A5042091415- Monoclonal and Polyclonal Antibodies Research
- Acute Myeloid Leukemia Research
- HER2/EGFR in Cancer Research
- Epigenetics and DNA Methylation
- Nanofabrication and Lithography Techniques
- Streptococcal Infections and Treatments
- Hemoglobinopathies and Related Disorders
- Peptidase Inhibition and Analysis
- Heart Failure Treatment and Management
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- interferon and immune responses
- Erythrocyte Function and Pathophysiology
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- RNA Interference and Gene Delivery
- Plant Molecular Biology Research
- Cancer Research and Treatments
- Genomics and Phylogenetic Studies
- Kruppel-like factors research
- Venomous Animal Envenomation and Studies
- Salmonella and Campylobacter epidemiology
- Plant Reproductive Biology
- Cell Adhesion Molecules Research
Medical University of Vienna
2019-2020
BOKU University
2019
Utrecht University
2013-2016
Genmab (Netherlands)
2015
University Medical Center Utrecht
2013
Charité - Universitätsmedizin Berlin
2006-2008
MSB Medical School Berlin
2008
Upon contact with human plasma, bacteria are rapidly recognized by the complement system that labels their surface for uptake and clearance phagocytic cells. Staphylococcus aureus secretes 16 kD Extracellular fibrinogen binding protein (Efb) binds two different plasma proteins using separate domains: Efb N-terminus to fibrinogen, while C-terminus C3. In this study, we show blocks phagocytosis of S. neutrophils. vitro, demonstrate in whole blood. Using a mouse peritonitis model effectively...
Abstract Antibody–drug conjugates (ADC) are emerging as powerful cancer treatments that combine antibody-mediated tumor targeting with the potent cytotoxic activity of toxins. We recently reported development a novel ADC delivers payload monomethyl auristatin E (MMAE) to cells expressing tissue factor (TF). By carefully selecting TF-specific antibody interferes TF:FVIIa-dependent intracellular signaling, but not procoagulant TF, an was developed (TF-011-MMAE/HuMax-TF-ADC) efficiently kills...
The transmembrane zink-metalloendopeptidase neprilysin (NEP) is implicated in cardiovascular disease but also tumor biology. aim of the study was to investigate relationship circulating NEP (cNEP) levels with established biomarkers and its effect on overall survival an unselected cohort treatment-naïve cancer patients. 555 consecutive patients prior anticancer therapy were enrolled prospectively. determined alongside routine laboratory parameters, cardiac biomarkers, i.e. NT-proBNP, hsTnT,...
Flagella are nanofibers that drive bacterial movement. The filaments generally composed of thousands tightly packed flagellin subunits with a terminal cap protein, named FliD. Here, we report the FliD protein pathogen Campylobacter jejuni binds to host cells. Live-cell imaging and confocal microscopy showed initial contact bacteria epithelial cells via flagella tip. Recombinant bound surface intestinal in dose-dependent fashion. Search for binding site on cell using defined glycosylation...
Abstract Aim GDF‐15 is an established cardiovascular risk marker but equally implicated in tumour biology. Elevated levels of have indeed been observed distinct entities. This study aimed to explore the relation other cardiac biomarkers and general association on prognosis unselected cohort treatment‐naïve cancer patients. Methods We prospectively enrolled 555 consecutive patients at time diagnosis malignant disease prior receiving anticancer therapy. Plasma concentrations were determined...
Background Neprilysin is a transmembrane endopeptidase involved in the breakdown of variety vasoactive peptides and serves as therapeutic target heart failure with reduced ejection fraction (HFrEF). This study aimed to investigate relationship circulating neprilysin neurohumoral activation impact plasma activity on prognosis HFrEF. Methods Results A total 369 chronic HFrEF patients were enrolled prospectively. Plasma concentration determined by specific ELISA fluorometric method. The...
While secondary mitral regurgitation (sMR) is associated with adverse outcome in heart failure reduced ejection fraction (HFrEF), key pathophysiologic mechanisms remain poorly understood and might be elucidated by microRNAs (miRNA/miR), that were recently related to cardiac remodelling. This study sought assess (i) the differences of miRNA profiles patients severe sMR compared matched disease controls, (ii) correlation between circulating miRNAs surrogates severity as well (iii) prognostic...
SUMMARY The timing of plant developmental transitions is decisive for reproductive success and thus tightly regulated. transition from juvenile to adult vegetative later the phase controlled by an endogenous pathway regulated miR156, targeting SQUAMOSA PROMOTER BINDING PROTEIN (SBP/SPL) family transcription factors. SPLs regulate a number processes, such as trichome formation, leaf shape floral transition. Such complex regulatory pathways often involve post-translational modifications...
<p>Supplementary Method S1: Quantitative determination of cell surface antigens. Supplementary S2: Synthesis Duostatin-3. Table Apparent antibody affinities. Figure Distribution HER2, EGFR and TF in unstimulated HCC1954 cells. Endosomal lysosomal colocalisation TF, HER2 tumor cells after treatment with target-specific antibodies. S3: Flow cytometry analysis SK-OV-3 ADC-treatment.</p>
<p>Supplementary Method S1: Quantitative determination of cell surface antigens. Supplementary S2: Synthesis Duostatin-3. Table Apparent antibody affinities. Figure Distribution HER2, EGFR and TF in unstimulated HCC1954 cells. Endosomal lysosomal colocalisation TF, HER2 tumor cells after treatment with target-specific antibodies. S3: Flow cytometry analysis SK-OV-3 ADC-treatment.</p>
<div>Abstract<p>Antibody–drug conjugates (ADC) are emerging as powerful cancer treatments that combine antibody-mediated tumor targeting with the potent cytotoxic activity of toxins. We recently reported development a novel ADC delivers payload monomethyl auristatin E (MMAE) to cells expressing tissue factor (TF). By carefully selecting TF-specific antibody interferes TF:FVIIa-dependent intracellular signaling, but not procoagulant TF, an was developed (TF-011-MMAE/HuMax-TF-ADC)...
<div>Abstract<p>Antibody–drug conjugates (ADC) are emerging as powerful cancer treatments that combine antibody-mediated tumor targeting with the potent cytotoxic activity of toxins. We recently reported development a novel ADC delivers payload monomethyl auristatin E (MMAE) to cells expressing tissue factor (TF). By carefully selecting TF-specific antibody interferes TF:FVIIa-dependent intracellular signaling, but not procoagulant TF, an was developed (TF-011-MMAE/HuMax-TF-ADC)...