A5059369373- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Cancer-related Molecular Pathways
- Global Maternal and Child Health
- Computational Drug Discovery Methods
- Estrogen and related hormone effects
- Bacteriophages and microbial interactions
- Microbial infections and disease research
- Cancer Mechanisms and Therapy
- Advanced Breast Cancer Therapies
- Genomics and Phylogenetic Studies
- Traditional and Medicinal Uses of Annonaceae
- Neonatal and Maternal Infections
- Berberine and alkaloids research
- Alkaloids: synthesis and pharmacology
- Receptor Mechanisms and Signaling
- Malaria Research and Control
National Hospital Abuja
2016-2025
University of Nigeria
2016-2023
Treatment of type 2 diabetes (T2D) remains a significant challenge because its multifactorial nature and complex metabolic pathways. There is growing interest in finding new therapeutic targets that could lead to safer more effective treatment options. Takeda G protein-coupled receptor 5 (TGR5) promising antidiabetic target plays key role regulation, especially glucose homeostasis energy expenditure. TGR5 agonists are attractive candidates for T2D therapy their ability improve glycemic...
Bacteria of the order Enterobacterales are common pathogens causing bloodstream infections in sub-Saharan Africa and frequently resistant to third-generation cephalosporin antibiotics. Although resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. We aimed measure effects associated with cephalosporins hospitalised patients infection Africa.
Introduction: Despite improved treatment options, colorectal cancer (CRC) remains a huge public health concern with significant impact on affected individuals. Cell cycle dysregulation and overexpression of certain regulators checkpoint activators are important recurring events in the progression cancer. Cyclin-dependent kinase 1 (CDK1), key regulator cell component central to uncontrolled proliferation malignant cells, has been reportedly implicated CRC. This study aimed identify CDK1...
Context Landolphia owariensis P. Beauv. (Apocyanaceae) leaf is used in southeast Nigeria to treat malaria.Objective This study evaluated the antiplasmodial activity of L. extract and fractions, also phytoconstituents were standardized analyzed.Methods The effects daily, oral administrations 200, 400 800 mg/kg (LOE), its hexane (LOHF), ethyl acetate (LOEF) methanol (LOMF) fractions on early, established residual infections Plasmodium berghei-infected albino mice vivo. subjected phytochemical...
Pseudomonas aeruginosa is a major pathogen in humans and other animals, frequently harboring mechanisms of resistance to commonly used antimicrobials. Here, we describe the isolation P. bacteriophage Zikora. The full 65,837-bp genome was annotated demonstrates similarity Pbunavirus phages, making Zikora new member this genus Myoviridae family.
Abstract Despite improved treatment options, colorectal cancer (CRC) remains a huge public health concern with significant impact on affected individuals. Cell cycle dysregulation and overexpression of certain regulators checkpoint activators are important recurring events in the progression cancer. Cyclin-dependent kinase 1 (CDK1), key regulator cell component central to uncontrolled proliferation malignant cells, has been reportedly implicated CRC. This study aimed identify CDK1 inhibitors...
Background: Malaria poses a global threat and challenge to healthcare despite the fact that it is treatable preventable. Though there are documented evidences on consequences of misdiagnosis malaria, presumptive diagnosis still being widely practiced by clinicians. Methods & Materials: A retrospective study involving case notes children who were treated for uncomplicated malaria at tertiary hospital was carried out. Data demographics, diagnostic procedures, drugs prescribed, presenting...
Background: Enterobacterales are common pathogens causing bloodstream infection (BSI) in sub-Saharan Africa and frequently resistant to 3rd generation cephalosporin (3GC) antibiotics. Although 3GC-resistance is believed lead adverse outcomes, this relationship difficult quantify has rarely been studied region. Methods: We conducted a prospective matched parallel cohort study of impacts BSI at eight hospitals across Africa. included all age-groups each patient ≥1 uninfected patients. analyzed...
Abstract Background: Bloodstream infections caused by Enterobacterales show high frequency of antimicrobial resistance (AMR) in many Low- and Middle-Income Countries. We aimed to describe the variation circumstances for management such resistant public-sector hospitals across sub-Saharan Africa. Methods: gathered data from eight Africa hospital services, infection prevention antibiotic stewardship activities, using two WHO-generated tools. collected monthly cross-sectional on availability...