A5067076025- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- COVID-19 diagnosis using AI
- Respiratory viral infections research
- Vaccine Coverage and Hesitancy
- Animal Disease Management and Epidemiology
- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV/AIDS Research and Interventions
- Viral Infections and Outbreaks Research
- HIV Research and Treatment
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS drug development and treatment
- Racial and Ethnic Identity Research
- T-cell and B-cell Immunology
- Biosensors and Analytical Detection
- Animal Virus Infections Studies
- COVID-19 and Mental Health
- Viral-associated cancers and disorders
- Travel-related health issues
- Receptor Mechanisms and Signaling
- COVID-19 Pandemic Impacts
- Livestock and Poultry Management
Noguchi Memorial Institute for Medical Research
2012-2025
University of Ghana
2012-2025
Yale University
2023
Center for Prevention Services
2021
Institute of Molecular and Cell Biology
2017-2018
National University Health System
2017-2018
Agency for Science, Technology and Research
2017-2018
National University of Singapore
2017-2018
Introduction Regular viral load (VL) testing for people living with HIV (PLWH) is key to attaining the Joint United Nations Program on HIV/AIDS (UNAIDS) Fast-Track 95–95-95 target end epidemic by 2030. However, VL remains sporadic in routine care majority of resource-limited settings, including Ghana, except when provided through research initiatives. In this study, we measured among PLWH Ghana at regular intervals and investigated factors affecting suppression (VS) rebound. Methods We...
The global annual attack rate for influenza is estimated to be 10%-20% in children, although limited information exists Africa. In 2007, Ghana initiated surveillance by routine monitoring of acute respiratory illness obtain data on circulating strains. We describe children <11 years old who had influenza-like (ILI) from January 2008 December 2010.Oropharyngeal swabs pediatric outpatients with ILI attending any 22 health facilities across the country were submitted. tested virus using...
Middle East respiratory syndrome coronavirus (MERS-CoV) causes diseases in humans and has a high mortality rate. During infection, MERS-CoV regulates several host cellular processes including antiviral response genes. In order to determine if the nucleocapsid protein of (MERS-N) plays role viral–host interactions, murine monoclonal antibody was generated so as allow detection infected cells well overexpression system. Then, MERS-N stably overexpressed A549 cells, PCR array containing 84...
Though antiretroviral therapy (ART) has reduced HIV infection into a manageable chronic disease, it does not provide for cure. cure trials may carry risks patients who are generally doing well on ART, making imperative that their input is sought as various types of methods and designed. Few studies have the views African studies. The objective this study was to determine preferences people living with (PLWH) in Ghana research.We used questionnaire interview 251 PLWH about willingness engage...
Hepatitis C virus (HCV) infection is a blood borne that remains potentially transmissible through transfusions. Sickle cell disease (SCD) common inheritable haemoglobinopathy in Ghana requires multiple transfusions as part of its management. The SCD patient therefore at high risk HCV infection; however, data on the occurrence patients has not been documented Ghana. This study sought to determine prevalence and genotypes patients.This was cross-sectional which enrolled 141 sickle-cell from...
Abstract Background Influenza A viruses that cause highly pathogenic avian influenza (HPAI) also infect humans. In many developing countries such as Ghana, poultry and humans live in close proximity both the general military populations, increasing risk for spread of HPAI from birds to Respiratory infections are especially prone rapid among populations living quarters barracks making this a key population targeted surveillance public health education. Method Twelve situated coastal, tropical...
A novel coronavirus, SARS-CoV-2 is currently causing a worldwide pandemic. The first cases of infection were recorded in Ghana on March 12, 2020. Since then, the country has been combatting countrywide community spread. This report describes how Virology Department, Noguchi Memorial Institute for Medical Research (NMIMR) supporting Health Service (GHS) to diagnose infections with this virus Ghana.The National Influenza Centre (NIC) Department NMIMR, adopted real-time Polymerase Chain...
Background Within HIV/HBV infected patients, an increase in HDV infection has been observed; there is inadequate information on prevalence as well virologic profile Ghana. This study sought to determine the presence of co-infected patients Methods was a longitudinal purposive which enrolled 113 attending clinic at Korle-Bu Teaching Hospital (KBTH) Accra, After consenting, 5 mL whole blood collected two-time points (baseline and 4–6 months afterwards). The sera obtained were tested confirm...
Military barracks in Ghana have backyard poultry populations but the methods used here involve low biosecurity measures and high risk zoonosis such as avian influenza A viruses or Newcastle disease. We assessed intended to minimize of virus infection among troops keepers military barracks. educated a questionnaire collect information on animal handling practices from 168 individuals within 203 households Cloacal tracheal samples were taken 892 healthy domestic domesticated wild birds, 91...
