A5015726750- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Advanced MRI Techniques and Applications
- Aortic aneurysm repair treatments
- Lattice Boltzmann Simulation Studies
- Congenital Heart Disease Studies
- Solar Thermal and Photovoltaic Systems
- Coronary Interventions and Diagnostics
- Mathematics, Computing, and Information Processing
- Markov Chains and Monte Carlo Methods
- Cardiomyopathy and Myosin Studies
- Healthcare Technology and Patient Monitoring
- Phonocardiography and Auscultation Techniques
- Simulation Techniques and Applications
- Orthopaedic implants and arthroplasty
- Elasticity and Material Modeling
- Fluid Dynamics and Vibration Analysis
- Polynomial and algebraic computation
- Renal Transplantation Outcomes and Treatments
- Cardiac pacing and defibrillation studies
- Cardiovascular Health and Disease Prevention
- Radiative Heat Transfer Studies
Stanford University
2020-2024
Cardiovascular Institute of the South
2024
Courant Institute of Mathematical Sciences
2013-2019
New York University
2013-2019
Hospital of the University of Pennsylvania
2015
University of Colorado Boulder
2012
Abstract This work is concerned with modeling and simulation of the mitral valve, one four valves in human heart. The valve composed leaflets, free edges which are supported by a system chordae, themselves anchored to papillary muscles inside left ventricle. First, we examine anatomy present results original dissections. These display gross information on fiber structure valve. Next, build model following design‐based methodology, meaning that derive geometry forces needed support given load...
ObjectiveTo investigate the effect of graft sizing on valve performance in valve-sparing aortic root replacement for bicuspid valve.MethodsIn addition to a diseased control model, 3 representative groups—free-edge length aortic/graft diameter (FELAD) ratio <1.3, 1.5 1.64, and >1.7—were replicated explanted porcine roots (n = 3) using straight grafts sized respective native free-edge length. They were run validated ex vivo univentricular system under physiological parameters 20 cycles. All...
Progressive aortic valve disease has remained a persistent cause of concern in patients with left ventricular assist devices. Aortic incompetence (AI) is known predictor both mortality and readmissions this patient population remains challenging clinical problem.
Annuloplasty ring choice and design are critical to the long-term efficacy of mitral valve (MV) repair. DynaRing is a selectively compliant annuloplasty composed varying stiffness elastomer segments, shape-set nitinol core, cross diameter filament. The provides sufficient stabilize diseased annulus while allowing physiological annular dynamics. Moreover, adjusting properties mechanism for effectively tuning key MV metrics specific patients. We evaluate embedded in porcine valves with an...
In an effort to improve the reliability of detection congestive heart failure, a method utilizing phase shifts cardiac and thoracic acoustics coupled with ECG signals is described. The system consists bipolar electrodes placed on pectoral muscles acoustic transducers that monitor four locations across chest back. tested six healthy individuals; there are five males one female. Amplitude electric vary significantly so spectral analysis utilized for classification. Frequency data shows...
The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics anatomy with humans ease experimental manipulations. Computational fluid-structure interaction (FSI) simulations are an efficient highly controllable means study the function valves in diseases. Due their small scales, little known about mechanical properties valves, limiting existing computational studies blood. To circumvent these limitations, we took largely...
Introduction: Aortic dilation and aneurysm formation is common in patients with a bicuspid aortic valve. Hemodynamics genetics are both believed to cause dilation, but the relative contributions remain controversial. Further, retrospective studies assess hemodynamics when has already set in. We simulate flows through tricuspid three valves study their from baseline non-dilated aorta. Hypothesis: hypothesize that phenotype determines flow ascending aortic, high velocity jets will correlate...
This thesis is concerned with modeling and simulation of the mitral valve, one four valves in human heart. The valve composed leaflets attached to a ring, free edges which are supported by system chordae, themselves anchored muscles inside First, we examine anatomy show results original dissections. These display gross information on fiber structure valve. Next, build model following design-based approach elasticity. We incorporate from dissections specify topology this model. assume...
The immersed boundary (IB) method is a mathematical framework for fluid-structure interaction problems (FSI) that was originally developed to simulate flows around heart valves. Direct comparison of FSI simulations valves against experimental data challenging, however, due the difficulty performing robust and effective simulations, complications modeling specific physical experiment, need acquire directly comparable simulation data. Such comparators are necessary precursor further formal...