Abstract Neuroblastoma is the most common extracranial solid tumor found in children and survival rate extremely meager. HDAC8, a class I zinc-dependent enzyme, potential drug target for treatment of neuroblastoma T cell lymphoma. Most HDAC8 inhibitors discovered till date contains hydroxamic acid group which acts as zinc binding group. The high affinity to other ions results adverse effects. Also, non-selective inhibition HDACs cause variety side objective this identify structurally...

Treatment of Cp2ZrBu2 with enol ether containing a remote double bond lead to conjugated metalated diene as single isomer via tandem isomerization-elimination sequence. 2-Arylsulfonyl 1,3-dienes can also be used source dienyl zirconocene derivatives, and the stereochemistry is dependent on transmetalation reaction.

Bipolar resistive switching using organic molecule is very promising for memory applications owing to their advantages, such as simple device structure, low manufacturing cost, stability, and flexibility. Herein we report Langmuir–Blodgett (LB) spin-coated-film-based bipolar devices material 1,4-bis(di(1H-indol-3-yl)methyl)benzene (Indole1). The pressure–area per isotherm (π–A), Brewster angle microscopy (BAM), atomic force (AFM), scanning electron (SEM) were used formulate an idea about the...

Here, redox active aliphatic luminescent polymers (ALPs) are synthesized via polymerization of N,N-dimethyl-2-propenamide (DMPA) and 2-methyl-2-propenoic acid (MPA). The structures properties the optimum ALP3, ALP3-aggregate Cu(I)-ALP3, ratiometric pH sensing, activity, aggregation enhanced emission (AEE), Stokes shift, oxygen-donor selective coordination-reduction Cu(II) to Cu(I) explored spectroscopic, microscopic, density functional theory-reduced gradient (DFT-RDG), fluorescence...

This paper presents for the first time a base and metal free procedure Knoevenagel condensation reaction in neutral medium comprises water-SDS-imidazolium ionic liquid composite system. products from different aromatic aldehydes active methylene compounds such as malononitrile, ethyl cyanoacetate or cyano acetic acid provides good to excellent yields all cases examined at 80 °C. The developed protocol has several advantages chromatography organic volatile solvent protocol, short...

Nitrogen heterocycles with contiguous quaternary and tertiary stereocenters have been prepared in high enantiomeric purity by intramolecular conjugate addition of enolates generated from α-amino acid derivatives via memory chirality.

Abstract From a synthetic point of view, the Lewis acid1 catalyzed homologation cyclic ketones with diazo-acetic ester (1·2) is very useful. It provides direct method for constructing less accessible ring systems from readily available ones.2-8 Moreover, simultaneously formed β-keto functionality highly suitable further manipulation.9 Although reaction has been established more than decade, little documented concerning migratory apptitudes unsymmetrical except case cyclobutanones.6 Such information

An environmentally benign and highly substrate-protic ionic liquid controlled synthesis of 1,2-disubstituted 2-substituted benzimidazoles with outstanding selectivity is demonstrated through grinding a mixture OPD, aldehydes catalyst.

Abstract Excited‐state intramolecular proton transfer (ESIPT)‐associated dual‐state emissive aliphatic dual‐light emitting conducting polymers (DLECPs) having oxidation‐reduction capacities are prepared polymerizing 2‐acrylamido‐2‐methylpropane‐1‐sulfonic acid, methacrylic and 2‐methyl‐3‐( N ‐(2‐methyl‐1‐sulfopropan‐2‐yl)acrylamido)propanoic acid monomers. Of as‐synthesized DLECPs, nuclear magnetic resonance (NMR) Fourier transform infrared (FTIR) spectroscopies, fluorescent enhancements ( I...

In this communication, we report the design and synthesis as well supramolecular assembly behavior of a 2,4,5-triaryl imidazole derivative (compound 1) at air–water interface in thin films using Langmuir–Blodgett (LB) technique. The main idea for such chemical structure is that long alkyl chain N–H core may help to form architecture through hydrophobic–hydrophobic interaction hydrogen bonding, respectively. Accordingly, interfacial morphology 1 were studied series characterization methods...

