA have fundamental tools biology it essential know how they operate, task accomplish accurately interpret their output. This paper provides an...
Background: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases encountered in clinical practice, and accounts for significant morbidity high medical costs. To reduce its public health burden, there need local research data to address aspects prevention management UTI. The aim this study was investigate community-acquired UTI among adults Accra, Ghana, including risk factors, etiological agents, antibiotic resistance. Methods: This a cross-sectional...
Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data required to understand the local drivers antimicrobial and support decision-making processes including implementation appropriate stewardship strategies.To measure usage in hospitals Ghana.Using Global Point Prevalence instruments processes, we conducted point prevalence surveys across AMR surveillance sentinel Ghana, between September December 2019. Hospital records all inpatients on admission at 0800 hours...
Antimicrobial resistance (AMR) is one of the top 10 public health threats. One approach to tackling AMR menace could involve expanding range surveillance domains include hospital wastewater (HWW), a domain that has largely been overlooked by researchers.To evaluate occurrence multidrug-resistant bacteria in Korle Bu Teaching Hospital (KBTH).This was longitudinal study involving 288 HWW samples consecutively collected across 12 weeks from pool emanating 2 critical care units KBTH-The Child...
Abstract Background The objective of this study was to determine the prevalence nasopharyngeal carriage, serotype distribution, and penicillin resistance Streptococcus pneumoniae in children ≤6 years age Ghana. Methods A cross-sectional carried out on a cluster-randomized sample attending nurseries kindergartens Accra Tamale, Basic data age, sex exposure antimicrobials previous month were collected all subjects. Nasopharyngeal swabs obtained from participants pneumococcal isolates...
Methicillin-resistant Staphylococcus aureus (MRSA) poses a public health threat owing to its extensive resistance antibiotics, association with persistent outbreaks, and markedly increased healthcare costs. Moreover, HIV-infected individuals are at greater risk for colonization MRSA, may act as reservoirs subsequent transmission other individuals. In Ghana, little is known about MRSA in relation at-risk populations, such children. The aim of this study was investigate nasal carriage S. among...
Nasopharyngeal carriage of aerobic Gram-negative bacilli (GNB) may precede the development invasive respiratory infections. We assessed prevalence nasopharyngeal GNB and their antimicrobial resistance patterns among healthy under-five children attending seven selected day-care centres in Accra metropolis Greater region Ghana from September to December 2016. This cross-sectional study analysed a total 410 frozen samples for drug resistance. The was 13.9% (95% CI: 10.8–17.6%). most common were...
The aim of this study was to determine the prevalence Streptococcus agalactiae (group B streptococci, GBS) among healthy, pregnant women attending antenatal care at different sites in Greater Accra Region, Ghana.Between 2010 and June 2013, recto-vaginal swab samples were collected from two southern Ghana. within 35 37 weeks gestation period. These inoculated into Todd-Hewitt broth followed by sub-culturing onto a sheep-blood agar plate. Identification performed on single subcultured colony....
Aim: This study investigated the spectrum of bacteria infecting ulcers individuals with diabetes at Korle Bu Teaching Hospital in Accra, Ghana, focusing on Staphylococcus aureus (S. aureus) and methicillin-resistant S. (MRSA), respect to their prevalence, factors predisposing infection ulcers, antimicrobial resistance patterns. Methodology: cross-sectional was conducted The Ulcer Clinic, Department Surgery, Hospital, involving 100 diabetic foot ulcer patients. each participant swabbed...
Introduction: Infants are at risk of Staphylococcus aureus (S. aureus) colonization and infection. The aim this study was to investigate S. methicillin-resistant (MRSA) among infants, including the prevalence, predictors colonization, antibiogram.
 Methodology: cross-sectional, involved infants aged less than one year recruited Princess Marie Louise Children’s Hospital in Accra, Ghana. Sociodemographic clinical data participants were gathered with a structured questionnaire. Nasal swabs...
This study was carried out primarily to evaluate the public health burden related Streptococcus pneumoniae in Ghana and provide preliminary molecular epidemiological data on organism. Invasive nasopharyngeal specimens were screened for S. pneumoniae, isolates subjected serotyping, multilocus sequence typing (MLST) antibiotic susceptibility testing. Overall, prevalence of cerebrospinal fluid (CSF) 1.7%, blood 0.2%, 15.3%. The multiple drug resistance among 48.6%, while percentage various...
Background Pneumococcal carriage is the precursor for development of pneumococcal disease, and also responsible transmission organism from person-to-person. Individuals with Sickle Cell Disease (SCD) are more likely to develop invasive disease S. pneumoniae compared their healthy counterparts presentation in former usually abrupt severe. In Africa, little known about pneumococcus relation people SCD (SCD). The aim study was investigate epidemiology among patients including prevalence, risk...
The study objective was to determine the carriage and serotype distribution of Streptococcus pneumoniae among children in Accra, Ghana, five years after introduction pneumococcal conjugate vaccine (PCV-13) 2012. Nasopharyngeal swab samples were collected from 410 below 5 age September December, 2016. Pneumococcal isolates identified by optochin sensitivity bile solubility. Serotyping performed using latex agglutination kit Quellung reaction. furthermore tested for antimicrobial...
This cross-sectional study investigated the Staphylococcus aureus (S. aureus) and methicillin-resistant S. (MRSA) nasopharyngeal carriage epidemiology in Accra approximately five years post-pneumococcal conjugate vaccines introduction country. Archived swabs collected from 410 children aged under old were bacteriologically cultured. The resultant isolates subjected to antimicrobial susceptibility testing screening for of mecA LukF-PV (pvl) genes, following standard procedures. data obtained...
Background: Efforts to combat antimicrobial resistance (AMR) should be based on the One Health approach, involving human health, animal and environment. In Ghana, previous studies AMR have given little attention source food, a major route of transmission antibiotic-resistant zoonotic pathogens. The aim this study was investigate occurrence multidrug-resistant (MDR) bacteria in meat sold Accra. Methods: This cross-sectional which 270 samples (90 each beef, goat meat, chicken) were collected,...
Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it candidate for structural modification. Thus, this study incorporated triazole moiety on thymol and chlorination of to help improve its potency.