A5017265811- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Global Maternal and Child Health
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Urinary Tract Infections Management
- Neonatal and Maternal Infections
- Vibrio bacteria research studies
- Pharmaceutical and Antibiotic Environmental Impacts
- Identification and Quantification in Food
- Pharmaceutical Practices and Patient Outcomes
- Bacterial biofilms and quorum sensing
- Patient Satisfaction in Healthcare
- Streptococcal Infections and Treatments
- Sepsis Diagnosis and Treatment
- Medication Adherence and Compliance
- Child Nutrition and Water Access
- Salmonella and Campylobacter epidemiology
- Pediatric Urology and Nephrology Studies
- Insect symbiosis and bacterial influences
- Insects and Parasite Interactions
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Aquaculture disease management and microbiota
- Fecal contamination and water quality
Ghana Health Service
2021-2023
Korle Bu Teaching Hospital
2014-2023
University of Ghana
2020-2023
University of Copenhagen
2020-2021
Rigshospitalet
2020-2021
Copenhagen University Hospital
2020-2021
Antimicrobial resistance (AMR) remains an important global public health issue with antimicrobial misuse and overuse being one of the main drivers. The Global Point Prevalence Survey (G-PPS) Consumption Resistance assesses prevalence quality prescriptions across hospitals globally. G-PPS was carried out at 17 Ghana, Uganda, Zambia Tanzania. overall use 50% (30–57%), most antibiotics prescribed belonging to WHO ‘Access’ ‘Watch’ categories. No ‘Reserve’ category study sites while...
Bloodstream infections (BSI) are life-threatening emergencies. Identification of the common pathogens and their susceptibility patterns is necessary for timely empirical intervention. We conducted a 4-year retrospective analysis blood cultures from all patients excluding neonates at Korle-Bu Teaching hospital, Ghana, January 2010 through December 2013. Laboratory report data were used to determine BSI, culture contamination, pathogen profile, antimicrobial resistance patterns. Overall, 3633...
Despite the clinical significance of Salmonella infections, surveillance data worldwide remains limited and is more so exemplified by lack reports from Africa especially in eastern, central western Africa. This study on serotypes as significant causes blood stream infections (BSI) multidrug antibiotic resistance at Korle-Bu Teaching Hospital Accra, Ghana. Antibiogram patterns, seasonal variations disease incidence predisposing factors for infection with were analyzed retrospectively over a...
This study was designed to investigate whether household cockroaches harbor cephalosporin-resistant enterobacteria that share resistance determinants with human inhabitants. From February through July 2016, whole cockroach homogenates and fecal samples from 100 households were cultured for (CRe). The CRe examined plasmid-mediated AmpC, ESBL, carbapenemase genes; antibiotic susceptibility patterns; conjugative transfer of mechanisms. Clonal associations between determined by multi-locus...
Carriage of multidrug resistant (MDR) Gram-negative bacteria (GN) in hospitalized neonates may increase the risk difficult-to-treat invasive infections at neonatal intensive care units (NICUs). Data on MDRGN carriage among newborns Africa are limited.We conducted a cross-sectional study NICUs 2 tertiary hospitals Ghana. Swabs from axilla, groin, perianal region, and environment were cultured, GN identified, antibiotic susceptibility was tested. We obtained blood culture isolates with sepsis....
Background: Urinary tract infection (UTI) is one of the most common bacterial infectious diseases encountered in clinical practice, and accounts for significant morbidity high medical costs. To reduce its public health burden, there need local research data to address aspects prevention management UTI. The aim this study was investigate community-acquired UTI among adults Accra, Ghana, including risk factors, etiological agents, antibiotic resistance. Methods: This a cross-sectional...
Infections by Extended-Spectrum Beta-Lactamase producing Escherichia coli (ESBL-Ec) are on the increase in Ghana, but level of environmental contamination with this organism, which may contribute to growing Antimicrobial Resistance (AMR), is unknown. Using WHO OneHealth Tricycle Protocol, we investigated E. (Ec) and ESBL-Ec two rivers Ghana (Odaw Accra Okurudu Kasoa) that receive effluents from human animal wastewater hotspots over a 12-month period. Concentrations Ec, percent ESBL-Ec/Ec...
Antimicrobial resistance (AMR) is a public health crisis of global proportions. Data required to understand the local drivers antimicrobial and support decision-making processes including implementation appropriate stewardship strategies.To measure usage in hospitals Ghana.Using Global Point Prevalence instruments processes, we conducted point prevalence surveys across AMR surveillance sentinel Ghana, between September December 2019. Hospital records all inpatients on admission at 0800 hours...
Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and frequently resistant to third-generation cephalosporin antibiotics. Although resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. We aimed measure effects associated with cephalosporins hospitalised patients infection Africa.
Management of urinary tract infections is challenged by increasing antimicrobial resistance (AMR) worldwide. In this study, we describe the trends in uropathogens isolated from largest private sector laboratory Ghana over a five-year period. We reviewed positive urine cultures at MDS Lancet Laboratories 2017 to 2021. The proportions with oral and parenteral antimicrobials recommended standard treatment guidelines were determined. proportion multi-drug resistant isolates, ESBL...
There is limited data to guide the prevention and management of surgical site infections (SSI) in low- middle-income countries. We prospectively studied aetiological agents associated with SSI their corresponding antibiotic susceptibility patterns a tertiary hospital Ghana.
