A5058643036- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Berberine and alkaloids research
- Pharmacogenetics and Drug Metabolism
- Plant chemical constituents analysis
- Connexins and lens biology
- Synthesis and biological activity
- Spectroscopy Techniques in Biomedical and Chemical Research
- Genomics, phytochemicals, and oxidative stress
- Biochemical effects in animals
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Sesquiterpenes and Asteraceae Studies
- Transgenic Plants and Applications
- Wound Healing and Treatments
- Advanced Glycation End Products research
- Pharmacological Effects of Natural Compounds
- Computational Drug Discovery Methods
- Natural product bioactivities and synthesis
- Diabetic Foot Ulcer Assessment and Management
- Vanadium and Halogenation Chemistry
- Medicinal plant effects and applications
- Lichen and fungal ecology
- Mangiferin and Mango Extracts
- Toxin Mechanisms and Immunotoxins
University of Cape Coast
2020-2024
International Centre of Insect Physiology and Ecology
2022
Thymol, a natural monoterpene phenol is not only relevant clinically as an anti-microbial, anti-oxidant and anti-inflammatory agent but also holds the prospect template for pharmaceutical semi-synthesis of therapeutic agents. It major component essential oils from many plants. Evidence abound linking overall bioactivity thymol to its nucleus, specifically, hydroxyl (-OH) substituent on carbon number one (C1) nucleus. Other studies have posited that substantially altered by chemical...
Thymol as a natural biological template can be modified chemically since the hydroxyl group makes it candidate for structural modification. Thus, this study incorporated triazole moiety on thymol and chlorination of to help improve its potency.
Despite the enrollment of new small molecules such as Sorafenib for treatment hepatocellular carcinoma (HCC), HCC still remains a significant contributor to cancer-related mortality and morbidity globally. Zanthoxylum zanthoxyloides is long suspected possessing anticancer bioactive compounds that may hold prospect adjunctive therapy against inflammation-related cancers HCC.This study assessed effects an alkaloidal extract leaves on CCl4/olive oil (1 : 1 v/v)-induced HCC-like phenotypes in...
Parkia clappertoniana Keay (Family: Fabaceae) (P. clappertoniana) fruit husk is commonly used in northern Ghana for wound treatment. However, this folk claim remains to be confirmed scientifically.This study investigated healing and antimicrobial effects of P. extract (PCFHE) by using excision model rats.After preparation phytochemical analysis PCFHE, it was reconstituted purified water emulsifying ointment yielding a formula (0.3, 1, 3%). Excision wounds were established healthy male...
This study assessed the prophylactic anti-HCC effects of a combined stem and root alkaloidal extract
The use of Aspilia africana in traditional medicine for the management ocular diseases has been reported India and some indigenous communities Africa. aim this study was to investigate aqueous extract flowers A. (AAE) as an anticataract remedy using murine models diabetic senile cataracts.Preliminary phytochemical screening extract, vitro antioxidant assays, aldose reductase inhibitory activity were performed. For investigations extracts, cataract induced by galactose administration...
Background: Thymol as a natural biologically template can be modified chemically since the hydroxyl group makes it candidate for structural modification. Thus, this study incorporated triazole moiety on thymol and chlorination of to help improve its biological potency.Materials Methods: A series ten 1,2,3-triazole-thymol derivatives 1-10 were synthesized from thymol, by click reaction between O-propargyl terminal alkyne chlorothymol with benzyl azide substituted azides. Their structures...
In Africa, Alstonia boonei is used folklorically for the management of multitude conditions including cataract, which accounts 50% cases blindness in region. The current study set out to probe traditional use aqueous extract stem bark (ABE) as an anticataract remedy using Sprague Dawley rat models. We investigated probable phytochemical constituents extract, vitro antioxidant potential, and its aldose reductase inhibition. For investigations, diabetic cataract was induced galactose...