A5065048488- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Prenatal Screening and Diagnostics
- Blood donation and transfusion practices
- Pregnancy and preeclampsia studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Blood groups and transfusion
- Chronic Myeloid Leukemia Treatments
- Systemic Lupus Erythematosus Research
- Venous Thromboembolism Diagnosis and Management
- Bone and Joint Diseases
- Blood properties and coagulation
- Pneumocystis jirovecii pneumonia detection and treatment
- Central Venous Catheters and Hemodialysis
- Hepatitis B Virus Studies
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- Global Maternal and Child Health
University of Ghana
2016-2025
Korle Bu Teaching Hospital
2012-2023
UniMAC-GIJ
2020
University of Health and Allied Sciences
2016-2019
University of Benin
2009
Olabisi Onabanjo University
2005-2007
University of Benin Teaching Hospital
2007
Obafemi Awolowo University
2006
In Africa, sickle cell disease (SCD) is a major public health problem with over 200,000 babies born per year. Ghana, approximately 15,000 (2%) of Ghanaian newborns are diagnosed SCD annually. A retrospective review medical records all patients aged 13 years and above, who presented to the clinic at Ghana Institute Clinical Genetics (GICG), Korle-Bu, from 1st January 2013 31st December 2014, was carried out, using data abstraction instrument document their phenotypes, demographics,...
Sickle cell disease (SCD) is associated with adverse pregnancy outcome. In women SCD living in low-resource settings, significantly increased maternal and perinatal mortality rates. We tested the hypothesis that implementing a multidisciplinary obstetric hematology care team setting would reduce conducted before-and-after study, at Korle-Bu Teaching Hospital Accra, Ghana, to evaluate effect of obstetric-hematology for combined SCD-Obstetric Clinic. The pre-intervention period was assessed...
Sickle cell hemoglobin SC (HbSC) disease is the second most frequent sickle (SCD) genotype after anemia (HbSS). Globally, ∼55 000 newborns with HbSC are delivered annually, highest HbC gene frequency in West Africa. In Ghana, 40% of adults visiting Ghana Institute Clinical Genetics SCD clinic have HbSC. Unlike HbSS, hydroxyurea use not routinely recommended for individuals because perceived high-risk to benefit ratio. To test hypothesis that at least 5% will meet American Society Hematology...
Laboratory request forms provide information about the laboratory test being requested for. They carry demographic data and other such as location of patient, number, doctor's name, signature doctor, telephone number requesting doctor. Omission on may lead to errors. The aim this study was evaluate level completion at haematology department a Ghanaian tertiary hospital.Three thousand submitted between January April 2010 were retrieved studied. provided each form recorded in spread sheet...
In Africa, the maternal mortality rate in sickle cell disease (SCD) is ~10%. Our team previously demonstrated an 89% decrease a before-and-after feasibility study among women with SCD living low-resource setting Ghana. same cohort including additional participants and without SCD, we used prospective design to test hypothesis that implementing multidisciplinary care for pregnant will result similar perinatal rates compared SCD. We prospectively enrolled or trait followed them up 6-week...
Individuals with sickle cell disease particularly the homozygous (SS) genotype historically have relatively low blood pressure. Nonetheless, they develop vasculopathy-associated organ dysfunction and risk of increases at pressures that are normal in general population. This phenomenon is termed relative systemic hypertension (RSH) a systolic pressure range 120–139 mmHg, diastolic 70–89 mmHg. The significance RSH lies its association renal insufficiency, pulmonary hypertension, stroke...
Background Pneumococcal carriage is the precursor for development of pneumococcal disease, and also responsible transmission organism from person-to-person. Individuals with Sickle Cell Disease (SCD) are more likely to develop invasive disease S. pneumoniae compared their healthy counterparts presentation in former usually abrupt severe. In Africa, little known about pneumococcus relation people SCD (SCD). The aim study was investigate epidemiology among patients including prevalence, risk...
Objectives To provide lay information about genetics and sickle cell disease (SCD) to identify address ethical issues concerning the Sickle Cell Disease Genomics of Africa Network covering autonomy research decision-making, risk SCD complications organ damage, returning genomic findings, biorepository, data sharing, healthcare provision for patients with SCD. Design Focus groups using qualitative methods. Setting Six cities in Ghana, Nigeria Tanzania within communities secondary care....
The prevalence of anemia in HIV/AIDS patients is high, with a multitude possible etiologies; autoimmune hemolytic (AIHA) has been associated poor prognosis when treated red cell transfusion. Our aim was to demonstrate the frequency AIHA cohort adult Nigerian and see if presence or not related severity disease regards CD4 counts absence opportunistic infections.Ninety- eight HIV infection were screened for using packed volume (PCV), direct antiglobulin test (DAT) reticulocyte count (RC).The...
In a prospective study using standard methods, haemorheological parameters were assessed in 10 sickle cell anaemia patients pain crises. Patients investigated for possible changes determinants of rheology the course painful episodes: blood samples taken plasma fibrinogen concentration (PFC); viscosity (PV); haematocrit (Hct), whole (WBV) and erythrocyte sedimentation rate (ESR) methods. Samples collected on presentation to emergency unit daily 4 consecutive days. Whole significantly higher...
Cancer-associated venous thromboembolism (CAT) has detrimental impact on patients' clinical outcomes and quality of life. Data CAT education, communication, awareness among the general cancer population are scanty.We present preliminary results an ongoing patient-centered survey including 27 items covering major spheres CAT. The survey, available in 14 languages, was promoted disseminated online through social networks, email newsletters, websites, media.As September 20, 2022, 749...
Sickle cell disease (SCD) poses a significant health burden globally, particularly in Africa, where prevalence rates are notably high.Hydroxyurea has emerged as promising therapeutic agent for managing SCD, yet its effects on clinical outcomes the Ghanaian context remain understudied.This retrospective study aimed to investigate changes and haematological parameters associated with hydroxyurea use adolescents adult patients living sickle disease.A three-level review was conducted among 105...
Warfarin is a widely prescribed anticoagulant with narrow therapeutic window for thromboembolic events. displays large individual variability in dose requirements. The purpose of this study to assess the contribution patient-specific and genetic risk factors requirements patients on either high or low warfarin maintenance Ghana. Blood samples were collected from 141 (62 males, 79 females) Ghanaian stable determine their INR. Influence patient specific gene variations within VKORC1, CYP2C9...
Abstract Background The supply of blood in many low‐ and middle‐income nations Sub‐Saharan Africa (SSA) does not meet the patient care needs. Lack delay transfusion cause harm to patients slow rate progress other parts health system. Recognizing power implementation science, BLOODSAFE Program was initiated which supports three SSA research study teams one data coordinating center (DCC) with goal improve access safe SSA. Study Design Methods team Ghana is focusing on studying decreasing iron...