A5001653814- RNA and protein synthesis mechanisms
- RNA modifications and cancer
- Biomarkers in Disease Mechanisms
- CO2 Reduction Techniques and Catalysts
- Apelin-related biomedical research
- Mosquito-borne diseases and control
- Metalloenzymes and iron-sulfur proteins
- Microbial Fuel Cells and Bioremediation
- Hemoglobinopathies and Related Disorders
- Malaria Research and Control
- Bacterial Genetics and Biotechnology
- Blood Coagulation and Thrombosis Mechanisms
- DNA and Nucleic Acid Chemistry
Mère et Enfant en Milieu Tropical
2021-2023
Université Paris Cité
2020-2023
Institut de Recherche pour le Développement
2021-2023
Centre de Recherche des Cordeliers
2020-2022
Inserm
2020
Sorbonne Université
2020
Xenobiotic nucleic acids (XNAs) offer tremendous potential for synthetic biology, biotechnology, and molecular medicine but their ability to mimic still needs be explored. Here, study the of XNA oligonucleotides tRNA, we synthesized three L-Ala-tXNAs analogs. These molecules were used in a non-ribosomal peptide synthesis involving bacterial Fem transferase. We compared this enzyme use amino-acyl tXNAs containing 1',5'-anhydrohexitol (HNA), 2'-fluoro ribose (2'F-RNA) arabinose. L-Ala-tXNA HNA...
The sequence of tRNAs is submitted to evolutionary constraints imposed by their multiple interactions with aminoacyl-tRNA synthetases, translation elongation factor Tu in complex GTP (EF-Tu•GTP), and the ribosome, each being essential for accurate effective decoding messenger RNAs. In Staphylococcus aureus, an additional constraint participation tRNAGly isoacceptors addition a pentaglycine side chain cell-wall peptidoglycan precursors transferases FmhB, FemA FemB. Three poorly interacting...
Malaria-related deaths could be prevented if powerful diagnostic and reliable prognostic biomarkers were available to allow rapid prediction of the clinical severity allowing adequate treatment. Using quantitative ELISA, we assessed plasma concentrations Procalcitonin, Pentraxine-3, Ang-2, sTie-2, suPAR, sEPCR sICAM-1 in a cohort Beninese children with malaria investigate their potential association manifestations malaria. We found that all molecules showed higher levels severe or cerebral...
Among the barriers to accessing adequate treatment and high-level monitoring for malaria febrile patients is lack of effective prognostic markers. Neopterin, which a marker monocyte/macrophage activation, was found have increased during severe malaria. In this study, we used quantitative ELISA in order assess levels plasma soluble neopterin 151 from cohort Beninese children with We evaluated accuracy molecule predict outcome disease. Our results show that were not significantly different...
Abstract Background: Malaria-related deaths could be prevented if prompt diagnosis and prognostic biomarkers are available to allow rapid adequate treatment. Understanding of the mechanisms implicated in progression from P. falciparum asymptomatic uncomplicated malaria infections severe life-threatening disease is necessary identify such indicators. Methods : Using quantitative ELISA, we assessed plasma concentrations Procalcitonin, Pentraxine 3, Ang-2, sTie-2, suPAR, sEPCR, sICAM-1 a cohort...