Nasopharyngeal carriage of aerobic Gram-negative bacilli (GNB) may precede the development invasive respiratory infections. We assessed prevalence nasopharyngeal GNB and their antimicrobial resistance patterns among healthy under-five children attending seven selected day-care centres in Accra metropolis Greater region Ghana from September to December 2016. This cross-sectional study analysed a total 410 frozen samples for drug resistance. The was 13.9% (95% CI: 10.8–17.6%). most common were...
The aim of this study was to evaluate the attributable patient cost antimicrobial resistance (AMR) in Ghana provide empirical evidence make a case for improved AMR preventive strategies hospitals and general population.A prospective parallel cohort design which participants were enrolled at time hospital admission remained until 30 days after diagnosis bacteraemia or discharge from hospital/death. Patients matched on age group (± 5 years patients), treatment ward, sex, type. included all...
Abstract We sequenced 29 carbapenemase-producing Klebsiella pneumoniae isolates from a neonatal intensive care unit in Ghana. Twenty-eight were sequence type 17 with blaOXA-181 and differed by 0–32 single-nucleotide polymorphisms. Improved surveillance infection control are needed to characterize curb the spread of multidrug-resistant organisms sub-Saharan Africa.
Wastewater treatment plants receive sewage containing high concentrations of bacteria and antibiotics. We assessed bacterial counts their antibiotic resistance patterns in water from (a) influents effluents the Legon plant (STP) Accra, Ghana (b) upstream, outfall, downstream recipient Onyasia stream. conducted a cross-sectional study quality-controlled testing (January–June 2018). In STP effluents, mean (colony-forming units/100 mL) had reduced E. coli (99.9% reduction; 102,266,667 to 710),...
With safely managed water accessible to only 19% of the population in Ghana, majority its residents are at risk drinking contaminated water. Furthermore, this could be a potential vehicle for transmission antimicrobial-resistant bacteria. This study assessed presence bacteria and antibiotic resistance profile Escherichia coli Pseudomonas aeruginosa drinking-water sources using membrane filtration Kirby-Bauer disc diffusion methods. A total 524 samples were analyzed coliforms, heterotrophic...
The aim of this study was to investigate urinary tract infections among patients with Bladder Outlet Obstruction (BOO) at the Korle Bu Teaching Hospital (KBTH) in Accra, Ghana, including prevalence, risk factors, aetiological agents and their antibiogram. Urine specimens were collected from 188 male presenting BOO cultured for bacteria. bacterial isolates identified using standard microbiological methods tested against a spectrum antimicrobial Kirby Bauer method. Demographic information...
Background: Bloodstream infections (BSIs) are a major cause of morbidity and mortality in hospitalized neonates. Data on antibiotic resistance neonatal BSIs their impact clinical outcomes Africa limited. Methods: We conducted prospective cohort study at 2 tertiary level intensive care units (NICUs) Ghana. All neonates admitted to the NICUs were included from October 2017 September 2019. monitored BSI rates analyzed effect duration hospitalization. Results: Of 5433 included, 3514 had least...
Surveillance of hospital antibiotic consumption provides data to inform corrective action and for monitoring antimicrobial stewardship activities. This study described patterns from 2016 through 2021 at a secondary healthcare facility in Ghana.Using the WHO methodology surveillance hospitals, we analysed 6-year pharmacy issue Eastern Regional Hospital. We report on defined daily dose (DDD) per 100 patients, types antibiotics consumed according Anatomic Therapeutic Classification (ATC), AWaRe...
Management of urinary tract infection is challenged by increasing antimicrobial re-sistance (AMR) worldwide. In this study we describe the trends in uropathogens isolated from largest private sector laboratory Ghana over a five-year period. We reviewed positive urine cultures at MDS Lancet Laboratories 2017 to 2021. Proportions with resistance oral and parenteral antimicrobials recommended standard treatment guidelines were determined. The proportion multi-drug resistant isolates, ESBL...
There is little published information on antimicrobial resistance (AMR) in animals Ghana. We determined the prevalence and factors associated with AMR, multi-drug (MDR-resistance to ≥3 classes) colistin Enterobacteriaceae healthy pigs Accra, Rectal swabs obtained from 20 farms January March 2022, were examined for Escherichia coli, Enterobacter spp. Klebsiella pneumoniae. AMR was using standard microbiological techniques mcr-1 gene detected through molecular analysis. isolated 197 of 200...
<ns4:p><ns4:bold>Background:</ns4:bold> Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation circumstances for management such resistant a group African public-sector hospitals participating major research study.</ns4:p><ns4:p> <ns4:bold>Methods: </ns4:bold>We gathered data from eight across sub-Saharan Africa hospital services, infection prevention antibiotic...
Abstract Understanding the healthcare provider costs of antimicrobial resistance (AMR) in lower-middle-income countries would motivate facilities to prioritize reducing AMR burden. This study evaluates extra length stay and associated due estimate potential economic benefits prevention strategies. We combined data from a parallel cohort with administrative participating hospitals. The prospectively matched patients bloodstream infections caused by third-generation cephalosporin-resistant...
Bloodstream infections (BSI) caused by Enterobacteriaceae show increasing frequency of resistance to third-generation cephalosporin (3GC) antibiotics on the African continent but mortality impact has not been quantified.We used historic data from six hospitals assess 3GC clinical outcomes in Escherichia coli and Klebsiella pneumoniae BSI. We matched each bacteraemic patient two uninfected patients. compared between 3GC-susceptible 3GC-resistant BSI their respective controls using Cox...