A5012676653- Olfactory and Sensory Function Studies
- Neurogenesis and neuroplasticity mechanisms
- Fish biology, ecology, and behavior
- Ichthyology and Marine Biology
- Animal Vocal Communication and Behavior
- Neuroendocrine regulation and behavior
- Neurobiology and Insect Physiology Research
- Marine animal studies overview
- Bat Biology and Ecology Studies
- Circadian rhythm and melatonin
- Glaucoma and retinal disorders
- Fish Ecology and Management Studies
- Biochemical Analysis and Sensing Techniques
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Fish Biology and Ecology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- Developmental Biology and Gene Regulation
- Sleep and Wakefulness Research
- Epilepsy research and treatment
- Vestibular and auditory disorders
- Immune Response and Inflammation
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
Humboldt-Universität zu Berlin
2020-2025
Columbia University
2023-2024
Children's National
2014-2020
Saarland University
2012-2018
Center for Neurosciences
2014
University of Turin
2011-2014
Neuroscience Institute
2014
Accademia Albertina delle Belle Arti
2009
The mouse vomeronasal organ (VNO) has a pivotal role in chemical communication. sensory neuroepithelium consists of distinct populations neurons (VSNs). A subset VSNs, with cell bodies the basal part layer, coexpress Vmn2r G-protein-coupled receptor genes H2-Mv genes, family nine nonclassical class I major histocompatibility complex genes. vivo , physiological roles gene remain mysterious more than decade after discovery combinatorial expression VSNs. Here, we have taken genetic approach and...
Optimal reproductive fitness is essential for the biological success and survival of species. The vomeronasal organ strongly implicated in display sexual behaviors female mice, yet roles that apical basal neuron populations play controlling these gender-specific remain largely unclear. To dissect neural pathways underlying functions, we genetically inactivated layer using conditional, cell-specific ablation G protein Gαo. Female mice mutant Gαo show severe alterations behaviors, timing...
In the olfactory bulb of adult rodents, local interneurons are constantly replaced by immature precursors derived from subventricular zone. Whether any sensory process specifically relies on this cell renewal remains largely unclear. By using well-known model mating-induced imprinting, we demonstrate that memory formation critically depends presence newborn granule neurons in accessory bulb. Accordingly, show that, female mice, exposure to male pheromones increases number new cells surviving...
Since the pioneering work by Moeller, Szabo, and Bullock, weakly electric fish have served as a valuable model for investigating spatial social cognitive abilities in vertebrate taxon usually less accessible than mammals or other terrestrial vertebrates. These fish, through their organ, generate low-intensity fields to navigate interact with conspecifics, even complete darkness. The brown ghost knifefish is appealing study subject due rich ‘vocabulary’, made individually variable...
Abstract Newborn neurons generated by proliferative progenitors in the adult subventricular zone (SVZ) integrate into olfactory bulb circuitry of mammals. Survival these newly‐formed cells is regulated input. The presence new accessory (AOB) has already been demonstrated some mammalian species, albeit their neurochemical profile and functional integration AOB circuits are still to be investigated. To unravel whether mouse represents a site constitutive neurogenesis this process can modulated...
The hormonal state during the estrus cycle or pregnancy produces alterations on female olfactory perception that are accompanied by specific maternal behaviors, but it is unclear how sex hormones act system to enable these sensory changes. Herein, we show production of neuronal progenitors stimulated in vomeronasal organ (VNO) epithelium mice a late phase pregnancy. Using wide range molecular markers cover whole VNO cell maturation process combination with Ca2+ imaging early postmitotic...
The medial subnucleus of the amygdala (MeA) plays a central role in processing sensory cues required for innate behaviors. However, whether there is link between developmental programs and emergence inborn behaviors remains unknown. Our previous studies revealed that telencephalic preoptic area (POA) embryonic niche novel source MeA destined progenitors. Here, we show POA comprised distinct progenitor pools complementarily marked by transcription factors Dbx1 Foxp2. As determined molecular...
In the adult brain, active stem cells are a subset of astrocytes residing in subventricular zone (SVZ) and dentate gyrus (DG) hippocampus. Whether quiescent neuronal progenitors occur other brain regions is unclear. Here, we describe novel neurogenic system external capsule lateral striatum (EC-LS) juvenile guinea pig that at birth but becomes around weaning. Activation neurogenesis this region was accompanied by emergence neurogenic-like niche ventral EC characterized chains neuroblasts,...
Abstract Interconnections between the olfactory bulb and amygdala are a major pathway for triggering strong behavioral responses to variety of odorants. However, while this broad mapping has been established, patterns feedback connectivity influence on circuitry remain unknown. Here, using combination neuronal tracing approaches, we dissect cortical [posteromedial nucleus (PmCo)] circuit innervating mouse accessory bulb. Optogenetic activation PmCo mainly results in feedforward mitral cell...
The vomeronasal system (VNS) is specialized in the detection of salient chemical cues triggering social and neuroendocrine responses. Such responses are not always stereotyped, instead, they vary depending on age, sex reproductive state, yet mechanisms underlying this variability unclear. Here, by analyzing neuronal survival first processing nucleus VNS, namely accessory olfactory bulb (AOB), through multiple bromodeoxyuridine (BrdU) birthdating protocols, we show that exposure female mice...
Neurons in the hypothalamus function to regulate state of animal during both learned and innate behaviors, alterations hypothalamic development may contribute pathological conditions such as anxiety, depression or obesity. Despite many studies function, link between embryonic behaviors remains unexplored. Here, focusing on embryonically expressed homeodomain-containing gene Developing Brain Homeobox 1 (Dbx1), we explored relationship lineage, post-natal neuronal identity lineage-specific...
Neurogranin (Ng) is a brain-specific postsynaptic calmodulin-binding protein involved in synaptic activity-dependent plasticity. In the adult olfactory bulb (OB), Ng expressed by large population of GABAergic interneurons granule cell layer. We show here that, during postnatal development, also OB neurons superficial external plexiform layer (sEPL) and glomerular (GL). These Ng-positive display morphological neurochemical features tufted cells. expression these cells transient development:...
Voltage-gated calcium (Cav) channels are a prerequisite for signal transmission at the first olfactory sensory neuron (OSN) synapse within glomeruli of main bulb (MOB). We showed previously that N-type Cav channel subunit Cav2.2 is present in vast majority and plays central role presynaptic transmitter release. Here, we identify distinct subset MOB adult mice characterized by expression P/Q-type Cav2.1. Immunolocalization shows Cav2.1+ reside predominantly medial dorsal MOB, vicinity...
Since the pioneering work by Moeller, Szabo, and Bullock, weakly electric fish have served as a valuable model for investigating spatial social cognitive abilities in vertebrate taxon usually less accessible than mammals or other terrestrial vertebrates. These fish, through their organ, generate low-intensity fields to navigate interact with conspecifics, even complete darkness. The brown ghost knifefish is one of most widely studied species due its rich vocabulary, made individually...
Since the pioneering work by Moeller, Szabo, and Bullock, weakly electric fish have served as a valuable model for investigating spatial social cognitive abilities in vertebrate taxon usually less accessible than mammals or other terrestrial vertebrates. These fish, through their organ, generate low-intensity fields to navigate interact with conspecifics, even complete darkness. The brown ghost knifefish is one of most widely studied species due its rich vocabulary, made individually...