Background Influenza co-infection with bacteria is a leading cause of influenza-related deaths and severe respiratory infections, especially among high-risk groups like cancer patients undergoing treatment. However, acute infection (ARI)-like symptoms developed by upper-torso (UTC) receiving radiotherapy are considered as side-effects the radiation. Hence influenza bacterial pathogens implicated in ARI not investigated. Methods This prospective cohort study examined 85 in-patients cancers at...
Setting up a global SARS-CoV-2 surveillance system requires an understanding of how virus isolation and propagation practices, use animal or human sera, different neutralisation assay platforms influence assessment antigenicity. In this study, with the contribution 15 independent laboratories across all WHO regions, we carried out controlled analysis using first International Standard for antibodies to variants concern (source: NIBSC). Live isolates BioHub individual labs) spike plasmids...
Introduction. Antiretroviral therapy (ART) has reduced mortality and improved life expectancy among HIV patients but does not provide a cure. Patients must remain on lifelong medications deal with drug resistance side effects. This underscores the need for cure research. However, participation in research risks without guaranteed benefits. We determined what healthcare providers know about trials, involved, kind of interventions they are likely to recommend their patients. Methods. conducted...
Hepatocellular carcinoma (HCC) is a non-AIDS-defining cancer closely tied to the chronic HIV infection and associated with release of inflammatory cytokines, immune system dysfunction, genetic alterations within mitochondria. However, our understanding how these factors contribute HCC risk in PLWH limited. The objective study was ascertain differential secretion cytokines mitochondria DNA (mtDNA) deletion PLWH, individuals diagnosed without HIV. A cross-sectional conducted participants from...
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by asymptomatic individuals has been reported since the early stages disease 2019 (COVID-19) outbreak in various parts world. However, there are limited data regarding SARS-CoV-2 among Ghana. aim study was to use test prospective travelers from Ghana as a proxy estimate contribution cases COVID-19.The analyzed PCR clients whose purpose for testing classified "Travel" at COVID-19 walk-in center Noguchi Memorial...
To determine the prevalence of SARS-CoV-2 detection among international travellers to Ghana during mandatory quarantine.A retrospective cross-sectional study.Air on 21st and 22nd March 2020.On 2020, a total 1,030 returning were mandatorily quarantined in 15 different hotels Accra tested for SARS-CoV-2. All these persons included study.Positivity by polymerase chain reaction.The initial testing at beginning quarantine found 79 (7.7%) individuals be positive In exit screening after 12 13 days...
In March 2020, the first cases of SARS-CoV-2 were reported in Accra, Ghana. These initial diagnosed at Advanced Research Laboratories (ARL) Noguchi Memorial Institute for Medical (NMIMR), University The ARL which hitherto was used routine clinical research viral, bacteria and immunological studies has since been facility choice testing all suspected COVID-19 submitted from across Ghana beyond. success hinged on availability several laboratory spaces furnished with state-of-the-art diagnostic...
The COVID-19 pandemic caused by SARS-CoV-2 is an important subject for global health. Ghana experienced low-moderate transmission of the disease when first case was detected in March 12, 2020 until middle July number cases begun to drop. By August 24, 2020, country's total confirmed stood at 43,622, with 263 deaths. same time, Noguchi Memorial Institute Medical Research (NMIMR) University Ghana, primary testing centre COVID-19, had tested 285,501 28,878 cases. Due database gaps, there were...
Objective: This study aimed to determine the duration of SARS-CoV-2 clearance in persons Ghana. The research question was whether virus Ghana matched 14 days recommended by World Health Organization (WHO); this had direct implications for transmission, which key managing COVID-19 pandemic.Design: a retrospective analytical study.Setting: All facilities that submitted clinical specimens Noguchi Memorial Institute Medical Research (NMIMR) diagnosis between March June 2020 were included...
<h3>Background</h3> Fc gamma receptors (FcγR) are cell surface glycoproteins that bind to the portions of immunoglobulin IgG antibodies elicit diverse effector functions. Polymorphisms in different FcγR genes have been associated with HIV infection and vaccine trial outcomes. Some studies suggested FcγRIIa may be a marker latent reservoir size, however, this remains controversial. Hence whether other functional consequences on size or reactivation capacity needs investigated....
The World Health Organization's case definition for influenza-like illness (ILI) includes a measured temperature of ≥38°C. We conducted this study to assess the effect antipyretics on performance ILI surveillance in Ghana.A cross-sectional was two districts Ghana from September 2013 May 2014. collected epidemiological data and respiratory specimens an expanded definition, which included patients presenting health facilities with ≥38°C or reported fever (but afebrile at time evaluation),...