A5059875854- Genetics, Aging, and Longevity in Model Organisms
- Mitochondrial Function and Pathology
- Microtubule and mitosis dynamics
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Neurobiology and Insect Physiology Research
- Cellular Mechanics and Interactions
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Plant Molecular Biology Research
UMass Memorial Medical Center
2025
University of Massachusetts Chan Medical School
2022-2025
National Brain Research Centre
2019-2021
Organisms have evolved protective strategies that are geared toward limiting cellular damage and enhancing organismal survival in the face of environmental stresses, but how these mechanisms coordinated remains unclear. Here, we define a requirement for neural activity mobilizing antioxidant defenses nematode Caenorhabditis elegans both during prolonged oxidative stress prior to its onset. We show acetylcholine-deficient mutants particularly vulnerable stress. find mobilizes broad...
Neuronal polarization is facilitated by the formation of axons with parallel arrays plus-end-out and dendrites nonuniform orientation microtubules. In C. elegans, posterior lateral microtubule (PLM) neuron bipolar its two processes growing along anterior–posterior axis under guidance Wnt signaling. Here we found that loss Kinesin-13 family microtubule-depolymerizing enzyme KLP-7 led to ectopic extension axon-like from PLM cell body. Live imaging microtubules axonal transport revealed mixed...
The elimination of synapses during circuit remodeling is critical for brain maturation; however, the molecular mechanisms directing synapse and its timing remain elusive. We show that transcriptional regulator DVE-1, which shares homology with special AT-rich sequence-binding (SATB) family members previously implicated in human neurodevelopmental disorders, directs juvenile synaptic inputs onto C. elegans GABAergic neurons. Juvenile acetylcholine receptor clusters apposing presynaptic sites...
Neuronal polarization is defined by the formation of axons with parallel arrays plus-end-out and dendrites non-uniform orientation microtubules (MTs). In C. elegans, Posterior Lateral Microtubule (PLM) neuron bipolar its two processes growing along anterior-posterior axis under guidance WNT signaling. Live imaging axonal transport EBP-2::GFP GFP::RAB-3 reporters, respectively revealed mixed polarity MTs negligible RAB-3 in short posterior process suggesting dendrite like nature. Genetic...
Abstract An important step in brain development is the remodeling of juvenile neural circuits to establish mature connectivity. The elimination synapses a critical this process; however, molecular mechanisms directing synapse activities and their timing are not fully understood. We identify here conserved transcriptional regulator, DVE-1, that shares homology with mammalian special AT-rich sequence-binding (SATB) family members directs synaptic inputs onto C. elegans GABAergic neurons....