A5065073643- Pharmacogenetics and Drug Metabolism
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Electroconvulsive Therapy Studies
- Vitamin D Research Studies
- Potassium and Related Disorders
- Adrenal Hormones and Disorders
- Pharmacovigilance and Adverse Drug Reactions
- Schizophrenia research and treatment
- Gastroesophageal reflux and treatments
- Ion Transport and Channel Regulation
- Statistical Methods in Clinical Trials
- Atrial Fibrillation Management and Outcomes
- Pituitary Gland Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- Estrogen and related hormone effects
- Treatment of Major Depression
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical Practices and Patient Outcomes
- Eicosanoids and Hypertension Pharmacology
- Inflammatory mediators and NSAID effects
- Vitamin K Research Studies
- Cancer Treatment and Pharmacology
- Diet and metabolism studies
Karolinska University Hospital
2016-2025
Karolinska Institutet
2016-2025
Linköping University
2019
Ryhov Hospital Jönköping
2012
Stockholm University College of Music Education
2003
We report the first genome-wide association study (GWAS) whose sample size (1,053 Swedish subjects) is sufficiently powered to detect significance (p<1.5 x 10(-7)) for polymorphisms that modestly alter therapeutic warfarin dose. The anticoagulant drug widely prescribed reducing risk of stroke, thrombosis, pulmonary embolism, and coronary malfunction. However, Caucasians vary (20-fold) in dose needed anticoagulation, hence doses may be too low (risking serious illness) or high severe...
Well-characterized genes that affect warfarin metabolism (cytochrome P450 (CYP) 2C9) and sensitivity (vitamin K epoxide reductase complex 1 (VKORC1)) explain one-third of the variability in therapeutic dose before international normalized ratio (INR) is measured. To determine genotypic relevance after INR becomes available, we derived clinical pharmacogenetic refinement algorithms on basis values (on day 4 or 5 therapy), factors, genotype. After adjusting for INR, CYP2C9 VKORC1 genotypes...
Low serum levels of 25-hydroxyvitamin D(3) are associated with an increased risk respiratory tract infections (RTIs). Clinical trials vitamin against various have been carried out but data so far not conclusive. Thus, there is a need for additional randomised controlled effects on infections.To investigate if supplementation could reduce infectious symptoms and antibiotic consumption among patients antibody deficiency or frequent RTIs.A double-blind trial.Karolinska University Hospital,...
The objective of the study was to update a previous NONMEM model describe relationship between warfarin dose and international normalized ratio (INR) response, decrease dependence on pharmacokinetic (PK) data, improve characterization rare genotype combinations. effects age CYP2C9 S-warfarin clearance were estimated from high-quality PK data. Thereafter, temporal dose-response (K-PD) developed information dose, INR, age, VKORC1 genotype, with drug as covariate. Two transit compartment chains...
Summary By guiding initial warfarin dose, pharmacogenetic (PGx) algorithms may improve the safety of initiation. However, once international normalised ratio (INR) response is known, contribution PGx to dose refinements uncertain. This study sought develop and validate clinical dosing for refinement on days 6–11 after therapy An sample 2,022 patients at 13 medical centres three continents provided clinical, INR, genetic data treatment predict therapeutic dose. Independent derivation...
It is unclear if nonfunctional adrenal adenomas (NFAAs) are associated with increased mortality.To analyze mortality and causes of death in patients NFAA.A national retrospective register-based case-control study was conducted included 17 726 a diagnosis adenoma Sweden from 2005 to 2019 who were identified followed up until or 2020 as well 124 366 controls without adenoma. Individuals diagnoses indicating hormonal excess cancer excluded. Follow-up started after 3 months cancer-free survival...
Importance It is unclear whether nonfunctional adrenal tumors (NFATs) are associated with fractures. Objective To analyze fracture frequencies in individuals NFATs. Design, Setting, and Participants A national retrospective cohort study was conducted patients NFATs diagnosed Sweden between January 1, 2005, December 31, 2019, control participants without followed up until death or the end of 2019. Individuals a diagnosis hormonal excess previous malignant were excluded. Sensitivity analyses...
Hyponatremia is the most common electrolyte disorder, with potentially serious consequences. Studies validating hyponatremia used as a principal diagnosis are lacking. Studying diagnoses important since it indicates main reason for inpatient care. The aim of this study was to assess validity according International Classification Diseases, tenth revision (ICD-10) in patients discharged from hospital. Three independent reviewers retrospectively analyzed medical records 428 hospitalized...
Objective Our objective was to prospectively study the impact of CYP2C9 polymorphism (*2 and *3) on risk overanticoagulation during induction phase warfarin therapy. Methods Blood samples for genotyping were collected from 219 patients requiring therapy, clinical data first 3 weeks medication. Patients divided into groups according genotype, as follows: *1 (homozygous), *2 (*1/*2 *2/*2), *3 (any genotype containing allele). Results During week treatment, relative achieving at least 1...
The most important enzyme in hepatic drug metabolism is cytochrome P450 3A4. Published vitro data indicate that vitamin D may up-regulate the expression of <i>CYP3A4</i> gene. Individual levels are highly dependent on sunlight exposure and show great seasonal variability northern countries. aim present study was to investigate whether plasma concentrations CYP3A4 substrates exhibit changes compatible with a stimulatory effect metabolism. Three immunosuppressants (tacrolimus, sirolimus,...
Hyponatremia induced by antiepileptic drugs is common, but detailed evidence lacking. This can be problematic for the treating neurologist confronted with a patient severe hyponatremia in need of an alternative drug. The objective this study was to examine association between individual and hospitalization due hyponatremia.This register-based case-control patients general Swedish population. We included 14,359 individuals principal diagnosis 57,383 matched controls. newly initiated (≤90...