A5002319681- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Mosquito-borne diseases and control
- COVID-19 epidemiological studies
- HIV Research and Treatment
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- SARS-CoV-2 detection and testing
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Immune responses and vaccinations
- Complement system in diseases
- Viral Infections and Outbreaks Research
- COVID-19 diagnosis using AI
- Monoclonal and Polyclonal Antibodies Research
- Parasites and Host Interactions
- Biomarkers in Disease Mechanisms
- COVID-19 Clinical Research Studies
- Glycosylation and Glycoproteins Research
- Hepatitis Viruses Studies and Epidemiology
- Vaccine Coverage and Hesitancy
- Academic Publishing and Open Access
- Blood Coagulation and Thrombosis Mechanisms
- Blood donation and transfusion practices
- Apelin-related biomedical research
Noguchi Memorial Institute for Medical Research
2011-2025
University of Ghana
2008-2025
Washington University in St. Louis
2022
Aziende Socio Sanitaria Territoriale Rhodense
2021
Institut Pasteur de Dakar
2021
Antigen-specific antibody-mediated immune responses play an important role in natural protection against clinical malaria, but conflicting estimates of this association have emerged from immuno-epidemiological studies different geographical settings. This study was aimed at assessing a standardized manner the relationship between antibody to four malaria vaccine candidate antigens and cohort Ghanaian children. Standardized ELISA protocols were used measure isotype IgG subclass levels Apical...
The gametocyte stage of Plasmodium falciparum is considered an important target for disrupting malaria transmission. Indications are that various demographic groups, such as children and pregnant women may differ in risk harbouring gametocytes, which be crucial targeted control. In this study, the relationship between prevalence multiplicity P. falciparum, asexual parasite infections gametocytaemia was assessed three different groups area southern Ghana with low endemicity. Levels antibody...
Introduction Regular viral load (VL) testing for people living with HIV (PLWH) is key to attaining the Joint United Nations Program on HIV/AIDS (UNAIDS) Fast-Track 95–95-95 target end epidemic by 2030. However, VL remains sporadic in routine care majority of resource-limited settings, including Ghana, except when provided through research initiatives. In this study, we measured among PLWH Ghana at regular intervals and investigated factors affecting suppression (VS) rebound. Methods We...
Considering the natural history of malaria continued susceptibility to infection and episodes illness that decline in frequency severity over time, studies which attempt relate immune response protection must be longitudinal have clearly specified definitions status. Putative vaccines are expected protect against infection, mild or severe disease reduce transmission, but so far it has not been easy establish what constitutes protective immunity how this develops naturally, especially among...
Background The protective effect of certain haemoglobinopathies, such as HbS, HbC, and α-thalassaemia, against severe malaria has long been established; however, there is only limited equivocal evidence regarding their impact on asymptomatic parasitaemia. Here, we investigated the α-thalassaemia P. falciparum parasitaemia acquired immunity among children in Northern Ghana. Materials methods A cross-sectional study was conducted 1,017 healthy (1-17 years) 13 malaria-endemic communities were...
The surge in malaria cases and deaths recent years, particularly Africa, despite the widespread implementation of malaria-control measures could be due to inefficiencies control prevention malaria-endemic communities. In this context, study provides situation report among children three Municipalities Northern Ghana, where Seasonal Malaria Chemotherapy (SMC) is implemented by Ghana Health Service (GHS). A cross-sectional household survey was carried out assess knowledge, attitudes, practices...
Abstract Background Alterations in the structure of haemoglobin (Hb) are usually brought about by point mutations affecting one or, some cases, two codons encoding amino acids globin chains. One three Ghanaians said to have sickle cell disorders, whereas malaria continues be leading causes mortality among children. This study determined prevalence disorders and infection children aged 1–12 years Volta Region. Methods was a community-based cross-sectional survey that involved 938 selected...
Plasmodium falciparum parasites causing placental malaria express the VAR2CSA type of clonally variant antigen family erythrocyte membrane protein 1 (PfEMP1). This enables evasion preexisting immunity and results in accumulation infected erythrocytes. We present data on seasonal variation levels VAR2CSA-specific immunoglobulin G (IgG) IgG specific for a malaria–unrelated PfEMP1 among Ghanaian women at their first antenatal visit. Our indicate that does not require recent exposure to...
Though antiretroviral therapy (ART) has reduced HIV infection into a manageable chronic disease, it does not provide for cure. cure trials may carry risks patients who are generally doing well on ART, making imperative that their input is sought as various types of methods and designed. Few studies have the views African studies. The objective this study was to determine preferences people living with (PLWH) in Ghana research.We used questionnaire interview 251 PLWH about willingness engage...
