A5102018876- Immune Cell Function and Interaction
- Cerebrospinal fluid and hydrocephalus
- Renal and related cancers
- Hedgehog Signaling Pathway Studies
- Genetic and Kidney Cyst Diseases
- Pluripotent Stem Cells Research
- Developmental Biology and Gene Regulation
- T-cell and B-cell Immunology
- Ion Channels and Receptors
- Bioactive Compounds and Antitumor Agents
- Signaling Pathways in Disease
Heidelberg University
2016-2019
Calcium signals in stimulated T cells are generally considered single entities that merely trigger immune responses, whereas costimulatory events specify the type of reaction. Here we show "T cell calcium signal" is a composite signal harboring two distinct components antagonistically control genomic programs underlying response. Using human from healthy individuals, establish nuclear as key adaptogenomics drives activation and required for signaling to cyclic adenosine monophosphate...
In the adult mammalian brain apical surface of subependymal zone (SEZ) is covered by many motile ependymal cilia and a few primary originating from rare intermingled neural stem cells (NSCs). NSCs are key for transduction essential extracellular signals such as Sonic hedgehog (SHH) platelet-derived growth factor (PDGF). Despite their importance, analysis NSC greatly hampered fact that they overwhelmingly outnumbered cilia. We here take advantage flow cytometry to purify two types allow...
Highlights•TLX autonomously controls quiescence in apical NSCs by repressing Hes1•TLX basal progenitor proliferation via NOTCH-mediated lateral inhibition•Downregulation of Hes1 Tlx−/− resumes and neurogenesisSummaryIn the adult subependymal zone (SEZ), neural stem cells (NSCs) apically contacting ventricle on activation generate progenitors proliferating at niche side. We here show that Tailless (TLX) coordinates NSC NOTCH effector Hes1. Consistent with this, besides expression also...