Complementary resistive switching (CRS) devices are more advantageous compared to bipolar (BRS) for memory applications as they can minimize the sneak path problem observed in case of BRS having a crossbar array structure. Here, we report CRS behavior 1,4-bis(di(1H-indol-3-yl)methyl)benzene (Indole1) molecules. Our earlier study revealed that Au/Indole1/Indium tin oxide (ITO) showed under ambient conditions. However, present investigations when device is exposed 353 K or higher temperatures,...

An ionic liquid catalyzed dual C–N/C–C coupled cyclization under solvent-free green conditions to DHPMs and their innovative new organic materials by LB film study are demonstrated.

Techniques to pattern cells on biocompatible hydrogels allow for the creation of highly controlled cell microenvironments within materials that mimic physicochemical properties native tissues. Such technology has potential further enhance our knowledge biology and play a role in development novel tissue engineering devices. Light is an ideal stimulus catalyze formation since it can be spatially as well temporally. Herein, we have developed enhanced hydrogel patterning strategy. It based...

Abstract Photocaged RGDS is a cell nonadhesive tetrapeptide that can be activated with light to become cell‐adhesive. Such molecules find useful applications in controlling adhesion for biological study, drug development, and forming dynamic, adhesion‐controlled biomaterials. Herein, we prepared peptide photocaged either on the Arg‐Gly backbone amide nitrogen atom (R[−]GDS) or Asp side chain carboxyl (RG[D]S). A critical comparison of peptides' chemical physiological properties relevant was...

Abstract: In recent years, histone deacetylases (HDACs) have been considered one of the promising targets for cancer chemotherapy. present study, a six-featured pharmacophore model with two hydrogen bond acceptors (AA), donors (DD), and aromatic rings (RR) was developed. A predictive three-dimensional quantitative structure–activity relationship generated using models obtained. The has an excellent correlation coefficient good ability, as shown by significant statistical parameters both...

A metal-free, simultaneous triple C-C coupling cyclization reaction between phenacyl bromides and indoles is discovered in a highly regioselective fashion to furnish 3,5-diarylcarbazoles. DMAP utilized as the only reagent for unusual rapid all new carbazole compounds through installation of great diversity substituents. plausible radical mechanism predicted by conducting various control experiments, competitive reactions, furoindole formation, ESI-MS analyses ongoing reaction.

Chiral 1,2-dihydropyridines were prepared by Dieckmann condensation of -amino acid derivatives.The dihydropyridines converted to 2,3,4-trisubstituted pyridines.R CO 2 Et N (CH ) n Boc Br R KHMDS = ~ 5, up 98% ee CH OMe Me 93% i ii) MeI

Abstract Sustainable and highly efficient one‐pot multicomponent syntheses of functionalized imidazole derivatives were described using benzil, aldehydes, ammonium acetate/or amines in the presence Amberlite IR 120H + . The products obtained short period time with high yields through chromatography‐free procedure. catalyst could be recycled due to its insolubility most solvents reused without any noticeable decrease catalytic activity. novel strategy was exploited for synthesis a designed...

Abstract A sustainable route for the Henry reaction of isatins with nitromethane or nitroethane to afford 3‐hydroxy‐3‐(nitroalkyl)indolin‐2‐ones was developed by catalysis 1‐butyl‐3‐methyl imidazolium hydroxide (BMIm[OH]) ionic liquid in water‐SDS system. Incorporation SDS medium enhances rate suppressing solubility issues different substrates particularly N ‐alkylated isatins. This method provides high yield condensation product a shorter time under very mild condition and multi‐gram scale...

In this study, we designed and synthesised a series of coumarin derivatives appended with long alkoxy chain on the seventh position coumarin-3-carboxylate/carboxylic acid core to make thin film materials. Synthesised compounds were characterized by their UV fluorescence spectra in solutions as well films prepared both LB spin-coated methods. The surface morphology electrical behaviour judged AFM, SEM I-V characteristic mapping respectively. Isotherm, UV-Vis absorption spectroscopic...