A novel coronavirus, SARS-CoV-2 is currently causing a worldwide pandemic. The first cases of infection were recorded in Ghana on March 12, 2020. Since then, the country has been combatting countrywide community spread. This report describes how Virology Department, Noguchi Memorial Institute for Medical Research (NMIMR) supporting Health Service (GHS) to diagnose infections with this virus Ghana.The National Influenza Centre (NIC) Department NMIMR, adopted real-time Polymerase Chain...
<ns3:p>Following the coronavirus outbreaks described as severe acute respiratory syndrome (SARS) in 2003 and Middle East (MERS) 2012, world has again been challenged by yet another corona virus, named 2 (SARS-CoV-2). SARS-CoV-2 infections were first detected a Chinese Province December 2019 then declared pandemic World Health Organization March 2020. An infection caused may result asymptomatic, uncomplicated or fatal disease (COVID-19). Fatal linked with uncontrolled “cytokine storm”...
Abstract Members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family are important targets for protective immunity. Abnormal display PfEMP1 on surfaces infected erythrocytes (IEs) and reduced cytoadhesion have been demonstrated in hemoglobin (Hb) AS HbAC, inherited blood disorders associated with protection against severe P. malaria. We found that Ghanaian children HbAS had lower levels immunoglobulin G several variants this reactivity increased more slowly age than...
The alpha-thalassaemia trait has been associated with protection against severe malaria but its role in Plasmodium falciparum asexual parasite and gametocyte carriage remains unclear. This study examined association between prevalence of α-thalassaemia P. stage parasitaemia gametocytaemia children, pregnant women adults, which was part a bigger that investigated some key factors influence carriage.Overall heterozygous among all the groups 39.0%, while 8.2% were homozygous alpha thalassaemia....
<ns3:p>Following the coronavirus outbreaks described as severe acute respiratory syndrome (SARS) in 2003 and Middle East (MERS) 2012, world has again been challenged by yet another corona virus, named 2 (SARS-CoV-2). SARS-CoV-2 infections were first detected a Chinese Province December 2019 then declared pandemic World Health Organization March 2020. An infection caused may result asymptomatic, uncomplicated or fatal disease (COVID-19). Fatal linked with uncontrolled “cytokine storm”...
Heterozygous carriers of haemoglobin S and C (HbAS HbAC) have a reduced risk severe malaria but are not protected from Plasmodium falciparum infection, suggesting that the protection involves acquired immunity. During blood meal, female Anopheles mosquitoes inject saliva can elicit host antibody response, which serve as proxy for exposure to infection. Previous studies shown peptide gSG6-P1 An. gambiae is antigenic highly specific. Here, we used plasma samples 201 Ghanaian children with...
<ns3:p>Following the coronavirus outbreaks described as severe acute respiratory syndrome (SARS) in 2003 and Middle East (MERS) 2012, world has again been challenged by yet another corona virus, named 2 (SARS-CoV-2). SARS-CoV-2 infections were first detected a Chinese Province December 2019 then declared pandemic World Health Organization March 2020. An infection caused may result asymptomatic, uncomplicated or fatal disease (COVID-19). Fatal linked with uncontrolled “cytokine storm”...
The COVID-19 pandemic is spreading through Africa and governments are making frantic efforts to control spread, hospitalizations deaths. While measures being taken, research into the biomedical socio-cultural aspects of pandemic, relevant African population, should not be ignored. It assumed that performed in Asian, American European populations will always applicable Africa. Rather, done answer questions peculiar epidemic on continent help inform international guidelines. National...
Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed plasma concentrations Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR sICAM-1 in a cohort Beninese children with malaria investigate their potential association manifestations malaria. We found that all molecules showed higher levels severe or cerebral...
Haemoglobin genotype S is known to offer protection against Plasmodium falciparum infections but the mechanism underlying this not completely understood. Associated changes in acute phase proteins (APPs) during between AA (HbAA) and AS (HbAS) individuals also remain unclear. This study aimed evaluate three APPs full blood count (FBC) indices of HbAA HbAS children infection.Venous was collected from hundred twenty (6 months 15 years) Begoro Fanteakwa District Ghana a cross-sectional study....
Introduction. Antiretroviral therapy (ART) has reduced mortality and improved life expectancy among HIV patients but does not provide a cure. Patients must remain on lifelong medications deal with drug resistance side effects. This underscores the need for cure research. However, participation in research risks without guaranteed benefits. We determined what healthcare providers know about trials, involved, kind of interventions they are likely to recommend their patients. Methods. conducted...
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by asymptomatic individuals has been reported since the early stages disease 2019 (COVID-19) outbreak in various parts world. However, there are limited data regarding SARS-CoV-2 among Ghana. aim study was to use test prospective travelers from Ghana as a proxy estimate contribution cases COVID-19.The analyzed PCR clients whose purpose for testing classified "Travel" at COVID-19 walk-in center Noguchi Memorial...